Skip to content
2000
  1. Home
  2. A-Z Publications
  3. Current Rheumatology Reviews
  4. Volume 21, Issue 2
  5. Article
Volume 21, Issue 2
  • ISSN: 1573-3971
  • E-ISSN: 1875-6360

Abstract

Background

Temporomandibular joint osteoarthritis (TMJ OA) is a chronic disease that is a consequence of undue occlusal forces and is characterized by irreversible damage to the articular surfaces. Symptomatic slow-acting so-called nutraceutical drugs have been proposed as a treatment for osteoarthritis in comparison to non-steroidal anti-inflammatory drugs (NSAIDs). Oral glucosamine and chondroitin, slow-acting drugs, have been found to reduce pain and increase mouth opening in patients with TMJ OA. However, there is limited scientific evidence to confirm their clinical effectiveness.

Aim

This systematic review was conducted to bolster the evidence supporting the assessment of the efficacy of glucosamine in the context of temporomandibular joint osteoarthritis (TMJ OA).

Methodology

This review identified four review articles from databases like Medline ( PubMed), Web of Science, Scopus, and EMBASE till September 2023 after screening at the title, abstract, and full-text level. They were assessed for risk of bias with the JBI risk of bias assessment tool.

Results

This review with meta-analysis focused on pooled estimate mean differences, revealing non-significant but discernible effects of glucosamine on maximum mouth opening (SMD = 0.288, = 0.15) and pain reduction (SMD = 0.217, = 0.476) in TMJ-related disorders.

Conclusion

Compared to control groups with ibuprofen and tramadol, glucosamine showed slightly more favourable outcomes. However, the variability in methodology and study characteristics warrants further longitudinal studies to confirm its efficacy.

© 2025 Bentham Science Publishers
Loading

Article metrics loading...

/content/journals/crr/10.2174/0115733971309907240527105306
2025-06-10
2025-05-13

  • From This Site

    /content/journals/crr/10.2174/0115733971309907240527105306
    dcterms_title,dcterms_subject,pub_keyword
    -contentType:Contributor -contentType:Concept -contentType:Institution
    10
    5
Loading full text...

Full text loading...

