Skip to content
2000
Volume 16, Issue 28
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Tuberculosis (TB) has been declared as a health emergency due to emergence of resistant strains of M. tuberculosis, multidrug resistant (MDR), extensively drug resistant (XDR) TB strains and totally drug resistant tuberculosis (TDR-TB) reported recently in some parts of the world. Therefore, the current situation necessitates developing new antitubercular agents acting on novel targets for effectively controlling TB. Thymidine Monophosphate Kinase (TMPKmt) enzyme is one such target, which is being explored. This review focuses on Structure Activity Relationship studies (SARs) and computational studies of various nucleotide and nucleoside derivatives of pyrimidine analogs reported as TMPKmt inhibitors.

Loading

Article metrics loading...

/content/journals/ctmc/10.2174/1568026616666160506130914
2016-11-01
2025-07-09
Loading full text...

Full text loading...

/content/journals/ctmc/10.2174/1568026616666160506130914
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test