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image of Advances and Challenges in Traumatic Brain Injury from a Forensic Perspective

Abstract

Traumatic brain injury (TBI) is one of the leading causes of death and disability. Animal and clinical studies of TBI have greatly changed the clinical practice of TBI with the development and application of new technologies. However, with the development of forensic science, legal issues related to TBI continue to emerge, and it is still far from satisfactory that the practical application of relevant research findings as legal evidence in court practice. This review discusses an overview of the latest progress of TBI through neuropathological changes, secondary injury mechanisms, postmortem neuroimaging, cognitive, emotional, and behavioral impairments, biomarkers, and the effects of toxins and drugs on brain injury from a forensic perspective. Meanwhile, we highlight the interpretability and limitations of findings on TBI in legal proceedings are ongoing challenges.

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2025-02-26
2025-03-27

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References

  1. Menon D.K. Schwab K. Wright D.W. Maas A.I. Position statement: definition of traumatic brain injury. Arch. Phys. Med. Rehabil. 2010 91 11 1637 1640 10.1016/j.apmr.2010.05.017 21044706
    [Google Scholar]
  2. Feigin V.L. Theadom A. Barker-Collo S. Starkey N.J. McPherson K. Kahan M. Dowell A. Brown P. Parag V. Kydd R. Jones K. Jones A. Ameratunga S. Incidence of traumatic brain injury in New Zealand: a population-based study. Lancet Neurol. 2013 12 1 53 64 10.1016/S1474‑4422(12)70262‑4 23177532
    [Google Scholar]
  3. Faul M. Wald M.M. Rutland-Brown W. Sullivent E.E. Sattin R.W. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing theBrain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. J. Trauma 2007 63 6 1271 1278 10.1097/TA.0b013e3181493080 18212649
    [Google Scholar]
  4. Dewan M.C. Rattani A. Gupta S. Baticulon R.E. Hung Y.C. Punchak M. Agrawal A. Adeleye A.O. Shrime M.G. Rubiano A.M. Rosenfeld J.V. Park K.B. Estimating the global incidence of traumatic brain injury. J. Neurosurg. 2019 130 4 1080 1097 10.3171/2017.10.JNS17352 29701556
    [Google Scholar]
  5. Rubiano A.M. Carney N. Chesnut R. Puyana J.C. Global neurotrauma research challenges and opportunities. Nature 2015 527 7578 S193 S197 10.1038/nature16035 26580327
    [Google Scholar]
  6. Roozenbeek B. Maas A.I.R. Menon D.K. Changing patterns in the epidemiology of traumatic brain injury. Nat. Rev. Neurol. 2013 9 4 231 236 10.1038/nrneurol.2013.22 23443846
    [Google Scholar]
  7. Jiang J.Y. Gao G.Y. Feng J.F. Mao Q. Chen L.G. Yang X.F. Liu J.F. Wang Y.H. Qiu B.H. Huang X.J. Traumatic brain injury in China. Lancet Neurol. 2019 18 3 286 295 10.1016/S1474‑4422(18)30469‑1 30784557
    [Google Scholar]
  8. de Ramirez S.S. Hyder A.A. Herbert H.K. Stevens K. Unintentional injuries: magnitude, prevention, and control. Annu. Rev. Public Health 2012 33 1 175 191 10.1146/annurev‑publhealth‑031811‑124558 22224893
    [Google Scholar]
  9. Pearn M.L. Niesman I.R. Egawa J. Sawada A. Almenar-Queralt A. Shah S.B. Duckworth J.L. Head B.P. Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics. Cell. Mol. Neurobiol. 2017 37 4 571 585 10.1007/s10571‑016‑0400‑1 27383839
    [Google Scholar]
  10. Vella M.A. Crandall M.L. Patel M.B. Acute management of traumatic brain injury. Surg. Clin. North Am. 2017 97 5 1015 1030 10.1016/j.suc.2017.06.003 28958355
    [Google Scholar]
  11. Spaite D.W. Bobrow B.J. Keim S.M. Association of statewide implementation of the prehospital traumatic brain injury treatment guidelines with patient survival following traumatic brain injury: The excellence in prehospital injury care (EPIC) study. JAMA Surg. 2019 154 e191152
    [Google Scholar]
  12. McMullan J.T. Ventura A. LeBlanc D.P. Emergency medical services traumatic brain injury protocols do not reflect brain trauma foundation guidelines. Prehosp. Emerg. Care 2021 25 3 347 350 10.1080/10903127.2020.1770388 32412355
    [Google Scholar]
