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Volume 21, Issue 2
  • ISSN: 1875-6921
  • E-ISSN: 1875-6913

Abstract

Background

Osteoporosis is a multifactorial disorder where genetic and environmental factors contribute to changes in bone mineral density. Several genetic polymorphisms are associated with low bone mineral density and osteoporosis risk, including estrogen receptor-α and single nucleotide polymorphisms.

Objective

To determine the allele frequencies of these polymorphisms among postmenopausal Jordanian women and to assess their association with low bone mineral density and osteoporosis among studied subjects.

Methods

This cross-sectional study enrolled 450 postmenopausal Jordanian women having dual-energy X-ray absorptiometry scans at the National Center for Diabetes, Endocrinology, and Genetics. The study protocol was approved by this center “Institutional Review Board.” The estrogen receptor-α gene sequence containing and polymorphisms was identified by polymerase chain reaction, followed by restriction fragment length polymorphism.

Results

The wild-type allele frequencies of () and () were 54% and 59%, respectively. The genotype was significantly associated with lower femoral neck T-scores in women who were postmenopausal for more than 10 years ( = 0.023) and was significantly associated with lower lumbar spine ( = 0.033) and femoral neck ( = 0.002) T-scores in women older than 60 years of age. However, there was no association between , , or their haplotypes with osteoporosis or bone mineral density T-score values. The two polymorphisms were in Hardy-Weinberg equilibrium and exhibited strong but incomplete linkage disequilibrium.

Conclusion

The data suggest that polymorphism may render some women more susceptible to osteoporosis than others.

© 2024 Bentham Science Publishers
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2024-08-01
2025-02-17

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/content/journals/cppm/10.2174/0118756921315583240906100230
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Estrogen Receptor-αrs9340799 Polymorphism Influences Bone Mineral Density in Women Over 60 Years of Age and Women Who are Postmenopausal for More than 10 Years
Current Pharmacogenomics and Personalized Medicine (Formerly Current Pharmacogenomics) 21, 113 (2024); https://doi.org/10.2174/0118756921315583240906100230
/content/journals/cppm/10.2174/0118756921315583240906100230
/content/journals/cppm/10.2174/0118756921315583240906100230
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  • Article Type:     Research Article
Keyword(s): Bone mineral density; estrogen receptor-α; osteoporosis; polymerase chain reaction; restriction fragment length polymorphism; T-scores
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