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- ISSN: 1568-0266
- E-ISSN: 1873-4294
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The Application of X-ray, NMR, and Molecular Modeling in the Design of MMP Inhibitors
- Source: Current Topics in Medicinal Chemistry, Volume 4, Issue 12, Aug 2004, p. 1311 - 1327
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- 01 Aug 2004
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Abstract
The following review discusses the successful application of X-ray, NMR, and molecular modeling in the design of potent and selective inhibitors of matrix metalloproteinases (MMPs) and TNFα-converting enzyme (TACE) from Wyeth. The importance of protein and ligand mobility as it impacts structure-based design is also discussed. The MMPs are an active target for a variety of diseases, including cancer and arthritis.
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