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2000
Volume 18, Issue 10
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Metallo-β-lactamases (MBLs) are a family of Zn(II)-dependent enzymes that can hydrolyze almost all β-lactam antibiotics. Horizontal transfer of the genes encoding MBLs among Gram-negative bacteria pathogens has led to the emergence of extensively drug-resistant pathogens, which now represent a major threat to human health. As there is not to date yet a clinically available MBL inhibitor, the discovery of new MBL inhibitors has great urgency. This review highlights the recent developments in the discovery of small-molecule MBL inhibitors.

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/content/journals/ctmc/10.2174/1568026618666180518101028
2018-04-01
2025-07-15
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