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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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Synthesis of Salinosporamide A and Its Analogs as 20S Proteasome Inhibitors and SAR Summarization
- Source: Current Topics in Medicinal Chemistry, Volume 11, Issue 23, Dec 2011, p. 2906 - 2922
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- 01 Dec 2011
Abstract
Salinosporamide A (4), a secondary metabolite of the marine actinomycete Salinispora tropica, is a potent inhibitor of 20S proteasome that is currently in clinical trials for the treatment of cancers. Herein, we described various synthetic strategies of 4 and summarized the SAR of 4 and its analogs.
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