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2000
Volume 7, Issue 1
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases have been implicated in a number of connective tissue pathologies including Ehlers-Danlos syndrome type VII C, Weill-Marchesani syndrome, encephalomyelitis, and arthritis. These proteinases therefore represent potential therapeutic targets for the treatment of such conditions. The synthesis and activity of ADAMTS proteinases is regulated at multiple levels: transcription, RNA splicing, translation, proteolytic processing, cofactor stimulation and inhibition, each of which represents a possible point of therapeutic intervention. Recent research suggests that, in addition to the direct inhibition of ADAMTS proteinases with low molecular weight non-peptidic inhibitors, targeting the transcription and protein processing of these enzymes could be effective therapeutic approaches.

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/content/journals/cpb/10.2174/138920106775789656
2006-02-01
2025-07-06
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  • Article Type:
    Research Article
Keyword(s): ADAMTS; metalloproteinase; regulation; therapy
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