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image of Immunomodulatory Roles of Mesenchymal Stem Cell-derived Extracellular Vesicles: A Promising Therapeutic Approach for Autoimmune Diseases

Abstract

Autoimmune diseases pose a significant challenge due to their complex pathogenesis and rising prevalence. Traditional therapies are often limited by systemic side effects, immunosuppression, and lack of long-term efficacy. Mesenchymal stem cells (MSCs) have demonstrated immunomodulatory properties, primarily through the secretion of extracellular vesicles (EVs), which are now recognized as potent mediators of immune regulation. MSC-derived EVs carry bioactive molecules such as microRNAs, proteins, and lipids that influence key immune pathways, making them a promising therapeutic avenue for autoimmune diseases. This review critically examines the immunomodulatory mechanisms of MSC-derived EVs, focusing on their role in regulating T cells, B cells, and macrophages, which are central to autoimmune pathology. We explore recent preclinical and clinical studies that highlight the ability of MSC-derived EVs to reduce inflammation, promote immune tolerance, and restore tissue homeostasis in autoimmune settings. Furthermore, we discuss the advantages of EV-based therapy over MSC-based therapies, including improved safety profiles, lower immunogenicity, and scalability for clinical application. By evaluating the current landscape of MSC-derived EV research, we identify key gaps and propose innovative strategies to optimize EV-based therapies for autoimmune diseases. These strategies include engineering EVs to enhance their specificity and therapeutic efficacy, as well as integrating them with biomaterials for targeted delivery. Our review aims to provide a forward-looking perspective on the potential of MSC-derived EVs as a novel therapeutic approach, moving beyond traditional cell-based therapies to offer more precise and personalized treatment options for autoimmune diseases.

© 2024 Bentham Science Publishers
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2024-12-27
2025-01-22

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References

  1. Rosenblum M.D. Remedios K.A. Abbas A.K. Mechanisms of human autoimmunity. J. Clin. Invest. 2015 125 6 2228 2233 10.1172/JCI78088 25893595
    [Google Scholar]
  2. Wen J. Zhang J. Zhang H. Zhang N. Lei R. Deng Y. Cheng Q. Li H. Luo P. Large-scale genome-wide association studies reveal the genetic causal etiology between air pollutants and autoimmune diseases. J. Transl. Med. 2024 22 1 392 10.1186/s12967‑024‑04928‑y 38685026
    [Google Scholar]
  3. Smith D. A. Germolec D. R. "Introduction to immunology and autoimmunity," (in eng) Environ Health Perspect 107 Suppl 5 661 665 10.1289/ehp.99107s5661
    [Google Scholar]
  4. Haque N. Ramasamy T.S. Kasim N.H.A. Mechanisms of mesenchymal stem cells for autoimmune disease treatment. Stem Cell Transplant. Autoimmun. Inflamm. 2019 27 44 10.1007/978‑3‑030‑23421‑8_2
    [Google Scholar]
  5. Angum F. Khan T. Kaler J. Siddiqui L. Hussain A. The prevalence of autoimmune disorders in women: a narrative review. Cureus 2020 12 5 e8094 e8094 10.7759/cureus.8094 32542149
    [Google Scholar]
  6. Hussain M.S. Chaturvedi V. The present condition of sickle cell disease: an overview of stem cell transplantation as a cure. Pharm. Fronts 2023 5 2 e57 e63 10.1055/s‑0043‑1768918
    [Google Scholar]
  7. Rad F. Ghorbani M. Mohammadi Roushandeh A. Habibi Roudkenar M. Mesenchymal stem cell-based therapy for autoimmune diseases: emerging roles of extracellular vesicles. Mol. Biol. Rep. 2019 46 1 1533 1549 10.1007/s11033‑019‑04588‑y 30623280
    [Google Scholar]
  8. Bahl G. Pathak Y. Hussain M.S. Gupta Y. Saraswat N. Navigating Sheehan syndrome’s silent onset: A case report. J. Clin. Transl. Endocrinol. Case Rep. 2024 32 100168 10.1016/j.jecr.2024.100168
    [Google Scholar]
  9. Tyndall A. Successes and failures of stem cell transplantation in autoimmune diseases. Hematology (Am. Soc. Hematol. Educ. Program) 2011 2011 1 280 284 10.1182/asheducation‑2011.1.280 22160046
    [Google Scholar]
  10. Baharlooi H. Azimi M. Salehi Z. Izad M. Mesenchymal stem cell-derived exosomes: a promising therapeutic ace card to address autoimmune diseases. Int. J. Stem Cells 2020 13 1 13 23 10.15283/ijsc19108 31887849
    [Google Scholar]
  11. Gupta G. Hussain M.S. Thapa R. Dahiya R. Mahapatra D.K. Bhat A.A. Singla N. Subramaniyan V. Rawat S. Jakhmola V. S R. Dua K. Hope on the horizon: Wharton’s jelly mesenchymal stem cells in the fight against COVID-19. Regen. Med. 2023 18 9 675 678 10.2217/rme‑2023‑0077 37554111
    [Google Scholar]
  12. Zhuo Y. Li W.S. Lu W. Li X. Ge L.T. Huang Y. Gao Q.T. Deng Y.J. Jiang X.C. Lan Z.W. Deng Q. Chen Y.H. Xiao Y. Lu S. Jiang F. Liu Z. Hu L. Liu Y. Ding Y. He Z.W. Tan D.A. Duan D. Lu M. TGF-β1 mediates hypoxia-preconditioned olfactory mucosa mesenchymal stem cells improved neural functional recovery in Parkinson’s disease models and patients. Mil. Med. Res. 2024 11 1 48 10.1186/s40779‑024‑00550‑7 39034405
