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2000
Volume 14, Issue 22
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

The chemical versatility of the indole nucleus still inspires the pharmaceutical research to develop innovative suitable indole based drugs. The present work is an overview of the use and application of indole molecule based derivatives, as possible treatment in the main Oxidative Stress related diseases, such as cardiovascular, neurological, and cancer. The indole nucleus is a particular class of reducers, very efficient when bearing aliphatic substitutions in position 3, like that found in tryptophan (Trp). The principal chemical modifications carried out on the indole nucleus, were focused to obtain orally active drugs for a simpler delivery to the patients.

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/content/journals/ctmc/10.2174/1568026614666141203142926
2014-11-01
2025-03-16
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/content/journals/ctmc/10.2174/1568026614666141203142926
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  • Article Type:
    Research Article
Keyword(s): Alzheimer; Antioxidants; Cancer; Cardiovascular diseases; Enzymes; Reactive oxygen species
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