Myocardial Structure and Matrix Metalloproteinases

C. Aggeli; P. Pietri; I. Felekos; L. Rautopoulos; K. Toutouzas; E. Tsiamis; C. Stefanadis

doi:10.2174/1568026611208011113

ISSN: 1568-0266
E-ISSN: 1873-4294

Myocardial Structure and Matrix Metalloproteinases
Authors: C. Aggeli¹, P. Pietri², I. Felekos³, L. Rautopoulos⁴, K. Toutouzas⁵, E. Tsiamis⁶ and C. Stefanadis⁷
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¹ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ² 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ³ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ⁴ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ⁵ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ⁶ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece. ⁷ 14 Argirokastrou St, Vrilisia, P.O 15235, Athens, Greece.
Source: Current Topics in Medicinal Chemistry, Volume 12, Issue 10, May 2012, p. 1113 - 1131
DOI: https://doi.org/10.2174/1568026611208011113
- Available online: 01 May 2012

Abstract

Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.

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2012-05-01

2025-05-12

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Article Type: Research Article

Keyword(s): cardiac remodeling; cardiomyopathy; cardiovascular diseases; cell surface proteins; clinical and therapeutic implications; extracellular matrix proteins; fibrillar collagens; left ventricular (LV); Metaloproteinases; myocardial remodeling; myocardial structure; numerous studies; prognostic role of MMPs

Myocardial Structure and Matrix Metalloproteinases

Abstract

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