  13. van Essen T.A. den Boogert H.F. Cnossen M.C. de Ruiter G.C.W. Haitsma I. Polinder S. Steyerberg E.W. Menon D. Maas A.I.R. Lingsma H.F. Peul W.C. Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study. Acta Neurochir. (Wien) 2019 161 3 435 449 10.1007/s00701‑018‑3761‑z 30569224
    [Google Scholar]
  14. Cook A.M. Morgan Jones G. Hawryluk G.W.J. Mailloux P. McLaughlin D. Papangelou A. Samuel S. Tokumaru S. Venkatasubramanian C. Zacko C. Zimmermann L.L. Hirsch K. Shutter L. Guidelines for the acute treatment of cerebral edema in neurocritical care patients. Neurocrit. Care 2020 32 3 647 666 10.1007/s12028‑020‑00959‑7 32227294
    [Google Scholar]
  15. Huie J.R. Mondello S. Lindsell C.J. Antiga L. Yuh E.L. Zanier E.R. Masson S. Rosario B.L. Ferguson A.R. Adeoye O. Badjatia N. Boase K. Bodien Y. Bullock M.R. Chesnut R. Corrigan J.D. Crawford K. Diaz-Arrastia R. Dikmen S. Duhaime A-C. Ellenbogen R. Feeser V.R. Foreman B. Gardner R. Gaudette E. Giacino J. Goldman D. Gonzalez L. Gopinath S. Gullapalli R. Hemphill J.C. Hotz G. Jain S. Korley F. Kramer J. Kreitzer N. Levin H. Machamer J. Madden C. Manley G.T. Martin A. McAllister T. McCrea M. Merchant R. Mukherjee P. Nelson L. Ngwenya L.B. Noel F. Okonkwo D. Perl D. Puccio A. Rabinowitz M. Robertson C. Rosand J. Sander A. Schnyer D. Seabury S. Stein M. Taylor S. Temkin N. Toga A. Valadka A. Vassar M. Vespa P. Wang K. Yue J.K. Zafonte R. Ackerlund C. Adams H. Agnoletti V. Allanson J. Amrein K. Andaluz N. Andelic N. Andreassen L. Anke A. Antun A. Antoni A. Ardon H. Auslands K. Azouvi P. Luisa Azzolini M. Baciu C. Badenes R. Bartels R. Barzó P. Bauerfeind U. Beauvais R. Beer R. Belda F.J. Bellander B.M. Belli A. Bellier R. Benali H. Benard T. Berardino M. Beretta L. Beynon C. Bilotta F. Binder H. Biqiri E. Blaabjerg M. Boogert H. Bragge P. Brazinova A. Brinck V. Brooker J. Brorsson C. Buki A. Bullinger M. Cabeleira M. Calappi E. Calvi M.R. Cameron P. Carbayo L.G. Carbonara M. Carise E. Carpenter K. Castaño León A.M. Causin F. Chevallard G. Chieregato A. Citerio G. Cnossen M. Coburn M. Coles J. Coles-Kemp L. Collett J. Cooper J.D. Correia M. Covic A. Curry N. Czeiter E. Czosnyka M. Fizelier C.D. Damas F. Damas P. Dawes H. De Keyser V. Corte F.D. Depreitere B. de Ruiter G.C.W. Dilvesi D. Ding S. Dippel D. Dixit A. Donoghue E. Dreier J. Dulière G.L. Engemann H. Ercole A. Esser P. Ezer E. Fabricius M. Feigin V.L. Feng J. Foks K. Fossi F. Francony G. Freo U. Frisvold S. Furmanov A. Gagliardo P. Galanaud D. Gantner D. Gao G. Geleijns K. George P. Ghuysen A. Giga L. Giraud B. Glocker B. Golubovic J. Gomez P.A. Gravesteijn B. Grossi F. Gruen R.L. Gupta D. Haagsma J.A. Håberg A.K. Jacobs B. Haitsma I. Hartings J.A. Helbok R. Helseth E. Hertle D. Hoedemaekers A. Hoefer S. Horton L. Huijben J. Hutchinson P.J. Jankowski S. Jarrett M. Jelaca B. Jiang J. Jones K. Kamnitsas K. Karan M. Katila A. Kaukonen M. Kerforne T. Kivisaari R. Kolias A.G. Kolumbán B. Kompanje E. Kolundzija K. Kondziella D. Koskinen L.O. Kovács N. Lagares A. Lanyon L. Laureys S. Lecky F. Ledig C. Lefering R. Legrand V. Lei J. Levi L. Lightfoot R. Lingsma H. Loeckx D. Lozano A. Maas A.I.R. MacDonald S. Maegele M. Marek M. Major S. Manara A. Manley G. Martin D. Martin L.F. Martino C. Maréchal H. Maruenda A. Masala A. Mattern J. McFadyen C. McMahon C. Melegh B. Menon D. Menovsky T. Kossmann C.M. Mulazzi D. Mühlan H. Muraleedharan V. Murray L. Nair N. Negru A. Nelson D. Newcombe V. Nieboer D. Noirhomme Q. Nyirádi J. Oddo M. Oldenbeuving A. Oresic M. Ortolano F. Palotie A. Parizel P.M. Patruno A. Payen J.F. Perera N. Perlbarg V. Persona P. Peul W. Piippo-Karjalainen A. Pili F.S. Pirinen M. Ples H. Poca M.A. Polinder S. Pomposo I. Posti J. Puybasset L. Radoi A. Ragauskas A. Raj R. Rambadagalla M. Real R. Rehorčíková V. Rhodes J. Ripatti S. Rocka S. Roe C. Roise O. Roks G. Rosand J. Rosenfeld J. Rosenlund C. Rosenthal G. Rossaint R. Rossi S. Rueckert D. Rusnák M. Sacchi M. Sahakian B. Sahuquillo J. Sakowitz O. Sala F. Porras R.S. Sandor J. Santos E. Sasu L. Savo D. Schäffer N. Schipper I. Schlößer B. Schmidt S. Schoechl