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- ISSN: 1574-888X
- E-ISSN: 2212-3946
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Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress
- Source: Current Stem Cell Research & Therapy, Volume 16, Issue 7, Oct 2021, p. 792 - 800
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- 01 Oct 2021
Abstract
Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.
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