    [Google Scholar]
  13. Luque-Campos N. Mesenchymal stem cells improve rheumatoid arthritis progression by controlling memory T cell response. Front. Immunol. Rev. 2019 10 798 10.3389/fimmu.2019.00798
    [Google Scholar]
  14. Cipriani P. Carubbi F. Liakouli V. Marrelli A. Perricone C. Perricone R. Alesse E. Giacomelli R. Stem cells in autoimmune diseases: Implications for pathogenesis and future trends in therapy. Autoimmun. Rev. 2013 12 7 709 716 10.1016/j.autrev.2012.10.004 23183379
    [Google Scholar]
  15. Tian S. Chen X. Wu W. Lin H. Qing X. Liu S. Wang B. Xiao Y. Shao Z. Peng Y. Nucleus pulposus cells regulate macrophages in degenerated intervertebral discs via the integrated stress response-mediated CCL2/7-CCR2 signaling pathway. Exp. Mol. Med. 2024 56 2 408 421 10.1038/s12276‑024‑01168‑4 38316963
    [Google Scholar]
  16. Lan Z. Tan F. He J. Liu J. Lu M. Hu Z. Zhuo Y. Liu J. Tang X. Jiang Z. Lian A. Chen Y. Huang Y. Curcumin-primed olfactory mucosa-derived mesenchymal stem cells mitigate cerebral ischemia/reperfusion injury-induced neuronal PANoptosis by modulating microglial polarization. Phytomedicine 2024 129 155635 10.1016/j.phymed.2024.155635 38701541
    [Google Scholar]
  17. Seo Y. Kim H-S. Hong I-S. Stem cell-derived extracellular vesicles as immunomodulatory therapeutics. Stem Cells International 2019 5126156 10.1155/2019/5126156
    [Google Scholar]
  18. Sadique Hussain M. Exosomal ncRNAs in liquid biopsies for lung cancer. Int. J. Clini. Chem. 565 119983 2024 10.1016/j.cca.2024.119983
    [Google Scholar]
  19. Cooper G.S. Bynum M.L.K. Somers E.C. Recent insights in the epidemiology of autoimmune diseases: Improved prevalence estimates and understanding of clustering of diseases. J. Autoimmun. 2009 33 3-4 197 207 10.1016/j.jaut.2009.09.008 19819109
    [Google Scholar]
  20. Yamamoto K. Introduction: autoimmunity special issue. Int. Immunol. 2016 28 4 153 154 10.1093/intimm/dxw010 27034456
    [Google Scholar]
  21. Okada H. Kuhn C. Feillet H. Bach J-F. The ‘hygiene hypothesis’ for autoimmune and allergic diseases: an update. Clin. Exp. Immunol. 2010 160 1 1 9 10.1111/j.1365‑2249.2010.04139.x 20415844
    [Google Scholar]
  22. Bolon B. Cellular and molecular mechanisms of autoimmune disease. Toxicol. Pathol. 2012 40 2 216 229 10.1177/0192623311428481 22105648
    [Google Scholar]
  23. Yang S.H. Gao C. Li L. Chang C. Leung P.S.C. Gershwin M.E. Lian Z.X. The molecular basis of immune regulation in autoimmunity. Clin. Sci. 2018 132 1 43 67 10.1042/CS20171154 29305419
    [Google Scholar]
  24. Chandrashekara S. The treatment strategies of autoimmune disease may need a different approach from conventional protocol: A review. Indian J. Pharmacol. 2012 44 6 665 671 10.4103/0253‑7613.103235 23248391
    [Google Scholar]
  25. Blázquez-Prunera A. Almeida C. Barbosa M. Human bone marrow mesenchymal stem/stromal cells preserve their immunomodulatory and chemotactic properties when expanded in a human plasma derived xeno-free medium Stem cells Int 2017 2017 1 10.1155/2017/2185351
    [Google Scholar]
  26. François M. Romieu-Mourez R. Li M. Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol. Ther. 2012 20 1 187 195 10.1038/mt.2011.189 21934657
    [Google Scholar]
  27. Engela A.U. Hoogduijn M.J. Boer K. Litjens N.H.R. Betjes M.G.H. Weimar W. Baan C.C. Human adipose-tissue derived mesenchymal stem cells induce functional de-novo regulatory T cells with methylated FOXP3 gene DNA. Clin. Exp. Immunol. 2013 173 2 343 354 10.1111/cei.12120 23607314
    [Google Scholar]
  28. Gieseke F. Kruchen A. Tzaribachev N. Bentzien F. Dominici M. Müller I. Proinflammatory stimuli induce galectin‐9 in human mesenchymal stromal cells to suppress T ‐cell proliferation. Eur. J. Immunol. 2013 43 10 2741 2749 10.1002/eji.201343335 23817958
    [Google Scholar]
  29. Hinden L. Shainer R. Almogi-Hazan O. Or R. Ex vivo induced regulatory human/murine mesenchymal stem cells as immune modulators. Stem Cells 2015 33 7 2256 2267 10.1002/stem.2026 25850816
    [Google Scholar]
  30. Huang F. Chen M. Chen W. Gu J. Yuan J. Xue Y. Dang J. Su W. Wang J. Zadeh H.H. He X. Rong L. Olsen N. Zheng S.G. Human gingiva-derived mesenchymal stem cells inhibit xeno-graft-versus-host disease via CD39–CD73–adenosine and IDO signals. Front. Immunol. 2017 8 68 10.3389/fimmu.2017.00068 28210258
    [Google Scholar]
  31. Bai L. Lennon D.P. Eaton V. Maier K. Caplan A.I. Miller S.D. Miller R.H. Human bone marrow‐derived mesenchymal stem cells induce Th2‐polarized immune response and promote endogenous repair in animal models of multiple sclerosis. Glia 2009 57 11 1192 1203 10.1002/glia.20841 19191336
    [Google Scholar]
  32. Uccelli A. Laroni A. Brundin L. Clanet M. Fernandez O. Nabavi S.M. Muraro P.A. Oliveri R.S. Radue E.W. Sellner J. Soelberg Sorensen P. Sormani M.P. Wuerfel J.T. Battaglia M.A. Freedman M.S. MESEMS study group Mesenchymal Stem cells for Multiple Sclerosis (MESEMS): a randomized, double blind, cross-over phase I/II clinical trial with autologous mesenchymal stem cells for the therapy of multiple sclerosis. Trials 2019 20 1 263 10.1186/s13063‑019‑3346‑z 31072380
