Skip to content
2000
Volume 21, Issue 11
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Dystonia, the third most common movement disorder, refers to a heterogeneous group of neurological diseases characterized by involuntary, sustained or intermittent muscle contractions resulting in repetitive twisting movements and abnormal postures. In the last few years, several studies on animal models helped expand our knowledge of the molecular mechanisms underlying dystonia. These findings have reinforced the notion that the synaptic alterations found mainly in the basal ganglia and cerebellum, including the abnormal neurotransmitters signalling, receptor trafficking and synaptic plasticity, are a common hallmark of different forms of dystonia. In this review, we focus on the major contribution provided by rodent models of DYT-, DYT-, DYT-, DYT/ PARK-, DYT/PARK- and DYT- dystonia, which reveal that an abnormal motor network and synaptic dysfunction represent key elements in the pathophysiology of dystonia.

Loading

Article metrics loading...

/content/journals/cn/10.2174/1570159X21666230718100156
2023-11-01
2024-12-24
Loading full text...

Full text loading...

/content/journals/cn/10.2174/1570159X21666230718100156
Loading

  • Article Type:
    Review Article
Keyword(s): cerebellum; dystonia; movement disorders; rodent models; striatum; Synaptic dysfunction
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test