Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Rheumatology Reviews
  4. Fast Track Articles
  5. Fast Track Article
image of Promising Anti-Inflammatory Properties of Ursolic Acid Isolated from Atylosia goensis

Abstract

Introduction

Indigenous plants are plant species that are native to a specific region and have evolved naturally and adapted to local environmental conditions over a long period.

Aim

This study aimed to explore the anti-arthritic effects of , an indigenous plant species in the Western Ghats of India.

Methodology

An ethanolic extract of was obtained using the Soxhlet extraction method, which revealed a diverse array of phytochemicals through liquid chromatography-mass spectroscopy (LC-MS). Key compounds, including fatty acids, sterols, and potential health-beneficial compounds, were identified, and one prominent phytoconstituent, ursolic acid, was spectroscopically characterized using 1H NMR, 13C NMR, and mass spectrometry. The research also examined the anti-inflammatory activity and and anti-arthritic activity of ethanolic extract.

Results

The ethanol extract exhibited notable inhibition of Cox-2, indicating potential anti-inflammatory effects. The anti-arthritic activity of ursolic acid was evaluated at different doses (200 and 400 mg/kg) over a 24-day period. Ursolic acid significantly reduced joint edema, particularly at higher doses, thereby emphasizing its anti-inflammatory properties. Biomarker analysis revealed dose-dependent attenuation of disease-associated biomarker levels, supporting the potential therapeutic efficacy of ursolic acid in arthritis management. Moreover, the hepatoprotective potential of ursolic acid was evident in biochemical parameters, including SGPT, SGOT, and ALP levels. Both doses of ursolic acid effectively mitigated liver dysfunction induced in the disease control group, demonstrating its protective role in liver health. Histopathological assessments corroborated these findings, indicating a reduction in inflammatory areas following ursolic acid treatment, especially at higher doses.

Conclusion

This experimental work provides valuable information on the therapeutic potential of and ursolic acid, emphasizing their roles in anti-inflammatory and hepatoprotective applications. This study contributes to the understanding of plant-derived compounds for potential pharmaceutical use in the management of inflammatory and arthritic conditions.

© 2024 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/crr/10.2174/0115733971320847241017104155
2024-10-24
2025-01-24