    [Google Scholar]
  33. Hou Z. Liu Y. Mao X.H. Wei C. Meng M. Liu Y. Zhuyun Yang Z. Zhu H. Short M. Bernard C. Xiao Z. Transplantation of umbilical cord and bone marrow-derived mesenchymal stem cells in a patient with relapsing-remitting multiple sclerosis. Cell Adhes. Migr. 2013 7 5 404 407 10.4161/cam.26941 24192520
    [Google Scholar]
  34. Yan L. Jiang B. Niu Y. Wang H. Li E. Yan Y. Sun H. Duan Y. Chang S. Chen G. Ji W. Xu R.H. Si W. Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. Cell Death Discov. 2018 4 1 89 10.1038/s41420‑018‑0091‑0 30131877
    [Google Scholar]
  35. Zafranskaya M. Nizheharodava D. Yurkevich M. Ivanchik G. Demidchik Y. Kozhukh H. Fedulov A. PGE2 contributes to in vitro MSC-mediated inhibition of non-specific and antigen-specific T cell proliferation in MS patients. Scand. J. Immunol. 2013 78 5 455 462 10.1111/sji.12102 23944654
    [Google Scholar]
  36. Zhang H. Liang J. Tang X. Wang D. Feng X. Wang F. Hua B. Wang H. Sun L. Sustained benefit from combined plasmapheresis and allogeneic mesenchymal stem cells transplantation therapy in systemic sclerosis. Arthritis Res. Ther. 2017 19 1 165 10.1186/s13075‑017‑1373‑2 28724445
    [Google Scholar]
  37. Chang J.W. Hung S.P. Wu H.H. Wu W.M. Yang A.H. Tsai H.L. Yang L.Y. Lee O.K. Therapeutic effects of umbilical cord blood-derived mesenchymal stem cell transplantation in experimental lupus nephritis. Cell Transplant. 2011 20 2 245 258 10.3727/096368910X520056 20719085
    [Google Scholar]
  38. Chen J. Umbilical cord-derived mesenchymal stem cells suppress autophagy of T cells in patients with systemic lupus erythematosus via transfer of mitochondria Stem cells Int. 2016 2016 10.1155/2016/4062789
    [Google Scholar]
  39. Choi E.W. Shin I.S. Park S.Y. Park J.H. Kim J.S. Yoon E.J. Kang S.K. Ra J.C. Hong S.H. Reversal of serologic, immunologic, and histologic dysfunction in mice with systemic lupus erythematosus by long‐term serial adipose tissue–derived mesenchymal stem cell transplantation. Arthritis Rheum. 2012 64 1 243 253 10.1002/art.33313 21904997
    [Google Scholar]
  40. Li X. Wang D. Liang J. Zhang H. Sun L. Mesenchymal SCT ameliorates refractory cytopenia in patients with systemic lupus erythematosus. Bone Marrow Transplant. 2013 48 4 544 550 10.1038/bmt.2012.184 23064040
    [Google Scholar]
  41. Park M.J. Kwok S.K. Lee S.H. Kim E.K. Park S.H. Cho M.L. Adipose tissue-derived mesenchymal stem cells induce expansion of interleukin-10-producing regulatory B cells and ameliorate autoimmunity in a murine model of systemic lupus erythematosus. Cell Transplant. 2015 24 11 2367 2377 10.3727/096368914X685645 25506685
    [Google Scholar]
  42. Alunno A. Montanucci P. Bistoni O. Basta G. Caterbi S. Pescara T. Pennoni I. Bini V. Bartoloni E. Gerli R. Calafiore R. In vitro immunomodulatory effects of microencapsulated umbilical cord Wharton jelly-derived mesenchymal stem cells in primary Sjögren’s syndrome. Rheumatology 2015 54 1 163 168 10.1093/rheumatology/keu292 25065014
    [Google Scholar]
  43. Hai B. Shigemoto-Kuroda T. Zhao Q. Lee R.H. Liu F. Inhibitory effects of iPSC-MSCs and their extracellular vesicles on the onset of sialadenitis in a mouse model of Sjögren’s syndrome Stem Cells Int. 2018 2018 1 2092315 10.1155/2018/2092315 29736173
    [Google Scholar]
  44. Khalili S. Liu Y. Kornete M. Roescher N. Kodama S. Peterson A. Piccirillo C.A. Tran S.D. Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren’s-like disease. Plos One 2012 7 6 e38615 10.1371/journal.pone.0038615 22685592
    [Google Scholar]
  45. Liu R. Su D. Zhou M. Feng X. Li X. Sun L. Umbilical cord mesenchymal stem cells inhibit the differentiation of circulating T follicular helper cells in patients with primary Sjögren’s syndrome through the secretion of indoleamine 2,3-dioxygenase. Rheumatology 2015 54 2 332 342 10.1093/rheumatology/keu316 25169988
    [Google Scholar]
  46. Forbes G.M. Sturm M.J. Leong R.W. Sparrow M.P. Segarajasingam D. Cummins A.G. Phillips M. Herrmann R.P. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn’s disease refractory to biologic therapy. Clin. Gastroenterol. Hepatol. 2014 12 1 64 71 10.1016/j.cgh.2013.06.021 23872668
    [Google Scholar]
  47. González M.A. Gonzalez-Rey E. Rico L. Büscher D. Delgado M. Adipose-derived mesenchymal stem cells alleviate experimental colitis by inhibiting inflammatory and autoimmune responses. Gastroenterology 2009 136 3 978 989 10.1053/j.gastro.2008.11.041 19135996
    [Google Scholar]
  48. Zhang J. Lv S. Liu X. Song B. Shi L. Umbilical cord mesenchymal stem cell treatment for Crohn’s disease: a randomized controlled clinical trial. Gut Liver 2018 12 1 73 78 10.5009/gnl17035 28873511
    [Google Scholar]
