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- ISSN: 1389-2010
- E-ISSN: 1873-4316
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RNAi Screening for Therapeutic Targets in Human Malignancies
- Source: Current Pharmaceutical Biotechnology, Volume 8, Issue 6, Dec 2007, p. 337 - 343
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- 01 Dec 2007
Abstract
The advent of RNA interference (RNAi) based library screening approaches has sparked a surge in loss-of-function genetic screens. Several recent screens have aimed to identify novel regulators of cancer-related phenotypes. These employ various tumor cell types to model malignant cell functions and use different RNAi effector library approaches to reveal a cache of novel tumor regulators. This review surveys recent RNAi screens conducted in transformed human cells.
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