Photosensitive Precursors to Nitric Oxide

Christopher M. Pavlos; Hua Xu; John P. Toscano

doi:10.2174/1568026054679326

ISSN: 1568-0266
E-ISSN: 1873-4294

Photosensitive Precursors to Nitric Oxide
Authors: Christopher M. Pavlos¹, Hua Xu² and John P. Toscano³
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Affiliations: ¹ Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA; ² Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA; ³ Department of Chemistry, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA;
Source: Current Topics in Medicinal Chemistry, Volume 5, Issue 7, Jul 2005, p. 637 - 647
DOI: https://doi.org/10.2174/1568026054679326
- Available online: 01 Jul 2005

Abstract

The photochemistry and use of recently developed photosensitive precursors to nitric oxide (NO) are reviewed. As "caged NO" donors these precursors are able to deliver NO in a spatially and temporally controllable manner. These properties have made such precursors useful in applications in biology and medicine, especially in elucidating neurophysiological roles of NO and in new cancer therapies.

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2005-07-01

2025-01-10

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Article Type: Review Article

Keyword(s): diazeniumdiolate; meta substituents; nucleophiles; photodynamic therapy; photolysis; photorelease

Photosensitive Precursors to Nitric Oxide

Abstract

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