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Volume 21, Issue 1
  • ISSN: 1573-3971
  • E-ISSN: 1875-6360

Abstract

Background

Osteoarthritis (OA) is becoming a major medical burden worldwide due to changing lifestyles and aging populations. Osteoarthritis is a disease characterized by a variety of anatomic and physiological changes to joints, including cartilage degradation, bone remodeling, and the formation of osteophytes. These changes cause pain, stiffness, swelling, and limitations in joint function. Glucosamine serves as a fundamental constituent for cartilage, the resilient connective tissue responsible for cushioning joints. Glucosamine Sulphate Potassium Chloride (GSPC) supplementation is widely employed to mitigate symptoms linked to osteoarthritis, a degenerative joint disorder hallmarked by cartilage degradation.

Aim

Palliative care aims at minimizing pain and disability and improving function, performance, and quality of life. In this study, the emulgel formulation of GSPC was developed and checked for its potential.

Objective

Currently, OA does not have a definitive treatment. Since conventional dosage forms cannot deliver the active drug content at a predefined target site in a predictable manner throughout the treatment period, a new carrier system is always required. Considering their reduced size, targeting potential, and site specificity, nanocarrier-based approaches could hold an answer to shortcomings associated with conventional routes. Thus, the objective of the current study was to formulate and characterize glucosamine sulphate potassium chloride-loaded emulgel for the treatment of osteoarthritis.

Methods

Microemulsion of glucosamine sulphate potassium chloride was formulated using a spontaneous emulsification method comprising of oleic acid (oil phase), Tween 80, Tween 20 (surfactant) and PEG 400, Span 80 (co-surfactant), and distilled water (aqueous phase). The microemulsions were evaluated for surface morphology, globule size, poly-dispersibility index (PDI), zeta potential, and viscosity, and the final batch of microemulsions was selected.

Results

The optimized microemulsion contained 35% co-surfactant (propylene glycol), 20% surfactant (Tween 20), and 15% oil (oleic acid) and glucosamine sulphate potassium chloride in a dose of 60 mg, which has sufficient drug loading capacity with a droplet size of 182 nm for optimized formulation. The optimized microemulsion formulation was added to gel prepared by Carbopol 934 in a 1:1 () ratio, leading to the formulation of glucosamine sulphate potassium chloride-containing emulgel. The prepared emulgel was further evaluated for viscosity, drug content, pH, and drug release. Emulgel formulation (F6) showed 88% drug release after 6 hours, and it followed the Higuchi model.

Conclusion

Glucosamine Sulphate Potassium Chloride (GSPC) is used in the treatment of OA by increasing the production of proteoglycans, which can cause the cartilage to break down. Emulgel formulation (F3) showed 75.41% drug release, and formulation (F6) showed 88% drug release after 6 h. Therefore, it may be concluded that an emulgel of GSPC can be used as a controlled-release dosage form of the drug for local application in OA.

