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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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Molecular Modeling Based Synthesis and Evaluation of In vitro Anticancer Activity of Indolyl Chalcones
- Source: Current Topics in Medicinal Chemistry, Volume 15, Issue 11, Jun 2015, p. 1003 - 1012
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- 01 Jun 2015
Abstract
A series of twenty one chalcone derivatives having indole moiety were synthesized and were evaluated against four human cancer cell lines. Indolyl chalcones 1a, 1b, 1d, 1f-1j, 2c, 2e, 2i showed good anticancer activity. Chalcones 1b and 1d were the most active and selective anticancer agents with IC50 values <1μg/ml and 1.51μg/ml, against WRL-68 cell line, respectively. Molecular mechanism was explored through in silico docking & ADMET studies.
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