  49. Sah S.K. Agrahari G. Nguyen C.T. Kim Y.S. Kang K.S. Kim T.Y. Enhanced therapeutic effects of human mesenchymal stem cells transduced with superoxide dismutase 3 in a murine atopic dermatitis‐like skin inflammation model. Allergy 2018 73 12 2364 2376 10.1111/all.13594 30144097
    [Google Scholar]
  50. Villatoro A.J. Hermida-Prieto M. Fernández V. Fariñas F. Alcoholado C. Rodríguez-García M.I. Mariñas-Pardo L. Becerra J. Allogeneic adipose‐derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: clinical efficacy and safety. Vet. Rec. 2018 183 21 654 654 10.1136/vr.104867 30158120
    [Google Scholar]
  51. Wang M. Yuan Q. Xie L. Mesenchymal Stem Cell-Based Immunomodulation: Properties and Clinical Application. Stem Cells Int. 2018 2018 1 12 10.1155/2018/3057624 30013600
    [Google Scholar]
  52. Yi T. Song S.U. Immunomodulatory properties of mesenchymal stem cells and their therapeutic applications. Arch. Pharm. Res. 2012 35 2 213 221 10.1007/s12272‑012‑0202‑z 22370776
    [Google Scholar]
  53. Li P. Ou Q. Shi S. Shao C. Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications. Cell. Mol. Immunol. 2023 20 6 558 569 10.1038/s41423‑023‑00998‑y 36973490
    [Google Scholar]
  54. Gao F. Chiu S.M. Motan D A L. Zhang Z. Chen L. Ji H-L. Tse H-F. Fu Q-L. Lian Q. Mesenchymal stem cells and immunomodulation: current status and future prospects. Cell Death Dis. 2016 7 1 e2062 e2062 10.1038/cddis.2015.327 26794657
    [Google Scholar]
  55. Plock J.A. Schnider J.T. Solari M.G. Zheng X.X. Gorantla V.S. Perspectives on the use of mesenchymal stem cells in vascularized composite allotransplantation. Front. Immunol. 2013 4 175 10.3389/fimmu.2013.00175 23888159
    [Google Scholar]
  56. Haque N. Kasim N.H.A. Rahman M.T. Optimization of pre-transplantation conditions to enhance the efficacy of mesenchymal stem cells. Int. J. Biol. Sci. 2015 11 3 324 334 10.7150/ijbs.10567 25678851
    [Google Scholar]
  57. Gebler A. Zabel O. Seliger B. The immunomodulatory capacity of mesenchymal stem cells. Trends Mol. Med. 2012 18 2 128 134 10.1016/j.molmed.2011.10.004 22118960
    [Google Scholar]
  58. Duan W.W. Yang L.T. Liu J. Dai Z.Y. Wang Z.Y. Zhang H. Zhang X. Liang X.S. Luo P. Zhang J. Liu Z.Q. Zhang N. Mo H.Y. Qu C.R. Xia Z.W. Cheng Q. A TGF‐β signaling‐related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response. CNS Neurosci. Ther. 2024 30 4 e14489 10.1111/cns.14489 37850692
    [Google Scholar]
  59. Ganguly D. Haak S. Sisirak V. Reizis B. The role of dendritic cells in autoimmunity. Nat. Rev. Immunol. 2013 13 8 566 577 10.1038/nri3477 23827956
    [Google Scholar]
  60. Sozzani S. Del Prete A. Bosisio D. Dendritic cell recruitment and activation in autoimmunity. J. Autoimmun. 2017 85 126 140 10.1016/j.jaut.2017.07.012 28774715
    [Google Scholar]
  61. Shlomchik M.J. Activating systemic autoimmunity: B’s, T’s, and tolls. Curr. Opin. Immunol. 2009 21 6 626 633 10.1016/j.coi.2009.08.005 19800208
    [Google Scholar]
  62. Zaborowski M.P. Balaj L. Breakefield X.O. Lai C.P. Extracellular vesicles: composition, biological relevance, and methods of study. Bioscience 2015 65 8 783 797 10.1093/biosci/biv084 26955082
    [Google Scholar]
  63. Yáñez-Mó M. Siljander P.R.M. Andreu Z. Bedina Zavec A. Borràs F.E. Buzas E.I. Buzas K. Casal E. Cappello F. Carvalho J. Colás E. Cordeiro-da Silva A. Fais S. Falcon-Perez J.M. Ghobrial I.M. Giebel B. Gimona M. Graner M. Gursel I. Gursel M. Heegaard N.H.H. Hendrix A. Kierulf P. Kokubun K. Kosanovic M. Kralj-Iglic V. Krämer-Albers E.M. Laitinen S. Lässer C. Lener T. Ligeti E. Linē A. Lipps G. Llorente A. Lötvall J. Manček-Keber M. Marcilla A. Mittelbrunn M. Nazarenko I. Nolte-’t Hoen E.N.M. Nyman T.A. O’Driscoll L. Olivan M. Oliveira C. Pállinger É. del Portillo H.A. Reventós J. Rigau M. Rohde E. Sammar M. Sánchez-Madrid F. Santarém N. Schallmoser K. Stampe Ostenfeld M. Stoorvogel W. Stukelj R. Van der Grein S.G. Helena Vasconcelos M. Wauben M.H.M. De Wever O. Biological properties of extracellular vesicles and their physiological functions. J. Extracell. Vesicles 2015 4 1 27066 10.3402/jev.v4.27066 25979354
    [Google Scholar]
  64. Cheng Y. Cao X. Qin L. Mesenchymal Stem Cell-Derived Extracellular Vesicles: A Novel Cell-Free Therapy for Sepsis. Front. Immunol. 2020 11 647 10.3389/fimmu.2020.00647 32373121
    [Google Scholar]
  65. Corbeil D. Lorico A. Exosomes, microvesicles, and their friends in solid tumors. Exosomes. Elsevier 2020 39 80 10.1016/B978‑0‑12‑816053‑4.00003‑1
    [Google Scholar]
  66. Jasoria Y. Role of Exosomes in Multiple Sclerosis. Exosomes Based Drug Delivery Strategies for Brain Disorders. Springer 2024 103 121 10.1007/978‑981‑99‑8373‑5_4
    [Google Scholar]
  67. Yu G. Ding J. Yang N. Ge L. Chen N. Zhang X. Wang Q. Liu X. Zhang X. Jiang X. Geng Y. Zhang C. Pan J. Wang X. Gao W. Li Z. Zhang H. Ni W. Xiao J. Zhou K. Yang L. Evaluating the pro-survival potential of apoptotic bodies derived from 2D- and 3D- cultured adipose stem cells in ischaemic flaps. J. Nanobiotechnology 2024 22 1 333 10.1186/s12951‑024‑02533‑1 38877492
