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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors
- Source: Current Topics in Medicinal Chemistry, Volume 16, Issue 13, May 2016, p. 1413 - 1426
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- 01 May 2016
Abstract
The PI3K signaling cascade is the key moderator of cell proliferation, survival, motility, and apoptosis. Class I PI3K proteins are well characterized and linked to thrombosis (PI3Kβ), rheumatoid arthritis (PI3Kδ), and cancer (PI3Kα). In this review, we explore the latest progress in the design and development of selective Class I PI3K inhibitors from the perspective of drug design and structure activity relationships.
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