Skip to content
2000
Volume 15, Issue 6
  • ISSN: 1389-2010
  • E-ISSN: 1873-4316

Abstract

Systemic sclerosis (scleroderma) is a heterogeneous autoimmune disorder characterized by collagen overproduction that leads to cutaneous and internal organs sclerosis and pulmonary arterial hypertension. SSc has high morbidity and mortality. SSc pathogenesis is uncertain. At present most therapies of SSc are symptomatic. Effective therapeutic approaches are lacking. Accompanying a growing understanding of SSc pathogenesis, various key mediators are being evaluated as the therapeutic targets. This review described the effects of these key mediators in SSc.

Loading

Article metrics loading...

/content/journals/cpb/10.2174/138920101506140910150749
2014-06-01
2025-07-04
Loading full text...

Full text loading...

/content/journals/cpb/10.2174/138920101506140910150749
Loading

  • Article Type:
    Research Article
Keyword(s): Antibodies; biologics; fibrosis; pathogenesis; systemic sclerosis
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test