Skip to content
2000
Volume 12, Issue 6
  • ISSN: 1871-5273
  • E-ISSN: 1996-3181

Abstract

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

Loading

Article metrics loading...

/content/journals/cnsnddt/10.2174/18715273113126660168
2013-09-01
2025-07-15
Loading full text...

Full text loading...

/content/journals/cnsnddt/10.2174/18715273113126660168
Loading

  • Article Type:
    Research Article
Keyword(s): chemokine; cytokine; Nerve injury; neuropathy; plasticity; purine receptor; spinal cord injury
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test