    [Google Scholar]
  68. Edgar J.R. Eden E.R. Futter C.E. Hrs- and CD63-dependent competing mechanisms make different sized endosomal intraluminal vesicles. Traffic 2014 15 2 197 211 10.1111/tra.12139 24279430
    [Google Scholar]
  69. Wani T.U. Exosomes Harnessed as Nanocarriers for Cancer Therapy-Current Status and Potential for Future Clinical Applications. Curr. Mol. Med. 2020 ••• 10.2174/1566524020666200915111618 32933459
    [Google Scholar]
  70. Raposo G. Stoorvogel W. Extracellular vesicles: Exosomes, microvesicles, and friends. J. Cell Biol. 2013 200 4 373 383 10.1083/jcb.201211138 23420871
    [Google Scholar]
  71. Kalra H. Drummen G. Mathivanan S. Focus on extracellular vesicles: introducing the next small big thing. Int. J. Mol. Sci. 2016 17 2 170 10.3390/ijms17020170 26861301
    [Google Scholar]
  72. Whittaker T.E. Nagelkerke A. Nele V. Kauscher U. Stevens M.M. Experimental artefacts can lead to misattribution of bioactivity from soluble mesenchymal stem cell paracrine factors to extracellular vesicles. J. Extracell. Vesicles 2020 9 1 1807674 10.1080/20013078.2020.1807674 32944192
    [Google Scholar]
  73. Witwer K.W. Van Balkom B.W.M. Bruno S. Choo A. Dominici M. Gimona M. Hill A.F. De Kleijn D. Koh M. Lai R.C. Mitsialis S.A. Ortiz L.A. Rohde E. Asada T. Toh W.S. Weiss D.J. Zheng L. Giebel B. Lim S.K. Defining mesenchymal stromal cell (MSC)‐derived small extracellular vesicles for therapeutic applications. J. Extracell. Vesicles 2019 8 1 1609206 10.1080/20013078.2019.1609206 31069028
    [Google Scholar]
  74. Zhao M. Kang M. Wang J. Yang R. Zhong X. Xie Q. Zhou S. Zhang Z. Zheng J. Zhang Y. Guo S. Lin W. Huang J. Guo G. Fu Y. Li B. Fan Z. Li X. Wang D. Chen X. Tang B.Z. Liao Y. Stem Cell‐Derived Nanovesicles Embedded in Dual‐Layered Hydrogel for Programmed ROS Regulation and Comprehensive Tissue Regeneration in Burn Wound Healing. Adv. Mater. 2024 36 32 2401369 10.1002/adma.202401369 38822749
    [Google Scholar]
  75. Zhao A.G. Shah K. Cromer B. Sumer H. Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential Stem cells Int 2020 1 8825771 10.1155/2020/8825771 32908543
    [Google Scholar]
  76. Colombo M. Raposo G. Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles. Annu. Rev. Cell Dev. Biol. 2014 30 1 255 289 10.1146/annurev‑cellbio‑101512‑122326 25288114
    [Google Scholar]
  77. Gould S.J. Raposo G. As we wait: coping with an imperfect nomenclature for extracellular vesicles. J. Extracell. Vesicles 2013 2 1 20389 10.3402/jev.v2i0.20389 24009890
    [Google Scholar]
  78. Stahl P.D. Raposo G. Extracellular vesicles: exosomes and microvesicles, integrators of homeostasis. Physiology 2019 34 3 169 177 10.1152/physiol.00045.2018 30968753
    [Google Scholar]
  79. Johnstone R.M. Adam M. Hammond J.R. Orr L. Turbide C. Vesicle formation during reticulocyte maturation. Association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 1987 262 19 9412 9420 10.1016/S0021‑9258(18)48095‑7 3597417
    [Google Scholar]
  80. Barry F.P. Murphy J.M. Mesenchymal stem cells: clinical applications and biological characterization. Int. J. Biochem. Cell Biol. 2004 36 4 568 584 10.1016/j.biocel.2003.11.001 15010324
    [Google Scholar]
  81. Kahmini F.R. Shahgaldi S. Therapeutic potential of mesenchymal stem cell-derived extracellular vesicles as novel cell-free therapy for treatment of autoimmune disorders. Exp. Mol. Pathol. 2021 118 104566 10.1016/j.yexmp.2020.104566 33160961
    [Google Scholar]
  82. Bianco P. “Mesenchymal” stem cells. Annu. Rev. Cell Dev. Biol. 2014 30 1 677 704 10.1146/annurev‑cellbio‑100913‑013132 25150008
    [Google Scholar]
  83. Linares R. Tan S. Gounou C. Arraud N. Brisson A.R. High‐speed centrifugation induces aggregation of extracellular vesicles. J. Extracell. Vesicles 2015 4 1 29509 10.3402/jev.v4.29509 26700615
    [Google Scholar]
  84. Wu M. Ouyang Y. Wang Z. Zhang R. Huang P.H. Chen C. Li H. Li P. Quinn D. Dao M. Suresh S. Sadovsky Y. Huang T.J. Isolation of exosomes from whole blood by integrating acoustics and microfluidics. Proc. Natl. Acad. Sci. USA 2017 114 40 10584 10589 10.1073/pnas.1709210114 28923936
    [Google Scholar]
  85. Doyle L. Wang M. Overview of extracellular vesicles, their origin, composition, purpose, and methods for exosome isolation and analysis. Cells 2019 8 7 727 10.3390/cells8070727 31311206
    [Google Scholar]
  86. Ludwig A.K. De Miroschedji K. Doeppner T.R. Börger V. Ruesing J. Rebmann V. Durst S. Jansen S. Bremer M. Behrmann E. Singer B.B. Jastrow H. Kuhlmann J.D. El Magraoui F. Meyer H.E. Hermann D.M. Opalka B. Raunser S. Epple M. Horn P.A. Giebel B. Precipitation with polyethylene glycol followed by washing and pelleting by ultracentrifugation enriches extracellular vesicles from tissue culture supernatants in small and large scales. J. Extracell. Vesicles 2018 7 1 1528109 10.1080/20013078.2018.1528109 30357008
    [Google Scholar]