H. Schoonman G. Schou R.F. Schwendenwein E. Schöll M. Sewalt C. Sir Ö. Skandsen T. Smakman L. Smeets D. Smielewski P. Sorinola A. Stamatakis E. Stanworth S. Steinbüchel N. Stevanovic A. Stevens R. Stewart W. Steyerberg E.W. Stocchetti N. Sundström N. Synnot A. Taccone F.S. Takala R. Tamás V. Tanskanen P. Taylor M.S. Te Ao B. Tenovuo O. Telgmann R. Teodorani G. Theadom A. Thomas M. Tibboel D. Tolias C. Tshibanda J.F.L. Trapani T. Tudora C.M. Vajkoczy P. Vallance S. Valeinis E. der Steen G.V. der Jagt M. de Naalt J.V. van Dijck J.T.J.M. van Essen T.A. Hecke W.V. Heugten C. Praag D.V. Vyvere T.V. Waesberghe J.V. Vanhaudenhuyse A. Vargiolu A. Vega E. Velt K. Verheyden J. Vespa P.M. Vik A. Vilcinis R. Vizzino G. Lankamp C.V. Volovici V. Voormolen D. Vulekovic P. Vámos Z. Wade D. Wang K.K.W. Wang L. Wessels L. Wiegers E. Wildschut E. Williams G. Wilson L. Winkler M.K.L. Wolf S. Ylén P. Younsi A. Zaaroor M. Zeiler F. Zhihui Y. Ziverte A. Zumbo F. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations. J. Neurotrauma 2021 38 18 2514 2529 10.1089/neu.2019.6762 32046588
    [Google Scholar]
  16. Citerio G. Prisco L. Oddo M. Meyfroidt G. Helbok R. Stocchetti N. Taccone F. Vincent J.L. Robba C. Elli F. Sala E. Vargiolu A. Lingsma H. International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol. BMJ Open 2019 9 4 e026552 10.1136/bmjopen‑2018‑026552 31005932
    [Google Scholar]
  17. Bazarian J.J. Biberthaler P. Welch R.D. Lewis L.M. Barzo P. Bogner-Flatz V. Gunnar Brolinson P. Büki A. Chen J.Y. Christenson R.H. Hack D. Huff J.S. Johar S. Jordan J.D. Leidel B.A. Lindner T. Ludington E. Okonkwo D.O. Ornato J. Peacock W.F. Schmidt K. Tyndall J.A. Vossough A. Jagoda A.S. Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicentre observational study. Lancet Neurol. 2018 17 9 782 789 10.1016/S1474‑4422(18)30231‑X 30054151
    [Google Scholar]
  18. Lagerstedt L. Azurmendi L. Tenovuo O. Katila A.J. Takala R.S.K. Blennow K. Newcombe V.F.J. Maanpää H.R. Tallus J. Hossain I. Gils M. Menon D.K. Hutchinson P.J. Zetterberg H. Posti J.P. Sanchez J.C. Interleukin 10 and heart fatty acid-binding protein as early outcome predictors in patients with traumatic brain injury. Front. Neurol. 2020 11 376 10.3389/fneur.2020.00376 32581990
    [Google Scholar]
  19. Papa L. Brophy G.M. Welch R.D. Lewis L.M. Braga C.F. Tan C.N. Ameli N.J. Lopez M.A. Haeussler C.A. Mendez Giordano D.I. Silvestri S. Giordano P. Weber K.D. Hill-Pryor C. Hack D.C. Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large cohort of trauma patients with and without mild traumatic brain injury. JAMA Neurol. 2016 73 5 551 560 10.1001/jamaneurol.2016.0039 27018834
    [Google Scholar]
  20. Rubenstein R. Chang B. Yue J. Comparing plasma phospho tau, total tau, and phospho tau-total tau ratio as acute and chronic traumatic brain injury biomarkers. JAMA Neurol. 2017 74 9 1063 1072 10.1001/jamaneurol.2017.0655
    [Google Scholar]
  21. Ghaith H.S. Nawar A.A. Gabra M.D. Abdelrahman M.E. Nafady M.H. Bahbah E.I. Ebada M.A. Ashraf G.M. Negida A. Barreto G.E. A Literature Review of Traumatic Brain Injury Biomarkers. Mol. Neurobiol. 2022 59 7 4141 4158 10.1007/s12035‑022‑02822‑6 35499796
    [Google Scholar]
  22. Zheng L. Pang Q. Xu H. Guo H. Liu R. Wang T. The neurobiological links between stress and traumatic brain injury: A review of research to date. Int. J. Mol. Sci. 2022 23 17 9519 10.3390/ijms23179519 36076917
    [Google Scholar]
  23. Bertozzi G. Maglietta F. Sessa F. Scoto E. Cipolloni L. Di Mizio G. Salerno M. Pomara C. Traumatic Brain Injury: A Forensic Approach: A Literature Review. Curr. Neuropharmacol. 2020 18 6 538 550 10.2174/1570159X17666191101123145 31686630
    [Google Scholar]
  24. Finnie J.W. Forensic Pathology of Traumatic Brain Injury. Vet. Pathol. 2016 53 5 962 978 10.1177/0300985815612155 26578643
    [Google Scholar]
  25. La Russa R. Maiese A. Cipolloni L. Di Fazio N. Delogu G. De Matteis A. Del Fante Z. Manetti F. Frati P. Fineschi V. Diagnostic assessment of traumatic brain injury by vacuum extraction in newborns: overview on forensic perspectives and proposal of operating procedures. Front. Biosci. (Landmark Ed.) 2022 27 3 079 10.31083/j.fbl2703079 35345311
