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image of Combined Axial and Peripheral Melorheostosis in a Young Boy: A Unique Case

Abstract

Background

Axial melorheostosis is a rare clinical condition with only a few cases identified worldwide. The combination of axial and peripheral melorheostosis has not reported before, to the best of our knowledge.

Case Presentation

Here, we present a case of a 9-year-old boy, who was referred with pain and swelling over the medial upper right leg with slight limping of insidious onset over a 3-month period. In addition, there was discomfort and irregular patchy skin lesions over the lower back. On examination, a tender swelling with irregular borders was felt over the right upper tibia. A diagnosis of axial and peripheral melorheostosis was confirmed by radiological imaging. A single dose of intravenous zolendronic acid (0.05 mg/kg) was administered. The patient showed significant improvement of symptoms within 2 months of treatment, with complete alleviation of symptoms after 6 months.

Conclusion

Axial and peripheral melorheostosis can present together; however, peripheral lesions may adequately respond to zolendronic acid treatment.

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2025-03-10
2025-04-18

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/content/journals/crr/10.2174/0115733971342621250305173428
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Combined Axial and Peripheral Melorheostosis in a Young Boy: A Unique Case
Bentham Science Publishers ; https://doi.org/10.2174/0115733971342621250305173428
/content/journals/crr/10.2174/0115733971342621250305173428
/content/journals/crr/10.2174/0115733971342621250305173428
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  • Article Type:     Case Report
Keywords: hyperostosis ; zolendronic acid ; Melorheostosis

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