  87. Yu L-L. Zhu J. Liu J. A comparison of traditional and novel methods for the separation of exosomes from human samples BioMed. Res. Int. 2018 1 3634563 10.1155/2018/3634563
    [Google Scholar]
  88. Lyu Z. Xin M. Oyston D.R. Xue T. Kang H. Wang X. Wang Z. Li Q. Cause and consequence of heterogeneity in human mesenchymal stem cells: Challenges in clinical application. Pathol. Res. Pract. 2024 260 155354 10.1016/j.prp.2024.155354 38870711
    [Google Scholar]
  89. Böing A.N. van der Pol E. Grootemaat A.E. Coumans F.A.W. Sturk A. Nieuwland R. Single‐step isolation of extracellular vesicles by size‐exclusion chromatography. J. Extracell. Vesicles 2014 3 1 23430 10.3402/jev.v3.23430 25279113
    [Google Scholar]
  90. Del Piccolo N. Placone J. He L. Agudelo S.C. Hristova K. Production of plasma membrane vesicles with chloride salts and their utility as a cell membrane mimetic for biophysical characterization of membrane protein interactions. Anal. Chem. 2012 84 20 8650 8655 10.1021/ac301776j 22985263
    [Google Scholar]
  91. Samah S. Ramasamy K. Lim S. M. Neoh C. F. J. D. r. practice c. Probiotics for the management of type 2 diabetes mellitus: A systematic review and meta-analysis Diab. res. clinic. pract. 2016 118 172 182
    [Google Scholar]
  92. Mao F. Exosomes derived from human umbilical cord mesenchymal stem cells relieve inflammatory bowel disease in mice BioMed Res. Int 2017 2017 10.1155/2017/5356760
    [Google Scholar]
  93. Gomzikova M.O. Rizvanov A.A. Current trends in regenerative medicine: from cell to cell-free therapy. Bionanoscience 2017 7 1 240 245 10.1007/s12668‑016‑0348‑0
    [Google Scholar]
  94. Gomzikova M.O. Aimaletdinov A.M. Bondar O.V. Starostina I.G. Gorshkova N.V. Neustroeva O.A. Kletukhina S.K. Kurbangaleeva S.V. Vorobev V.V. Garanina E.E. Persson J.L. Jeyapalan J. Mongan N.P. Khaiboullina S.F. Rizvanov A.A. Immunosuppressive properties of cytochalasin B-induced membrane vesicles of mesenchymal stem cells: comparing with extracellular vesicles derived from mesenchymal stem cells. Sci. Rep. 2020 10 1 10740 10.1038/s41598‑020‑67563‑9 32612100
    [Google Scholar]
  95. Xu L. Lin M. Li Y. Li S. Chen S. Wei C. Preparation of plasma membrane vesicles from bone marrow mesenchymal stem cells for potential cytoplasm replacement therapy. J. Vis. Exp. 2017 123 e55741 10.3791/55741‑v 28570530
    [Google Scholar]
  96. Robb K.P. Fitzgerald J.C. Barry F. Viswanathan S. Mesenchymal stromal cell therapy: progress in manufacturing and assessments of potency. Cytotherapy 2019 21 3 289 306 10.1016/j.jcyt.2018.10.014 30528726
    [Google Scholar]
  97. Mendt M. Kamerkar S. Sugimoto H. McAndrews K.M. Wu C.C. Gagea M. Yang S. Blanko E.V.R. Peng Q. Ma X. Marszalek J.R. Maitra A. Yee C. Rezvani K. Shpall E. LeBleu V.S. Kalluri R. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight 2018 3 8 e99263 10.1172/jci.insight.99263 29669940
    [Google Scholar]
  98. Brakhage A.A. Zimmermann A.K. Rivieccio F. Visser C. Blango M.G. Host-derived extracellular vesicles for antimicrobial defense. MicroLife 2021 2 uqab003 10.1093/femsml/uqab003 37223251
    [Google Scholar]
  99. Lai P. Weng J. Guo L. Chen X. Du X. Novel insights into MSC-EVs therapy for immune diseases. Biomark. Res. 2019 7 1 6 10.1186/s40364‑019‑0156‑0 30923617
    [Google Scholar]
  100. Lai R.C. Arslan F. Lee M.M. Sze N.S.K. Choo A. Chen T.S. Salto-Tellez M. Timmers L. Lee C.N. El Oakley R.M. Pasterkamp G. de Kleijn D.P.V. Lim S.K. Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury. Stem Cell Res. 2010 4 3 214 222 10.1016/j.scr.2009.12.003 20138817
    [Google Scholar]
  101. Jafarinia M. Alsahebfosoul F. Salehi H. Eskandari N. Ganjalikhani-Hakemi M. Mesenchymal stem cell-derived extracellular vesicles: a novel cell-free therapy. Immunol. Invest. 2020 49 7 758 780 10.1080/08820139.2020.1712416 32009478
    [Google Scholar]
  102. Al Naem M. Bourebaba L. Kucharczyk K. Röcken M. Marycz K. Therapeutic mesenchymal stromal stem cells: Isolation, characterization and role in equine regenerative medicine and metabolic disorders. Stem Cell Rev. Rep. 2020 16 2 301 322 10.1007/s12015‑019‑09932‑0 31797146
    [Google Scholar]
  103. Kang D. Oh S. Ahn S.M. Lee B.H. Moon M.H. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. J. Proteome Res. 2008 7 8 3475 3480 10.1021/pr800225z 18570454
    [Google Scholar]
  104. Zheng G. Huang R. Qiu G. Ge M. Wang J. Shu Q. Xu J. Mesenchymal stromal cell-derived extracellular vesicles: regenerative and immunomodulatory effects and potential applications in sepsis. Cell Tissue Res. 2018 374 1 1 15 10.1007/s00441‑018‑2871‑5 29955951
    [Google Scholar]
  105. Lai R.C. Proteolytic potential of the MSC exosome proteome: implications for an exosome-mediated delivery of therapeutic proteasome Int. J. Prot. 2012 2012
    [Google Scholar]
  106. Burrello J. Monticone S. Gai C. Gomez Y. Kholia S. Camussi G. Stem cell-derived extracellular vesicles and immune-modulation. Front. Cell Dev. Biol. 2016 4 83 10.3389/fcell.2016.00083 27597941
    [Google Scholar]