    [Google Scholar]
  26. Wang Y. Chen Q. Dang X. Lu W. Zhang X. Yan H. Niu S. Yan X. Yan J. A bibliometric analysis on traumatic brain injury in forensic medicine of a half-century (1972–2021). Front. Neurol. 2023 14 913855 10.3389/fneur.2023.913855 36816552
    [Google Scholar]
  27. Chen Q. Chen X. Xu L. Zhang R. Li Z. Yue X. Qiao D. Traumatic axonal injury: neuropathological features, postmortem diagnostic methods, and strategies. Forensic Sci. Med. Pathol. 2022 18 4 530 544 10.1007/s12024‑022‑00522‑0 36117238
    [Google Scholar]
  28. Castellani R.J. Smith M. Bailey K. Perry G. deJong J.L. Neuropathology in Consecutive Forensic Consultation Cases with a History of Remote Traumatic Brain Injury. J. Alzheimers Dis. 2019 72 3 683 691 10.3233/JAD‑190782 31609691
    [Google Scholar]
  29. Romero Tirado M.Á. Blanco Pampin J.M. Gallego Gómez R. Dating of Traumatic Brain Injury in Forensic Cases Using Immunohistochemical Markers (I). Am. J. Forensic Med. Pathol. 2018 39 3 201 207 10.1097/PAF.0000000000000412 29901458
    [Google Scholar]
  30. Koludarova E.M. Sudebno-meditsinskie kriterii diagnostiki davnosti diffuznogo aksonal’nogo povrezhdeniya mozga pri cherepno-mozgovoi travme. Sud. Med. Ekspert. 2021 64 3 17 20 10.17116/sudmed20216403117 34013689
    [Google Scholar]
  31. Kenzie E.S. Parks E.L. Bigler E.D. Wright D.W. Lim M.M. Chesnutt J.C. Hawryluk G.W.J. Gordon W. Wakeland W. The dynamics of concussion: mapping pathophysiology, persistence, and recovery with causal-loop diagramming. Front. Neurol. 2018 9 203 10.3389/fneur.2018.00203 29670568
    [Google Scholar]
  32. Weaver S.M. Portelli J.N. Chau A. Cristofori I. Moretti L. Grafman J. Genetic polymorphisms and traumatic brain injury: the contribution of individual differences to recovery. Brain Imaging Behav. 2014 8 3 420 434 10.1007/s11682‑012‑9197‑9 22878895
    [Google Scholar]
  33. Waters R.J. Murray G.D. Teasdale G.M. Stewart J. Day I. Lee R.J. Nicoll J.A.R. Cytokine gene polymorphisms and outcome after traumatic brain injury. J. Neurotrauma 2013 30 20 1710 1716 10.1089/neu.2012.2792 23768161
    [Google Scholar]
  34. Blennow K. Brody D.L. Kochanek P.M. Levin H. McKee A. Ribbers G.M. Yaffe K. Zetterberg H. Traumatic brain injuries. Nat. Rev. Dis. Primers 2016 2 1 16084 10.1038/nrdp.2016.84 27853132
    [Google Scholar]
  35. Haarbauer-Krupa J. Pugh M.J. Prager E.M. Harmon N. Wolfe J. Yaffe K. Epidemiology of Chronic Effects of Traumatic Brain Injury. J. Neurotrauma 2021 38 23 3235 3247 10.1089/neu.2021.0062 33947273
    [Google Scholar]
  36. Capizzi A. Woo J. Verduzco-Gutierrez M. Traumatic Brain Injury. Med. Clin. North Am. 2020 104 2 213 238 10.1016/j.mcna.2019.11.001 32035565
    [Google Scholar]
  37. Rule G. Bocchieri R. Burns J. Young L. Biophysical mechanisms of traumatic brain injuries. Semin. Neurol. 2015 35 1 005 011 10.1055/s‑0035‑1544242 25714862
    [Google Scholar]
  38. Nakagawa A. Manley G.T. Gean A.D. Ohtani K. Armonda R. Tsukamoto A. Yamamoto H. Takayama K. Tominaga T. Mechanisms of primary blast-induced traumatic brain injury: insights from shock-wave research. J. Neurotrauma 2011 28 6 1101 1119 10.1089/neu.2010.1442 21332411
    [Google Scholar]
  39. Hoogenboom W.S. Branch C.A. Lipton M.L. Animal models of closed-skull, repetitive mild traumatic brain injury. Pharmacol. Ther. 2019 198 109 122 10.1016/j.pharmthera.2019.02.016 30822463
    [Google Scholar]
  40. Khellaf A. Khan D.Z. Helmy A. Recent advances in traumatic brain injury. J. Neurol. 2019 266 11 2878 2889 10.1007/s00415‑019‑09541‑4 31563989
    [Google Scholar]
  41. Chamoun R. Suki D. Gopinath S.P. Goodman J.C. Robertson C. Role of extracellular glutamate measured by cerebral microdialysis in severe traumatic brain injury. J. Neurosurg. 2010 113 3 564 570 10.3171/2009.12.JNS09689 20113156
    [Google Scholar]
  42. Palmieri M. Frati A. Santoro A. Frati P. Fineschi V. Pesce A. Diffuse Axonal Injury: Clinical Prognostic Factors, Molecular Experimental Models and the Impact of the Trauma Related Oxidative Stress. An Extensive Review Concerning Milestones and Advances. Int. J. Mol. Sci. 2021 22 19 10865 10.3390/ijms221910865 34639206
