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Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery
- Source: Current Topics in Medicinal Chemistry, Volume 2, Issue 3, Mar 2002, p. 229 - 246
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- 01 Mar 2002
Abstract
Increasing insight into the genetics and molecular biology of cancer has resulted in the identification of an increasing number of potential molecular targets for anti-cancer drug discovery and development. These targets can be approached through exploitation of emerging structural biology,”rational“ drug design, screening of chemical libraries, or a combination of these methods. In this article we discuss the application of high-throughput screening to anti-cancer drug discovery, with special reference to approaches used at the U.S. National Cancer Institute.
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