  107. Bebelman M.P. Smit M.J. Pegtel D.M. Baglio S.R. Biogenesis and function of extracellular vesicles in cancer. Pharmacol. Ther. 2018 188 1 11 10.1016/j.pharmthera.2018.02.013 29476772
    [Google Scholar]
  108. Chandra S. Vimal D. Sharma D. Rai V. Gupta S.C. Chowdhuri D.K. Role of miRNAs in development and disease: Lessons learnt from small organisms. Life Sci. 2017 185 8 14 10.1016/j.lfs.2017.07.017 28728902
    [Google Scholar]
  109. Zhou Y. Li Q. Pan R. Wang Q. Zhu X. Yuan C. Cai F. Gao Y. Cui Y. Regulatory roles of three miRNAs on allergen mRNA expression in Tyrophagus putrescentiae. Allergy 2022 77 2 469 482 10.1111/all.15111 34570913
    [Google Scholar]
  110. Fonsato V. Collino F. Herrera M.B. Cavallari C. Deregibus M.C. Cisterna B. Bruno S. Romagnoli R. Salizzoni M. Tetta C. Camussi G. Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells 2012 30 9 1985 1998 10.1002/stem.1161 22736596
    [Google Scholar]
  111. Ono M. Kosaka N. Tominaga N. Yoshioka Y. Takeshita F. Takahashi R. Yoshida M. Tsuda H. Tamura K. Ochiya T. Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells. Sci. Signal. 2014 7 332 ra63 ra63 10.1126/scisignal.2005231 24985346
    [Google Scholar]
  112. Lee J.K. Park S.R. Jung B.K. Jeon Y.K. Lee Y.S. Kim M.K. Kim Y.G. Jang J.Y. Kim C.W. Exosomes derived from mesenchymal stem cells suppress angiogenesis by down-regulating VEGF expression in breast cancer cells. PLoS One 2013 8 12 e84256 10.1371/journal.pone.0084256 24391924
    [Google Scholar]
  113. Xin H. Li Y. Buller B. Katakowski M. Zhang Y. Wang X. Shang X. Zhang Z.G. Chopp M. Exosome-mediated transfer of miR-133b from multipotent mesenchymal stromal cells to neural cells contributes to neurite outgrowth. Stem Cells 2012 30 7 1556 1564 10.1002/stem.1129 22605481
    [Google Scholar]
  114. Wang J. Xia J. Huang R. Hu Y. Fan J. Shu Q. Xu J. Mesenchymal stem cell-derived extracellular vesicles alter disease outcomes via endorsement of macrophage polarization. Stem Cell Res. Ther. 2020 11 1 424 10.1186/s13287‑020‑01937‑8 32993783
    [Google Scholar]
  115. Bruno S. Deregibus M.C. Camussi G. The secretome of mesenchymal stromal cells: Role of extracellular vesicles in immunomodulation. Immunol. Lett. 2015 168 2 154 158 10.1016/j.imlet.2015.06.007 26086886
    [Google Scholar]
  116. Liu X. Wei Q. Lu L. Cui S. Ma K. Zhang W. Ma F. Li H. Fu X. Zhang C. Immunomodulatory potential of mesenchymal stem cell-derived extracellular vesicles: Targeting immune cells. Front. Immunol. 2023 14 1094685 10.3389/fimmu.2023.1094685 36860847
    [Google Scholar]
  117. Franco da Cunha F. Andrade-Oliveira V. Candido de Almeida D. Borges da Silva T. Naffah de Souza Breda C. Costa Cruz M. Faquim-Mauro E.L. Antonio Cenedeze M. Ioshie Hiyane M. Pacheco-Silva A. Aparecida Cavinato R. Torrecilhas A.C. Olsen Saraiva Câmara N. Extracellular Vesicles isolated from Mesenchymal Stromal Cells Modulate CD4+ T Lymphocytes Toward a Regulatory Profile. Cells 2020 9 4 1059 10.3390/cells9041059 32340348
    [Google Scholar]
  118. Chu H. Du C. Yang Y. Feng X. Zhu L. Chen J. Yang F. MC-LR Aggravates Liver Lipid Metabolism Disorders in Obese Mice Fed a High-Fat Diet via PI3K/AKT/mTOR/SREBP1 Signaling Pathway. Toxins 2022 14 12 833 10.3390/toxins14120833 36548730
    [Google Scholar]
  119. Xu A. NF-κB pathway activation during endothelial-to-mesenchymal transition in a rat model of doxorubicin-induced cardiotoxicity BioPharm 2020 130 110525 10.1016/j.biopha.2020.110525
    [Google Scholar]
  120. Grange C. Tapparo M. Bruno S. Chatterjee D. Quesenberry P.J. Tetta C. Camussi G. Biodistribution of mesenchymal stem cell-derived extracellular vesicles in a model of acute kidney injury monitored by optical imaging. Int. J. Mol. Med. 2014 33 5 1055 1063 10.3892/ijmm.2014.1663 24573178
    [Google Scholar]
  121. Jang S.C. Kim S.R. Yoon Y.J. Park K.S. Kim J.H. Lee J. Kim O.Y. Choi E.J. Kim D.K. Choi D.S. Kim Y.K. Park J. Di Vizio D. Gho Y.S. In vivo kinetic biodistribution of nano-sized outer membrane vesicles derived from bacteria. Small 2015 11 4 456 461 10.1002/smll.201401803 25196673
    [Google Scholar]
  122. Lai C.P. Mardini O. Ericsson M. Prabhakar S. Maguire C.A. Chen J.W. Tannous B.A. Breakefield X.O. Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS Nano 2014 8 1 483 494 10.1021/nn404945r 24383518
    [Google Scholar]
  123. Wiklander O.P.B. Nordin J.Z. O’Loughlin A. Gustafsson Y. Corso G. Mäger I. Vader P. Lee Y. Sork H. Seow Y. Heldring N. Alvarez-Erviti L. Smith C.I.E. Le Blanc K. Macchiarini P. Jungebluth P. Wood M.J.A. Andaloussi S.E.L. Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting. J. Extracell. Vesicles 2015 4 1 26316 10.3402/jev.v4.26316 25899407
    [Google Scholar]
  124. Tamura R. Uemoto S. Tabata Y. Immunosuppressive effect of mesenchymal stem cell-derived exosomes on a concanavalin A-induced liver injury model. Inflamm. Regen. 2016 36 1 26 10.1186/s41232‑016‑0030‑5 29259699
    [Google Scholar]
