Recent Developments of Three-Dimensional Paper-Based Electrochemical Devices for Cancer Cell Detection and Anticancer Drug Screening

Cancer, as the most serious threat to human health, poses millions of deaths in the world each year. In vitro cancer cell and biomarker detection is of great importance for early cancer diagnosis and therapy, which needs highly sensitive, selective and quantitative diagnosis platforms. Threedimensional paper-based electrochemical devices (3D-PEDs) have attracted considerable interest in biomedical fields in recent years based on their simplicity, low cost, portability, high sensitivity and selectivity. Recently, since 3D-PEDs can particularly provide in vitro 3D structures to mimic the native 3D cell microenvironment, they have been used to detect cancer cells and monitor their responses to anticancer drug treatment in terms of cancer cell concentration, cancer cell apoptosis and cancer biomarkers. This review discusses the recent development of 3D-PEDs and their applications in detection of cancer cells and anticancer drug screening.