    [Google Scholar]
  43. Smith D.H. Meaney D.F. Shull W.H. Diffuse axonal injury in head trauma. J. Head Trauma Rehabil. 2003 18 4 307 316 10.1097/00001199‑200307000‑00003 16222127
    [Google Scholar]
  44. Maxwell W.L. Povlishock J.T. Graham D.L. A mechanistic analysis of nondisruptive axonal injury: a review. J. Neurotrauma 1997 14 7 419 440 10.1089/neu.1997.14.419 9257661
    [Google Scholar]
  45. Shaw G. Yang C. Ellis R. Anderson K. Parker Mickle J. Scheff S. Pike B. Anderson D.K. Howland D.R. Hyperphosphorylated neurofilament NF-H is a serum biomarker of axonal injury. Biochem. Biophys. Res. Commun. 2005 336 4 1268 1277 10.1016/j.bbrc.2005.08.252 16176808
    [Google Scholar]
  46. McGinn M.J. Povlishock J.T. Pathophysiology of traumatic brain injury. Neurosurg. Clin. N. Am. 2016 27 4 397 407 10.1016/j.nec.2016.06.002 27637392
    [Google Scholar]
  47. Barkhoudarian G. Hovda D.A. Giza C.C. The molecular pathophysiology of concussive brain injury—an update. Phys. Med. Rehabil. Clin. N. Am. 2016 27 2 373 393 10.1016/j.pmr.2016.01.003 27154851
    [Google Scholar]
  48. Salehi A. Zhang J.H. Obenaus A. Response of the cerebral vasculature following traumatic brain injury. J. Cereb. Blood Flow Metab. 2017 37 7 2320 2339 10.1177/0271678X17701460 28378621
    [Google Scholar]
  49. Ziebell J.M. Adelson P.D. Lifshitz J. Microglia: dismantling and rebuilding circuits after acute neurological injury. Metab. Brain Dis. 2015 30 2 393 400 10.1007/s11011‑014‑9539‑y 24733573
    [Google Scholar]
  50. Kumar A. Loane D.J. Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention. Brain Behav. Immun. 2012 26 8 1191 1201 10.1016/j.bbi.2012.06.008 22728326
    [Google Scholar]
  51. Ladak A.A. Enam S.A. Ibrahim M.T. A Review of the Molecular Mechanisms of Traumatic Brain Injury. World Neurosurg. 2019 131 126 132 10.1016/j.wneu.2019.07.039 31301445
    [Google Scholar]
  52. Zhou Y. Fan R. Botchway B.O.A. Zhang Y. Liu X. Infliximab Can Improve Traumatic Brain Injury by Suppressing the Tumor Necrosis Factor Alpha Pathway. Mol. Neurobiol. 2021 58 6 2803 2811 10.1007/s12035‑021‑02293‑1 33501626
    [Google Scholar]
  53. Hunt R.F. Boychuk J.A. Smith B.N. Neural circuit mechanisms of post–traumatic epilepsy. Front. Cell. Neurosci. 2013 7 89 10.3389/fncel.2013.00089 23785313
    [Google Scholar]
  54. Delic V. Beck K.D. Pang K.C.H. Citron B.A. Biological links between traumatic brain injury and Parkinson’s disease. Acta Neuropathol. Commun. 2020 8 1 45 10.1186/s40478‑020‑00924‑7 32264976
    [Google Scholar]
  55. Brett B.L. Gardner R.C. Godbout J. Dams-O’Connor K. Keene C.D. Traumatic Brain Injury and Risk of Neurodegenerative Disorder. Biol. Psychiatry 2022 91 5 498 507 10.1016/j.biopsych.2021.05.025 34364650
    [Google Scholar]
  56. Ramos-Cejudo J. Wisniewski T. Marmar C. Zetterberg H. Blennow K. de Leon M.J. Fossati S. Traumatic Brain Injury and Alzheimer’s Disease: The Cerebrovascular Link. EBioMedicine 2018 28 21 30 10.1016/j.ebiom.2018.01.021 29396300
    [Google Scholar]
  57. Smirnov D. Galasko D. Dynamics of neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2022 21 4 297 298 10.1016/S1474‑4422(22)00087‑4 35305329
    [Google Scholar]
  58. Heneka M.T. Carson M.J. Khoury J.E. Landreth G.E. Brosseron F. Feinstein D.L. Jacobs A.H. Wyss-Coray T. Vitorica J. Ransohoff R.M. Herrup K. Frautschy S.A. Finsen B. Brown G.C. Verkhratsky A. Yamanaka K. Koistinaho J. Latz E. Halle A. Petzold G.C. Town T. Morgan D. Shinohara M.L. Perry V.H. Holmes C. Bazan N.G. Brooks D.J. Hunot S. Joseph B. Deigendesch N. Garaschuk O. Boddeke E. Dinarello C.A. Breitner J.C. Cole G.M. Golenbock D.T. Kummer M.P. Neuroinflammation in Alzheimer’s disease. Lancet Neurol. 2015 14 4 388 405 10.1016/S1474‑4422(15)70016‑5 25792098
    [Google Scholar]
  59. Bai R. Guo J. Ye X.Y. Xie Y. Xie T. Oxidative stress: The core pathogenesis and mechanism of Alzheimer’s disease. Ageing Res. Rev. 2022 77 101619 10.1016/j.arr.2022.101619 35395415
