Skip to content
2000
Volume 14, Issue 23
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Nanodiscs are disc-like structures formed by two copies of a membrane scaffold protein, engineered from apolipoprotein A-I, surrounding a phospholipid mixture that can incorporate membrane proteins preserving their natural properties. They behave as soluble entities allowing the use of high-resolution structural techniques to determine the structural organization of the embedded membrane protein, and the use of solution biochemical-biophysical tools to measure its activity, assembly and interactions with other proteins in membranelike environments. In addition, nanodiscs are biocompatible which makes them an attractive technology to be used in therapy, drug discovery, and other biotechnological applications.

Loading

Article metrics loading...

/content/journals/ctmc/10.2174/1568026614666141215142951
2014-12-01
2025-03-16
Loading full text...

Full text loading...

/content/journals/ctmc/10.2174/1568026614666141215142951
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test