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2024-04-03
2025-05-21

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References

  1. MeiH. CaiS. HuangD. GaoH. CaoJ. HeB. Carrier-free nanodrugs with efficient drug delivery and release for cancer therapy: From intrinsic physicochemical properties to external modification.Bioact. Mater.2022822024010.1016/j.bioactmat.2021.06.03534541398
     [Google Scholar]
  2. Sharadha M GowdaD.V. Vishal GuptaN. AkhilaA.R. Gowda D V Vishal Gupta N Akhila A R An overview on topical drug delivery system – Updated review.Int. J. Pharm. Sci. Res.202011136838510.26452/ijrps.v11i1.1831
     [Google Scholar]
  3. CharyuluN.R. JoshiP. DubeyA. ShettyA. Emulgel: A boon for enhanced topical drug delivery.J. Young Pharm.2021131767910.5530/jyp.2021.13.17
     [Google Scholar]
  4. PandeyP. RamkishanA. DurejaH. Optimizing the formulation variables for erlotinib loaded chitosan nanoparticles.Int. J. Pharm. Sci. Res.201891252345239
     [Google Scholar]
  5. KushwahaN. Use of nanotechnology in cosmeceuticals: A review.Int. J. Pharm. Sci. Invent.202009014351
     [Google Scholar]
  6. MinochaN. KumarV. Nanostructure system: Liposome – A bioactive carrier in drug delivery systems.Mater. Today Proc.20226961461910.1016/j.matpr.2022.09.494
     [Google Scholar]
  7. KumarV. MinochaN. GargV. DurejaH. Nanostructured materials used in drug delivery.Mater. Today Proc.20226917418010.1016/j.matpr.2022.08.306
     [Google Scholar]
  8. PandeyP. PurohitD. SharmaS. LambaA.K. SainiS. MinochaN. VashistN. KaushikD. Nanocrystals: A deep insight into formulation aspects, stabilization strategies, and biomedical applications.Recent Pat. Nanotechnol.202317430732610.2174/187221051666622052312031335616680
     [Google Scholar]
  9. MinochaN. SharmaN. VermaR. KaushikD. PandeyP. Solid lipid nanoparticles: Peculiar strategy to deliver bio-proactive molecules.Recent Pat. Nanotechnol.202317322824210.2174/187221051666622031714335135301957
     [Google Scholar]
  10. BhowmikD. Recent advances in novel topical drug delivery system.Pharma Innov.201219
     [Google Scholar]
  11. ImranK.T. GoreS. GiradkarP. A review advances in topical drug delivery system.Int J Pharm Res Allied Sci201111423
     [Google Scholar]
  12. JaniR. JaniK. MallikarjunaS.C. PatelD. Preparation and evaluation of topical gel valdecoxib.Int. J. Pharm. Sci. Res.2010215154
     [Google Scholar]
  13. PathanI.B. SettyC.M. Chemical penetration enhancers for transdermal drug delivery systems.Trop. J. Pharm. Res.20098210.4314/tjpr.v8i2.44527
     [Google Scholar]
  14. ThomasJ. KuppuswamyS. SahibA. BenedictA. GeorgeE. A review on emulgel as a current trend in topical drug delivery systems.Int J Pharmacol Res201793273281
     [Google Scholar]
  15. ZhouX. HaoY. YuanL. PradhanS. ShresthaK. PradhanO. LiuH. LiW. Nano-formulations for transdermal drug delivery: A review.Chin. Chem. Lett.201829121713172410.1016/j.cclet.2018.10.037
     [Google Scholar]
  16. AbdoJ.M. SopkoN.A. MilnerS.M. The applied anatomy of human skin: A model for regeneration.Wound Medicine20202810017910.1016/j.wndm.2020.100179
     [Google Scholar]
  17. MagboolF.F. ElnimaE.I. ShayoubM.E. HamedelnielE.I. Design, formulation, and evaluation of Carbopol 940 and xanthan gum as gel bases for oral local drug delivery for oral mucosal infectious diseases.Eur J Biomed PharmSci2018510921
     [Google Scholar]
  18. KumarD. SinghJ. AntilM. KumarV. Emulgel-novel topical drug delivery system–a comprehensive review.Int. J. Pharm. Sci. Res.201671247334742
     [Google Scholar]
  19. KaushikD. PandeyP. MinochaN. VashistN. ShahR. SainiS. MakhijaM. PurohitD. Emulgel: An emerging approach towards effective topical drug delivery.Drug Deliv. Lett.202212422724210.2174/2210303112666220818115231
     [Google Scholar]
  20. RaoK. MinochaN. Glucosamine sulphate potassium chloride in the management of osteoarthritis- considering emulgel dosage form: A review.Curr. Nutr. Food Sci.202319441942710.2174/1573401318666220601150053
     [Google Scholar]
  21. TorregrosaA. Ochoa-AndradeA.T. ParenteM.E. VidarteA. GuarinoniG. SavioE. Development of an emulgel for the treatment of rosacea using quality by design approach.Drug Dev. Ind. Pharm.202046229630810.1080/03639045.2020.171751531944126
     [Google Scholar]
  22. JainS.K. BajapiP. ModiS.K. GuptaP. A review on emulgel, as a novel trend in topical drug delivery system.Recent Trends PharmSci Res2019123039
     [Google Scholar]
  23. HunterD.J. Bierma-ZeinstraS. Osteoarthritis.Lancet2019393101821745175910.1016/S0140‑6736(19)30417‑931034380
     [Google Scholar]
