Skip to content
2000
Volume 13, Issue 16
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

We herein report the synthesis of 3β-substituted amides of 17a-aza-D-homo-4-androsten-17-one (11a-11r) from commercially available Diosgenin as the starting material. The structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectrometry. All the synthesized analogues were tested for their 5α- reductase inhibitory and antimicrobial activity, some of them exhibit moderate to potent activity comparable to the reference drugs. Among the synthesized derivatives the analogue (11r) 3β-(indonlylbutanamido)-17a-aza-D-homo-4- androsten-17-one was found to be active against both 5-reductase enzyme and microbial strains, whereas the analogue (11i) 3β-(3,4-dimethoxy-benzamido)-17a-aza-D-homo-4-androsten-17-one was found to be the least active. The detailed 5-reductase inhibitors and antimicrobial activities of the synthesized compounds were reported.

Loading

Article metrics loading...

/content/journals/ctmc/10.2174/15680266113139990131
2013-08-01
2024-12-23
Loading full text...

Full text loading...

/content/journals/ctmc/10.2174/15680266113139990131
Loading

  • Article Type:
    Research Article
Keyword(s): 5α-Reductase; Antibacterial; Antifungal; Ciprofloxacin; Dutasteride; Voriconazole
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test