References

  1. GuzmanU. GremillionH.A. Temporomandibular disorders: Epidemiologic and etiologic considerations (Part 1).Dental Tribune.20072003810
     [Google Scholar]
  2. HuskissonE.C. Glucosamine and chondroitin for osteoarthritis.J. Int. Med. Res.20083661161117910.1177/14732300080360060219094424
     [Google Scholar]
  3. CribbsB. Glucosamine: An alternative therapy for osteoarthritis?.Nutrition Bytes.19995214
     [Google Scholar]
  4. Damlarİ. EsenE. TatliU. Effects of glucosamine-chondroitin combination on synovial fluid IL-1β, IL-6, TNF-α and PGE2 levels in internal derangements of temporomandibular joint.Med. Oral Patol. Oral Cir. Bucal2015203e278e28310.4317/medoral.2024225662545
     [Google Scholar]
  5. SivakumarS. SivakumarG. SundramoorthyA.K. Effects of glucosamine in the temporomandibular joint osteoarthritis: A review.Curr. Rheumatol. Rev.202420437337810.2174/011573397128300923122514432238213156
     [Google Scholar]
  6. DerwichM. GórskiB. AmmE. PawłowskaE. Oral glucosamine in the treatment of temporomandibular joint osteoarthritis: A systematic review.Int. J. Mol. Sci.2023245492510.3390/ijms2405492536902359
     [Google Scholar]
  7. ChristidisN. Al-MoraissiE.A. BarjandiG. SvedenlöfJ. JasimH. ChristidisM. CollinM. Pharmacological treatments of temporomandibular disorders: A systematic review including a network meta-analysis.Drugs2024841598110.1007/s40265‑023‑01971‑938103150
     [Google Scholar]
  8. EdoardoA. Ritin S. ChristinaG. CherylH. HananK. PatrapornT. Methodology for JBI umbrella reviewsJoanna Briggs Institute Reviewers' ManualAustralia2014134
     [Google Scholar]
  9. AromatarisE. FernandezR. GodfreyC. HollyC. KhalilH. TungpunkomP. Umbrella Reviews. JBI Manual for Evidence Synthesis.Chapter 10 AromatarisE. MunnZ. JBI2020
     [Google Scholar]
  10. BorensteinM. HedgesL. HigginsJ. RothsteinH. Comprehensive Meta-Analysis Version 3.0BiostatEnglewood, NJ2022
     [Google Scholar]
  11. HigginsJ.P.T. ThompsonS.G. Quantifying heterogeneity in a meta- analysis.Stat. Med.200221111539155810.1002/sim.118612111919
     [Google Scholar]
  12. Ruiz-RomeroV. Toledano-SerrabonaJ. Gay-EscodaC. Efficacy of the use of chondroitin sulphate and glucosamine for the treatment of temporomandibular joint dysfunction: A systematic review and meta-analysis.Cranio2022202211010.1080/08869634.2022.207679635588467
     [Google Scholar]
  13. MeloG. CasettE. Stuginski-BarbosaJ. GuerraE.N.S. FernandesD.A. PorporattiA.L. Flores-MirC. De Luca CantoG. Effects of glucosamine supplements on painful temporomandibular joint osteoarthritis: A systematic review.J. Oral Rehabil.201845541442210.1111/joor.1261629446485
     [Google Scholar]
  14. GouzeJ.N. BordjiK. GulbertiS. TerlainB. NetterP. MagdalouJ. Fournel-GigleuxS. OuzzineM. Interleukin-1β down-regulates the expression of glucuronosyltransferase I, a key enzyme priming glycosaminoglycan biosynthesis: Influence of glucosamine on interleukin-1β-mediated effects in rat chondrocytes.Arthritis Rheum.200144235136010.1002/1529‑0131(200102)44:2<351::AID‑ANR53>3.0.CO;2‑M11229466
     [Google Scholar]
  15. PavelkaK. GatterovaJ. OlejarovaM. MachacekS. GiacovelliG. RovatiL.C. Glucosamine sulfate use and delay of progression of knee osteoarthritis: A 3- year, randomized, placebo-controlled, double-blind study.Arch. Intern. Med.200216218e2123
     [Google Scholar]
  16. ShikhmanA.R. Glucosamine and osteoarthritis.Int. J. Clin. Rheumatol.20061167
     [Google Scholar]
  17. de BontL.G.M. LiemR.S.B. HavingaP. BoeringG. Fibrous component of the temporomandibular joint disk.Cranio19853436837310.1080/08869634.1985.116781193864873
     [Google Scholar]
  18. ThieN.M. PrasadN.G. MajorP.W. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: A randomized double blind controlled 3 month clinical trial.J. Rheumatol.20012861347135511409130
     [Google Scholar]
  19. Cömert KılıçS. Does glucosamine, chondroitin sulfate, and methylsulfonylmethane supplementation improve the outcome of temporomandibular joint osteoarthritis management with arthrocentesis plus intraarticular hyaluronic acid injection. A randomized clinical trial.J. Craniomaxillofac. Surg.202149871171810.1016/j.jcms.2021.02.01233685850
     [Google Scholar]
  20. YangW. LiuW. MiaoC. SunH. LiL. LiC. Oral glucosamine hydrochloride combined with hyaluronate sodium intra-articular injection for temporomandibular joint osteoarthritis: A double-blind randomized controlled trial.J. Oral Maxillofac. Surg.201876102066207310.1016/j.joms.2018.04.03129864430
     [Google Scholar]
  21. CenX. LiuY. WangS. YangX. ShiZ. LiangX. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis.Oral Dis.201824340441110.1111/odi.1276028862770
     [Google Scholar]
  22. CahlinB.J. DahlströmL. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints—a randomized, controlled, short-term study.Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod.2011112676076610.1016/j.tripleo.2011.06.01222001199
     [Google Scholar]
  23. NguyenP. MohamedS.E. GardinerD. SalinasT. A randomized double-blind clinical trial of the effect of chondroitin sulfate and glucosamine hydrochloride on temporomandibular joint disorders: A pilot study.Cranio200119213013910.1080/08869634.2001.1174616211842864
     [Google Scholar]
  24. BehniaA. HaghighatA. KavianiN. KhoramiB. Evaluation of Glucosamine sulfate and Ibuprofen effects in patients with temporomandibular joint osteoarthritis symptom.J. Res. Pharm. Pract.201321343910.4103/2279‑042X.11408724991602
     [Google Scholar]
  25. DahmerS. SchillerR.M. Glucosamine.Am. Fam. Physician200878447147618756654
     [Google Scholar]
  26. de SouzaRF da SilvaCH NasserM FedorowiczZ Al-MuharraqiMA Interventions for managing temporomandibular joint osteoarthritis.Cochrane Database Syst Rev201220124CD00726110.1002/14651858.CD007261.pub2
     [Google Scholar]
/content/journals/crr/10.2174/0115733971309907240527105306
Loading
Efficiency of Glucosamine in Treating Temporomandibular Joint Osteoarthritis: A Meta-Analytic Umbrella Review
Curr. Rheumatol. Rev. 21, 194 (2025); https://doi.org/10.2174/0115733971309907240527105306
/content/journals/crr/10.2174/0115733971309907240527105306
/content/journals/crr/10.2174/0115733971309907240527105306
Loading

Data & Media loading...

Supplements

PRISMA checklist is available as supplementary material on the publisher’s website along with the published article.

file format download Download

  • Article Type:     Review Article
Keyword(s): glucosamine; Osteoarthritis; splint therapies, chronic disease; systematic review; temporomandibular joint

Most Cited Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test