  24. ReginsterJ.Y. NeuprezA. LecartM.P. SarletN. BruyereO. Role of glucosamine in the treatment for osteoarthritis.Rheumatol. Int.201232102959296710.1007/s00296‑012‑2416‑222461188
     [Google Scholar]
  25. EckertT. Jährling-ButkusM. LoutonH. Burg-RoderfeldM. ZhangR. ZhangN. HesseK. PetridisA.K. KožárT. SteinmeyerJ. SchauerR. EngelhardP. KozarovaA. HudsonJ.W. SiebertH.C. Efficacy of chondroprotective food supplements based on collagen hydrolysate and compounds isolated from marine organisms.Mar. Drugs2021191054210.3390/md1910054234677442
     [Google Scholar]
  26. PikoszK. NowakI. Feliczak-GuzikA. Potential of icariin–glucosamine combination in the treatment of osteoarthritis by topical application: Development of topical formulation and in vitro permeation study.Cosmetics20231013610.3390/cosmetics10010036
     [Google Scholar]
  27. JeroschJ. Effects of glucosamine and chondroitin sulfate on cartilage metabolism in OA: outlook on other nutrient partners especially omega-3 fatty acids.Int. J. Rheumatol.2011201111710.1155/2011/96901221826146
     [Google Scholar]
  28. CohenM. WolfeR. MaiT. LewisD. A randomized, double blind, placebo controlled trial of a topical cream containing glucosamine sulfate, chondroitin sulfate, and camphor for osteoarthritis of the knee.J. Rheumatol.200330352352812610812
     [Google Scholar]
  29. ZhangN. LiuC. JinL. ZhangR. SiebertH.C. WangZ. PrakashS. YinX. LiJ. HouD. SunB. LiuM. Influence of long-chain/medium-chain triglycerides and whey protein/Tween 80 ratio on the stability of phosphatidylserine emulsions (O/W).ACS Omega20205147792780110.1021/acsomega.9b0370232309688
     [Google Scholar]
  30. KasiramarG.K. KomalaS. SoundaryaR. ParthibanS. BharathiB. ElangoS. Review on emulgel formulations with nonsteroidal anti-inflammatory drugs for topical administration.Pharma Sci. Monitor201581238254
     [Google Scholar]
  31. KaleS.N. DeoreS.L. Emulsion, microemulsion, and nanoemulsion: A review.Syst. Rev. Pharm.201681394710.5530/srp.2017.1.8
     [Google Scholar]
  32. AnandK. RayS. RahmanM. ShaharyarA. BhowmikR. BeraR. KarmakarS. Nano-emulgel: Emerging as a smarter topical lipidic emulsion-based nanocarrier for skin healthcare applications.Recent Patents Anti-Infect. Drug Disc.2019141163510.2174/1574891X1466619071711153131333141
     [Google Scholar]
  33. latha SamalaM. SrideviG. Role of polymers as gelling agents in the formulation of Emulgels.Polymer science2016211810.4172/2471‑9935.100010
     [Google Scholar]
  34. BanyalM. JoshiS. Emulgel: An enormous approach for topical delivery of hydrophobic drugs.World J. Pharm. Res.2020913529550
     [Google Scholar]
  35. RajuK. SnehaG. KhatoonR. AshwiniM. ShirishaG. AjayB. BongoniR.N. Formulation and evaluation of ornidazole topical emulgel.World J. Pharm. Pharm. Sci.2019811791197
     [Google Scholar]
  36. ShankarD. DhobaleS. ShelkeG. GajananJ. SureshJ. GaikwadD. Formulation and evaluation of luliconazole emulgel for topical drug delivery.Int Res J Sci Eng201838589
     [Google Scholar]
  37. TanajiD.N. Emulgel: A comprehensive review for topical delivery of hydrophobic drugs.Asian J. Pharm.20181202
     [Google Scholar]
  38. PakhareA.V. DeshmaneS.V. DeshmaneS.S. BiyaniK.R. Design and development of emulgel preparation containing diclofenac potassium.Asian J. Pharm.20171104712716
     [Google Scholar]
  39. ChimeS.A. KenechukwuF.C. AttamaA.A. Nanoemulsions—advances in formulation, characterization and applications in drug delivery.In: Application of Nanotechnology in Drug DeliveryInTech2014377126
     [Google Scholar]
  40. SchleckJ.R. BurgerC.M. ChopdekarV.M. Glucosamine sulfate potassium chloride and process of preparation thereof.U.S. Patent US5843923A1998
  41. National Center for Biotechnology Information PubChem Compound Summary for CID 76965765, Glucosamine Sulfate Potassium Chloride. Available from: https://pubchem.ncbi.nlm.nih.gov/compound/Glucosamine-Sulfate-Potassium-Chloride
/content/journals/crr/10.2174/0115733971291114240326042453
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Formulation and Characterization of Glucosamine Sulphate Potassium Chloride (GSPC) Loaded Emulgel for the Treatment of Osteoarthritis
Curr. Rheumatol. Rev. 21, 97 (2025); https://doi.org/10.2174/0115733971291114240326042453
/content/journals/crr/10.2174/0115733971291114240326042453
/content/journals/crr/10.2174/0115733971291114240326042453
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  • Article Type:     Research Article
Keyword(s): Emulgel; glucosamine sulphate potassium chloride, cartilage degradation, controlled-release dosage; microemulsion; osteoarthritis

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