    [Google Scholar]
  60. Ramírez B.G. Blázquez C. del Pulgar T.G. Guzmán M. de Ceballos M.L. Prevention of Alzheimer’s disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 2005 25 8 1904 1913 10.1523/JNEUROSCI.4540‑04.2005 15728830
    [Google Scholar]
  61. Sastre M. Dewachter I. Landreth G.E. Willson T.M. Klockgether T. van Leuven F. Heneka M.T. Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. J. Neurosci. 2003 23 30 9796 9804 10.1523/JNEUROSCI.23‑30‑09796.2003 14586007
    [Google Scholar]
  62. Duman R.S. Girgenti M.J. Molecular and cellular studies of PTSD: Postmortem transcriptome analysis and novel therapeutic targets. J. Neurosci. Res. 2019 97 3 292 299 10.1002/jnr.24306 30136735
    [Google Scholar]
  63. Compean E. Hamner M. Posttraumatic stress disorder with secondary psychotic features (PTSD-SP): Diagnostic and treatment challenges. Prog Neuropsychopharmacol Biol Psychiatry. 2019 88 265 275 10.1016/j.pnpbp.2018.08.001
    [Google Scholar]
  64. Heim C. Newport D.J. Mletzko T. Miller A.H. Nemeroff C.B. The link between childhood trauma and depression: Insights from HPA axis studies in humans. Psychoneuroendocrinology 2008 33 6 693 710 10.1016/j.psyneuen.2008.03.008 18602762
    [Google Scholar]
  65. Weis C.N. Webb E.K. deRoon-Cassini T.A. Larson C.L. Emotion Dysregulation Following Trauma: Shared Neurocircuitry of Traumatic Brain Injury and Trauma-Related Psychiatric Disorders. Biol. Psychiatry 2022 91 5 470 477 10.1016/j.biopsych.2021.07.023 34561028
    [Google Scholar]
  66. Howlett J.R. Nelson L.D. Stein M.B. Mental Health Consequences of Traumatic Brain Injury. Biol. Psychiatry 2022 91 5 413 420 10.1016/j.biopsych.2021.09.024 34893317
    [Google Scholar]
  67. Chen Y.F. Zhao H. Post-traumatic stress disorder: Relationship to traumatic brain injury and approach to forensic psychiatry evaluation. J. Forensic Sci. Med. 2019 5 1 33 39 10.4103/jfsm.jfsm_46_18
    [Google Scholar]
  68. Stein M.B. Kessler R.C. Heeringa S.G. Jain S. Campbell-Sills L. Colpe L.J. Fullerton C.S. Nock M.K. Sampson N.A. Schoenbaum M. Sun X. Thomas M.L. Ursano R.J. Prospective longitudinal evaluation of the effect of deployment-acquired traumatic brain injury on posttraumatic stress and related disorders: results from the Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS). Am. J. Psychiatry 2015 172 11 1101 1111 10.1176/appi.ajp.2015.14121572 26337036
    [Google Scholar]
  69. Bonanno G.A. Mancini A.D. Horton J.L. Powell T.M. LeardMann C.A. Boyko E.J. Wells T.S. Hooper T.I. Gackstetter G.D. Smith T.C. Trajectories of trauma symptoms and resilience in deployed US military service members: Prospective cohort study. Br. J. Psychiatry 2012 200 4 317 323 10.1192/bjp.bp.111.096552 22361018
    [Google Scholar]
  70. Alway Y. Gould K.R. McKay A. Johnston L. Ponsford J. The Evolution of Post-Traumatic Stress Disorder following Moderate-to-Severe Traumatic Brain Injury. J. Neurotrauma 2016 33 9 825 831 10.1089/neu.2015.3992 26176500
    [Google Scholar]
  71. Fitzgerald J.M. DiGangi J.A. Phan K.L. Functional Neuroanatomy of Emotion and Its Regulation in PTSD. Harv. Rev. Psychiatry 2018 26 3 116 128 10.1097/HRP.0000000000000185 29734226
    [Google Scholar]
  72. Hoffman A.N. Taylor A.N. Stress reactivity after traumatic brain injury: implications for comorbid post-traumatic stress disorder. Behav. Pharmacol. 2019 30 2 & 3 special issue 115 121 10.1097/FBP.0000000000000461
    [Google Scholar]
  73. Etkin A. Büchel C. Gross J.J. The neural bases of emotion regulation. Nat. Rev. Neurosci. 2015 16 11 693 700 10.1038/nrn4044 26481098
    [Google Scholar]
  74. Rice T.R. Commentary: The Neural Bases of Emotion Regulation. Front. Psychol. 2016 7 476 10.3389/fpsyg.2016.00476 27065935
    [Google Scholar]
  75. Martin R.E. Ochsner K.N. The neuroscience of emotion regulation development: implications for education. Curr. Opin. Behav. Sci. 2016 10 142 148 10.1016/j.cobeha.2016.06.006 27822488
    [Google Scholar]
