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2000
Volume 17, Issue 21
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Addiction is a chronic, relapsing disease of the brain that includes drug-induced compulsive seeking behavior and consumption of drugs. Dopamine (DA) is considered to be critical in drug addiction due to reward mechanisms in the midbrain. In this article, we review the major animal models in addictive drug experiments in vivo and in vitro. We discuss the relevance of the structure and pharmacological function of DA receptors. To improve the understanding of the role of DA receptors in reward pathways, specific brain regions, including the Ventral tegmental area, Nucleus accumbens, Prefrontal cortex, and Habenula, are highlighted. These factors contribute to the development of novel therapeutic targets that act at DA receptors. In addiction, the development of neuroimaging method will increase our understanding of the mechanisms underlying drug addiction.

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/content/journals/ctmc/10.2174/1568026617666170504100642
2017-08-01
2025-07-03
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/content/journals/ctmc/10.2174/1568026617666170504100642
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  • Article Type:
    Research Article
Keyword(s): Addiction; Brain regions; Dopamine; Dopamine receptors; PA receptor; Perforental cortex
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