The Impact of Elevated Progesterone on the Initiation of an Artificially Prepared Frozen Embryo Transfer Cycle: A Case Series

Background: The role of elevated baseline progesterone (P) levels in outcomes of frozen embryo transfers (FET) performed in an artificial cycle has not been investigated yet. Objective: To evaluate the role of elevated P in artificial FET. Method: Case series study of 12 patients with high P levels undergoing artificial FET recruited during a 6-month period in a tertiary referral center. Results: The clinical pregnancy rate per transfer was 4/12 (33.3%). The biochemical pregnancy rate was 6/12 (50.0%). Conclusion: Elevated levels of P do not seem to have a negative impact on reproductive outcome, and may even be associated with high clinical and biochemical pregnancy rates. Further prospective or large retrospective studies are required to examine the clinical importance of our findings in a larger population.