  76. Huang M. Lewine J.D. Lee R.R. Magnetoencephalography for Mild Traumatic Brain Injury and Posttraumatic Stress Disorder. Neuroimaging Clin. N. Am. 2020 30 2 175 192 10.1016/j.nic.2020.02.003 32336405
    [Google Scholar]
  77. Bolzenius J.D. Velez C.S. Lewis J.D. Bigler E.D. Wade B.S.C. Cooper D.B. Kennedy J.E. Reid M.W. Ritter J.L. York G.E. Tate D.F. Diffusion Imaging Findings in US Service Members With Mild Traumatic Brain Injury and Posttraumatic Stress Disorder. J. Head Trauma Rehabil. 2018 33 6 393 402 10.1097/HTR.0000000000000378 29385017
    [Google Scholar]
  78. Boccia M. D’Amico S. Bianchini F. Marano A. Giannini A.M. Piccardi L. Different neural modifications underpin PTSD after different traumatic events: an fMRI meta-analytic study. Brain Imaging Behav. 2016 10 1 226 237 10.1007/s11682‑015‑9387‑3 25913645
    [Google Scholar]
  79. Samuels A.H. Civil forensic psychiatry – Part 2: specific issues. Australas. Psychiatry 2018 26 3 252 255 10.1177/1039856218759236 29457475
    [Google Scholar]
  80. Calvillo M. Irimia A. Neuroimaging and Psychometric Assessment of Mild Cognitive Impairment After Traumatic Brain Injury. Front. Psychol. 2020 11 1423 10.3389/fpsyg.2020.01423 32733322
    [Google Scholar]
  81. Prince C. Bruhns M. Evaluation and Treatment of Mild Traumatic Brain Injury: The Role of Neuropsychology. Brain Sci. 2017 7 8 105 10.3390/brainsci7080105 28817065
    [Google Scholar]
  82. McInnes K. Friesen C.L. MacKenzie D.E. Westwood D.A. Boe S.G. Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review. PLoS One 2017 12 4 e0174847 10.1371/journal.pone.0174847 28399158
    [Google Scholar]
  83. Spinos P. Sakellaropoulos G. Georgiopoulos M. Stavridi K. Apostolopoulou K. Ellul J. Constantoyannis C. Postconcussion syndrome after mild traumatic brain injury in Western Greece. J. Trauma 2010 69 4 789 794 10.1097/TA.0b013e3181edea67 20938266
    [Google Scholar]
  84. Ponsford J.L. Downing M.G. Olver J. Ponsford M. Acher R. Carty M. Spitz G. Longitudinal follow-up of patients with traumatic brain injury: outcome at two, five, and ten years post-injury. J. Neurotrauma 2014 31 1 64 77 10.1089/neu.2013.2997 23889321
    [Google Scholar]
  85. Theadom A. McDonald S. Starkey N. Barker-Collo S. Jones K.M. Ameratunga S. Wilson E. Feigin V.L. Social cognition four years after mild-TBI: An age-matched prospective longitudinal cohort study. Neuropsychology 2019 33 4 560 567 10.1037/neu0000516 30920237
    [Google Scholar]
  86. Jones J.M. Haslam S.A. Jetten J. Williams W.H. Morris R. Saroyan S. That which doesn’t kill us can make us stronger (and more satisfied with life): The contribution of personal and social changes to well-being after acquired brain injury. Psychol. Health 2011 26 3 353 369 10.1080/08870440903440699 20419563
    [Google Scholar]
  87. Pavlovic D. Pekic S. Stojanovic M. Popovic V. Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae. Pituitary 2019 22 3 270 282 10.1007/s11102‑019‑00957‑9 30929221
    [Google Scholar]
  88. Popovic V. Pekic S. Pavlovic D. Maric N. Jasovic-Gasic M. Djurovic B. Medic-Stojanoska M. Zivkovic V. Stojanovic M. Doknic M. Milic N. Djurovic M. Dieguez C. Casanueva F.F. Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distress. J. Endocrinol. Invest. 2004 27 11 1048 1054 10.1007/BF03345308 15754737
    [Google Scholar]
  89. Li M. Sirko S. Traumatic Brain Injury: At the Crossroads of Neuropathology and Common Metabolic Endocrinopathies. J. Clin. Med. 2018 7 3 59 10.3390/jcm7030059 29538298
    [Google Scholar]
  90. Li C. Xu J.J. Hu H.T. Shi C.Y. Yu C.J. Sheng J.Z. Wu Y.T. Huang H.F. Amylin receptor insensitivity impairs hypothalamic POMC neuron differentiation in the male offspring of maternal high-fat diet-fed mice. Mol. Metab. 2021 44 101135 10.1016/j.molmet.2020.101135 33279727
    [Google Scholar]
  91. Mele C. Pingue V. Caputo M. Zavattaro M. Pagano L. Prodam F. Nardone A. Aimaretti G. Marzullo P. Neuroinflammation and Hypothalamo-Pituitary Dysfunction: Focus of Traumatic Brain Injury. Int. J. Mol. Sci. 2021 22 5 2686 10.3390/ijms22052686 33799967
    [Google Scholar]