  • From This Site

    /content/journals/crr/10.2174/0115733971320847241017104155
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. Ding Q. Hu W. Wang R. Yang Q. Zhu M. Li M. Cai J. Rose P. Mao J. Zhu Y.Z. Signaling pathways in rheumatoid arthritis: implications for targeted therapy. Signal Transduct. Target. Ther. 2023 8 1 68 10.1038/s41392‑023‑01331‑9 36797236
    [Google Scholar]
  2. Yang C. Li D. Teng D. Zhou Y. Zhang L. Zhong Z. Yang G.J. Epigenetic regulation in the pathogenesis of rheumatoid arthritis. Front. Immunol. 2022 13 859400 10.3389/fimmu.2022.859400 35401513
    [Google Scholar]
  3. Jang D. Lee A.H. Shin H.Y. Song H.R. Park J.H. Kang T.B. Lee S.R. Yang S.H. The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. Int. J. Mol. Sci. 2021 22 5 2719 10.3390/ijms22052719 33800290
    [Google Scholar]
  4. Abdulkhaleq L.A. Assi M.A. Abdullah R. Zamri-Saad M. Taufiq-Yap Y.H. Hezmee M.N.M. The crucial roles of inflammatory mediators in inflammation: A review. Vet. World 2018 11 5 627 635 10.14202/vetworld.2018.627‑635 29915501
    [Google Scholar]
  5. Angum F. Khan T. Kaler J. Siddiqui L. Hussain A. The prevalence of autoimmune disorders in women: A narrative review. Cureus 2020 12 5 e8094 10.7759/cureus.8094 32542149
    [Google Scholar]
  6. Yeshi K. Turpin G. Jamtsho T. Wangchuk P. Indigenous uses, phytochemical analysis, and anti-inflammatory properties of australian tropical medicinal plants. Molecules 2022 27 12 3849 10.3390/molecules27123849 35744969
    [Google Scholar]
  7. Mata L. Andersen A.N. Morán-Ordóñez A. Hahs A.K. Backstrom A. Ives C.D. Bickel D. Duncan D. Palma E. Thomas F. Cranney K. Walker K. Shears I. Semeraro L. Malipatil M. Moir M.L. Plein M. Porch N. Vesk P.A. Smith T.R. Lynch Y. Indigenous plants promote insect biodiversity in urban greenspaces. Ecol. Appl. 2021 31 4 e02309 10.1002/eap.2309 33605502
    [Google Scholar]
  8. Nunes C.R. Barreto Arantes M. Menezes de Faria Pereira S. Leandro da Cruz L. de Souza Passos M. Pereira de Moraes L. Vieira I.J.C. Barros de Oliveira D. Plants as sources of anti-inflammatory agents. Molecules 2020 25 16 3726 10.3390/molecules25163726 32824133
    [Google Scholar]
  9. Parham S. Kharazi A.Z. Bakhsheshi-Rad H.R. Nur H. Ismail A.F. Sharif S. RamaKrishna S. Berto F. Antioxidant, antimicrobial and antiviral properties of herbal materials. Antioxidants 2020 9 12 1309 10.3390/antiox9121309 33371338
    [Google Scholar]
  10. Rodríguez-Yoldi M.J. Anti-inflammatory and antioxidant properties of plant extracts. Antioxidants 2021 10 6 921 10.3390/antiox10060921 34200199
    [Google Scholar]
  11. Raj A.J. Biswakarma S. Pala N.A. Shukla G. Vineeta Kumar M. Chakravarty S. Bussmann R.W. Indigenous uses of ethnomedicinal plants among forest-dependent communities of northern Bengal, India. J. Ethnobiol. Ethnomed. 2018 14 1 8 10.1186/s13002‑018‑0208‑9 29373997
    [Google Scholar]
  12. Díaz-José J. Guevara-Hernández F. Morales-Ríos V. López-Ayala J.L. Traditional knowledge of edible wild plants used by indigenous communities in zongolica, Mexico. Ecol. Food Nutr. 2019 58 5 511 526 10.1080/03670244.2019.1604340 31014104
    [Google Scholar]
  13. VP S Vilgeena W, Alby Babu E, Nidhina D, Meena K. in-vitro antioxidant and cytotoxicity (sk-mel-3 cell) activity of green synthesised copper nanoparticle using P. pellucida plant aqueous extract. Nanomedicine Research Journal. 2021 6 3 279 286
    [Google Scholar]
  14. Banerjee S. Mazumdar S. Electrospray ionization mass spectrometry: A technique to access the information beyond the molecular weight of the analyte. Int. J. Anal. Chem. 2012 2012 1 40 10.1155/2012/282574 22611397
    [Google Scholar]
  15. Sunnapu P. Valiyaparambil S. Kotakonda M. Yogananthan D. Benson S.T. Extraction, isolation, and structural elucidation of novel phytoconstituents from ficus auriculata Lour. Curr. Biotechnol. 2022 11 2 131 139 10.2174/2211550111666220427115157
    [Google Scholar]
  16. Rudrapal M. Eltayeb W.A. Rakshit G. El-Arabey A.A. Khan J. Aldosari S.M. Alshehri B. Abdalla M. Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies. Sci. Rep. 2023 13 1 8656 10.1038/s41598‑023‑35161‑0 37244921
    [Google Scholar]
  17. Walker M.C. Gierse J.K. in vitro assays for cyclooxygenase activity and inhibitor characterization. Methods Mol. Biol. 2010 644 131 144 10.1007/978‑1‑59745‑364‑6_11 20645170
    [Google Scholar]
  18. Laufer S. Luik S. Different methods for testing potential cyclooxygenase-1 and cyclooxygenase-2 inhibitors. Methods Mol. Biol. 2010 644 91 116 10.1007/978‑1‑59745‑364‑6_8 20645167
    [Google Scholar]
  19. Keystone E.C. Schorlemmer H.U. Pope C. Allison A.C. Zymosan-induced arthritis: a model of chronic proliferative arthritis following activation of the alternative pathway of complement. Arthritis Rheum. 1977 20 7 1396 1401 10.1002/art.1780200714 911357
    [Google Scholar]
  20. Thavarajah R. Mudimbaimannar V. Elizabeth J. Rao U. Ranganathan K. Chemical and physical basics of routine formaldehyde fixation. J. Oral Maxillofac. Pathol. 2012 16 3 400 405 10.4103/0973‑029X.102496 23248474
    [Google Scholar]
  21. Checker R. Sandur S.K. Sharma D. Patwardhan R.S. Jayakumar S. Kohli V. Sethi G. Aggarwal B.B. Sainis K.B. Potent anti-inflammatory activity of ursolic acid, a triterpenoid antioxidant, is mediated through suppression of NF-κB, AP-1 and NF-AT. PLoS One 2012 7 2 e31318 10.1371/journal.pone.0031318 22363615
    [Google Scholar]
  22. Ghosh S. Das Sarma M. Patra A. Hazra B. Anti-inflammatory and anticancer compounds isolated from Cissampelos pareira through bioassay-guided fractionation. J. Ethnopharmacol. 2010 131 2 363 371 20633630
    [Google Scholar]
  23. Manjrekar P.N. Jolly C.I. Narayanan S. Comparative studies of the immunomodulatory activity of Tinospora cordifolia and Pterocarpus marsupium extracts. J. Ethnopharmacol. 2000 70 2 133 139
    [Google Scholar]
  24. Machado D.G. Cunha M.P. Neis V.B. Balen G.O. Colla A. Bettio L.E. Antidepressant-like effects of Rosmarinus officinalis in mice: Involvement of the monoaminergic system. Prog. Neuropsychopharmacol. Biol. Psychiatry 2013 47 213 220
    [Google Scholar]
  25. Shukla A. Rasik A.M. Jain G.K. Shankar R. Kulshrestha D.K. Dhawan B.N. in vitro and in vivo wound healing activity of asiaticoside isolated from Centella asiatica. J. Ethnopharmacol. 1999 65 1 1 11 10.1016/S0378‑8741(98)00141‑X 10350364
    [Google Scholar]
  26. Ammon H.P. Safayhi H. Mack T. Sabieraj J. Mechanism of anti-inflammatory actions of Boswellic acids: inhibition of 5-lipoxygenase. J. Pharmacol. Exp. Ther. 1993 267 3 1609 1615
    [Google Scholar]
/content/journals/crr/10.2174/0115733971320847241017104155
Loading
Promising Anti-Inflammatory Properties of Ursolic Acid Isolated from Atylosia goensis
Bentham Science Publishers ; https://doi.org/10.2174/0115733971320847241017104155
/content/journals/crr/10.2174/0115733971320847241017104155
/content/journals/crr/10.2174/0115733971320847241017104155
Loading

Data & Media loading...


  • Article Type:     Research Article
Keywords: in-vivo anti-arthritis activity ; ursolic acid ; Atylosia goensis ; cyclooxygenase-1 ; ethanolic extraction ; cyclooxygenase-2

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test