  125. Cosenza S. Toupet K. Maumus M. Luz-Crawford P. Blanc-Brude O. Jorgensen C. Noël D. Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Theranostics 2018 8 5 1399 1410 10.7150/thno.21072 29507629
    [Google Scholar]
  126. Meng Q. Qiu B. Exosomal MicroRNA-320a Derived From Mesenchymal Stem Cells Regulates Rheumatoid Arthritis Fibroblast-Like Synoviocyte Activation by Suppressing CXCL9 Expression. Front. Physiol. 2020 11 441 441 10.3389/fphys.2020.00441 32528301
    [Google Scholar]
  127. Li Z. Liu F. He X. Yang X. Shan F. Feng J. Exosomes derived from mesenchymal stem cells attenuate inflammation and demyelination of the central nervous system in EAE rats by regulating the polarization of microglia. Int. Immunopharmacol. 2019 67 268 280 10.1016/j.intimp.2018.12.001 30572251
    [Google Scholar]
  128. Jafarinia M. Alsahebfosoul F. Salehi H. Eskandari N. Azimzadeh M. Mahmoodi M. Asgary S. Ganjalikhani Hakemi M. Therapeutic effects of extracellular vesicles from human adipose‐derived mesenchymal stem cells on chronic experimental autoimmune encephalomyelitis. J. Cell. Physiol. 2020 235 11 8779 8790 10.1002/jcp.29721 32329062
    [Google Scholar]
  129. Laso-García F. Ramos-Cejudo J. Carrillo-Salinas F.J. Otero-Ortega L. Feliú A. Gómez-de Frutos M. Mecha M. Díez-Tejedor E. Guaza C. Gutiérrez-Fernández M. Therapeutic potential of extracellular vesicles derived from human mesenchymal stem cells in a model of progressive multiple sclerosis. PLos One 2018 13 9 e0202590 10.1371/journal.pone.0202590 30231069
    [Google Scholar]
  130. Zhu Z. Gu Y. Zeng C. Yang M. Yu H. Chen H. Zhang B. Cai H. Olanzapine-induced lipid disturbances: A potential mechanism through the gut microbiota-brain axis. Front. Pharmacol. 2022 13 897926 10.3389/fphar.2022.897926 35991866
    [Google Scholar]
  131. Shigemoto-Kuroda T. Oh J.Y. Kim D. Jeong H.J. Park S.Y. Lee H.J. Park J.W. Kim T.W. An S.Y. Prockop D.J. Lee R.H. MSC-derived Extracellular Vesicles Attenuate Immune Responses in Two Autoimmune Murine Models: Type 1 Diabetes and Uveoretinitis. Stem Cell Reports 2017 8 5 1214 1225 10.1016/j.stemcr.2017.04.008 28494937
    [Google Scholar]
  132. Bai L. Effects of Mesenchymal Stem Cell-Derived Exosomes on Experimental Autoimmune Uveitis Sci. Rep. 2017 10.1038/s41598‑017‑04559‑y 28659587
    [Google Scholar]
  133. Yang J. Liu X.X. Fan H. Tang Q. Shou Z.X. Zuo D.M. Zou Z. Xu M. Chen Q.Y. Peng Y. Deng S.J. Liu Y.J. Extracellular vesicles derived from bone marrow mesenchymal stem cells protect against experimental colitis via attenuating colon inflammation, oxidative stress and apoptosis. PLoS One 2015 10 10 e0140551 10.1371/journal.pone.0140551 26469068
    [Google Scholar]
  134. Wu Y. Exosomes derived from human umbilical cord mesenchymal stem cells alleviate inflammatory bowel disease in mice through ubiquitination. Am. J. Transl. Res. 2018 10 7 2026 2036 30093940
    [Google Scholar]
  135. Nojehdehi S. Soudi S. Hesampour A. Rasouli S. Soleimani M. Hashemi S.M. Immunomodulatory effects of mesenchymal stem cell–derived exosomes on experimental type‐1 autoimmune diabetes. J. Cell. Biochem. 2018 119 11 9433 9443 10.1002/jcb.27260 30074271
    [Google Scholar]
  136. Bahl G. Upadhyay D.K. Varma M. Singh R. Das S. Hussain S. Persistent chronic calcific pancreatitis with intraductal calculi associated with secondary diabetes mellitus type 3 and diabetic ketoacidosis – A case report. Endocr. Regul. 2024 58 1 101 104 10.2478/enr‑2024‑0011 38656253
    [Google Scholar]
  137. Sabry D. Marzouk S. Zakaria R. Ibrahim H.A. Samir M. The effect of exosomes derived from mesenchymal stem cells in the treatment of induced type 1 diabetes mellitus in rats. Biotechnol. Lett. 2020 42 8 1597 1610 10.1007/s10529‑020‑02908‑y 32430801
    [Google Scholar]
  138. Zhou Y. Dermatophagoides pteronyssinus allergen Der p 22: Cloning, expression, IgE-binding in asthmatic children, and immunogenicity Pediatr. Allergy Immunol. 2022 33 8 e13835 10.1111/pai.13835
    [Google Scholar]
  139. Wang L. Gu Z. Zhao X. Yang N. Wang F. Deng A. Zhao S. Luo L. Wei H. Guan L. Gao Z. Li Y. Wang L. Liu D. Gao C. Extracellular vesicles released from human umbilical cord-derived mesenchymal stromal cells prevent life-threatening acute graft-versus-host disease in a mouse model of allogeneic hematopoietic stem cell transplantation. Stem Cells Dev. 2016 25 24 1874 1883 10.1089/scd.2016.0107 27649744
    [Google Scholar]
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Immunomodulatory Roles of Mesenchymal Stem Cell-derived Extracellular Vesicles: A Promising Therapeutic Approach for Autoimmune Diseases
Bentham Science Publishers ; https://doi.org/10.2174/011574888X341781241216044130
/content/journals/cscr/10.2174/011574888X341781241216044130
/content/journals/cscr/10.2174/011574888X341781241216044130
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  • Article Type:     Review Article
Keywords: tolerance ; inflammation ; biomaterials ; Autoimmunity ; wound healing ; immunotherapy

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