Development of the Room Temperature Protocol Based on Room Temperature Ionic Liquids and Surfactant Ionic Liquids for the Synthesis of Derivatives of 2-Amino-Thiazoles and Thermo- Physical Analysis of the Synthesized Derivatives Using TGA-DSC

Aims: To develop an efficient protocol, which involves an exploration of the catalytic potential of both the room temperature and surfactant ionic liquids towards the synthesis of biologically important derivatives of 2-aminothiazole. Objective: Specific heat capacity data as a function of temperature for the synthesized 2- aminothiazole derivatives has been advanced by exploring their thermal profiles. Methods: The thermal gravimetry analysis and differential scanning calorimetry techniques are used systematically. Results: The present strategy could prove to be useful for researchers working in the field of surfactants and surfactant-based ionic liquids towards their exploration in organic synthesis. In addition to that, the effect of electronic parameters on the melting temperature of the corresponding 2-aminothiazole has been demonstrated with the help of thermal analysis. Specific heat capacity data as a function of temperature for the synthesized 2- aminothiazole derivatives has also been reported. Conclusion: Melting behavior of the synthesized 2-aminothiazole derivatives is to be described on the basis of electronic effects with the help of thermal analysis. Additionally, the specific heat capacity data can be helpful for the chemists, those engaged in chemical modelling as well as docking studies. Furthermore, the data also helps to determine valuable thermodynamic parameters such as entropy and enthalpy.