Skip to content
2000
Volume 21, Issue 11
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Autism spectrum disorder (ASD) is a cluster of heterogeneous neurodevelopmental conditions with atypical social communication and repetitive sensory-motor behaviors. The formation of new neurons from neural precursors in the hippocampus has been unequivocally demonstrated in the dentate gyrus of rodents and non-human primates. Accumulating evidence sheds light on how the deficits in the hippocampal neurogenesis may underlie some of the abnormal behavioral phenotypes in ASD. In this review, we describe the current evidence concerning pre-clinical and clinical studies supporting the significant role of hippocampal neurogenesis in ASD pathogenesis, discuss the possibility of improving hippocampal neurogenesis as a new strategy for treating ASD, and highlight the prospect of emerging pro128;neurogenic therapies for ASD.

Loading

Article metrics loading...

/content/journals/cn/10.2174/1570159X21666221220155455
2023-11-01
2024-12-24
Loading full text...

Full text loading...

/content/journals/cn/10.2174/1570159X21666221220155455
Loading

  • Article Type:
    Review Article
Keyword(s): Autism; dentate gyrus; hippocampus; neurodevelopment; neurogenesis; stem cell
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test