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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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Bradykinin B1 Receptor Antagonists as Novel Analgesics: A Retrospective of Selected Medicinal Chemistry Developments
- Source: Current Topics in Medicinal Chemistry, Volume 8, Issue 16, Nov 2008, p. 1420 - 1430
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- 01 Nov 2008
Abstract
Bradykinin B1 receptor antagonists embody a potentially novel approach for the treatment of chronic pain and inflammation. The identification of non-peptide B1 antagonists has been a notable advance in the kinin field that will allow evaluation of their therapeutic potential in the clinical realm. The current review is a high level summary of our contributions to the area that culminated in the discovery of a clinical candidate.
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