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Volume 13, Issue 6
  • ISSN: 1570-159X
  • E-ISSN: 1875-6190

Abstract

Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits glutamatergic transmission (i.e. AMPA/kainate receptors). Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine reinforcement. Therefore, TPM could be used in the management of cocaine dependence.

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/content/journals/cn/10.2174/1570159X13666150729222643
2015-12-01
2025-07-05

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  • Article Type:     Research Article
Keyword(s): Cocaine dependence; gamma-aminobutyric acid neurotransmission; glutamatergic neurotransmission; topiramate

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