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2000
Volume 8, Issue 9
  • ISSN: 1568-0266
  • E-ISSN: 1873-4294

Abstract

Selective Estrogen Receptor Modulators (SERMs) have been the subject of extensive medicinal chemistry efforts at several pharmaceutical companies, including Merck. The Merck effort produced a wide variety of SERMs including ER-?? selective antagonists and ER-?? agonists in addition to balanced (non-selective) analogs. This article will provide a broad overview of the Merck SERM medicinal chemistry effort as published in the literature through early 2008.

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/content/journals/ctmc/10.2174/156802608784535066
2008-06-01
2025-06-14
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