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2000
Volume 19, Issue 4
  • ISSN: 1574-888X
  • E-ISSN: 2212-3946

Abstract

Introduction: To evaluate the biological interaction between dental stem cells (DSCs) and different growth factors in the field of regenerative endodontics.Methods: A systematic search was conducted in the electronic databases up to October 2021. This study followed the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. studies evaluating the biological interactions of DSCs and growth factors were included. The meta-analysis was performed according to the type of growth factor. The outcomes were cell viability/ proliferation and mineralization. Standardized mean differences (SMDs) were estimated using the random-effect maximum-likelihood method ( < .05). Additional analysis was performed to find any potential source of heterogeneity.Results: Twenty articles were included in the systematic review; meta-analysis was performed for fibroblast growth factor-2 (FGF-2) and Transforming growth factor- (TGF-β1) (n = 5). Results showed that use of FGF-2 significantly increased cell proliferation on day 1-(SMD = 3.56, = 0.00), 3-(SMD = 9.04, = 0.00), 5-(SMD = 8.37, = 0.01), and 7 (SMD=8.51, =0.00) than the control group. TGF- increased alkaline phosphatase (ALP) activity more than control only on day 3 (SMD = 3.68, = 0.02). TGF-β1 had no significant effect on cell proliferation on days 1 and 3 ( > 0.05) and on ALP activity on days 5 and 7 ( > 0.05). Meta-regression analysis showed that different covariates (., cell type, passage number, and growth factors' concentration) could significantly influence the effect sizes at different follow- ups ( < 0.05).Conclusion: Specific growth factors might enhance the proliferation and mineralization of DSCs; however, the obtained evidence was weak. Due to the high heterogeneity among the included studies, other growth factors' inhibitory/stimulatory effects on DSCs could not be evaluated.

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/content/journals/cscr/10.2174/1574888X17666220628125048
2024-05-01
2025-05-24
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