  92. Arwert L.I. Veltman D.J. Deijen J.B. van Dam P.S. Drent M.L. Effects of growth hormone substitution therapy on cognitive functioning in growth hormone deficient patients: a functional MRI study. Neuroendocrinology 2006 83 1 12 19 10.1159/000093337 16707911
    [Google Scholar]
  93. Falleti M.G. Maruff P. Burman P. Harris A. The effects of growth hormone (GH) deficiency and GH replacement on cognitive performance in adults: A meta-analysis of the current literature. Psychoneuroendocrinology 2006 31 6 681 691 10.1016/j.psyneuen.2006.01.005 16621325
    [Google Scholar]
  94. Nyberg F. Hallberg M. Growth hormone and cognitive function. Nat. Rev. Endocrinol. 2013 9 6 357 365 10.1038/nrendo.2013.78 23629538
    [Google Scholar]
  95. Nieves-Martinez E. Sonntag W.E. Wilson A. Donahue A. Molina D.P. Brunso-Bechtold J. Nicolle M.M. Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation. J. Endocrinol. 2010 204 1 31 36 10.1677/JOE‑09‑0323 19815586
    [Google Scholar]
  96. Chaplin J.E. Kriström B. Jonsson B. Tuvemo T. Albertsson-Wikland K. Growth Hormone Treatment Improves Cognitive Function in Short Children with Growth Hormone Deficiency. Horm. Res. Paediatr. 2015 83 6 390 399 10.1159/000375529 25823753
    [Google Scholar]
  97. Pavlovic D. Pekic S. Stojanovic M. Zivkovic V. Djurovic B. Jovanovic V. Miljic N. Medic-Stojanoska M. Doknic M. Miljic D. Djurovic M. Casanueva F. Popovic V. Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adults. Eur. J. Neurol. 2010 17 5 696 702 10.1111/j.1468‑1331.2009.02910.x 20050894
    [Google Scholar]
  98. Devesa J. Reimunde P. Devesa P. Barberá M. Arce V. Growth hormone (GH) and brain trauma. Horm. Behav. 2013 63 2 331 344 10.1016/j.yhbeh.2012.02.022 22405763
    [Google Scholar]
  99. Lai J. Shi Y.C. Lin S. Chen X.R. Metabolic disorders on cognitive dysfunction after traumatic brain injury. Trends Endocrinol. Metab. 2022 33 7 451 462 10.1016/j.tem.2022.04.003 35534336
    [Google Scholar]
  100. Zhang S. Lachance B.B. Mattson M.P. Jia X. Glucose metabolic crosstalk and regulation in brain function and diseases. Prog. Neurobiol. 2021 204 102089 10.1016/j.pneurobio.2021.102089 34118354
    [Google Scholar]
  101. Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006 444 7121 860 867 10.1038/nature05485 17167474
    [Google Scholar]
  102. McKee A.C. Stein T.D. Huber B.R. Crary J.F. Bieniek K. Dickson D. Alvarez V.E. Cherry J.D. Farrell K. Butler M. Uretsky M. Abdolmohammadi B. Alosco M.L. Tripodis Y. Mez J. Daneshvar D.H. Chronic traumatic encephalopathy (CTE): criteria for neuropathological diagnosis and relationship to repetitive head impacts. Acta Neuropathol. 2023 145 4 371 394 10.1007/s00401‑023‑02540‑w 36759368
    [Google Scholar]
  103. Mez J. Daneshvar D.H. Kiernan P.T. Abdolmohammadi B. Alvarez V.E. Huber B.R. Alosco M.L. Solomon T.M. Nowinski C.J. McHale L. Cormier K.A. Kubilus C.A. Martin B.M. Murphy L. Baugh C.M. Montenigro P.H. Chaisson C.E. Tripodis Y. Kowall N.W. Weuve J. McClean M.D. Cantu R.C. Goldstein L.E. Katz D.I. Stern R.A. Stein T.D. McKee A.C. Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football. JAMA 2017 318 4 360 370 10.1001/jama.2017.8334 28742910
    [Google Scholar]
  104. Mckee A.C. Abdolmohammadi B. Stein T.D. The neuropathology of chronic traumatic encephalopathy. Handb. Clin. Neurol. 2018 158 297 307 10.1016/B978‑0‑444‑63954‑7.00028‑8 30482357
    [Google Scholar]
  105. Pierre K. Dyson K. Dagra A. Williams E. Porche K. Lucke-Wold B. Chronic Traumatic Encephalopathy: Update on Current Clinical Diagnosis and Management. Biomedicines 2021 9 4 415 10.3390/biomedicines9040415 33921385
    [Google Scholar]
  106. Alosco M.L. Mariani M.L. Adler C.H. Balcer L.J. Bernick C. Au R. Banks S.J. Barr W.B. Bouix S. Cantu R.C. Coleman M.J. Dodick D.W. Farrer L.A. Geda Y.E. Katz D.I. Koerte I.K. Kowall N.W. Lin A.P. Marcus D.S. Marek K.L. McClean M.D. McKee A.C. Mez J. Palmisano J.N. Peskind E.R. Tripodis Y. Turner R.W. II Wethe J.V. Cummings J.L. Reiman E.M. Shenton M.E. Stern R.A. Adler C.H. Alosco M.L. Au R. Balcer L. Banks S. Barr W. Bernick C. Bouix S. Cantu R.C. Chen K. Coleman M.J. Cummings J.L. Dodick D.W. Farrer L. Fitzsimmons J. Geda Y. Goldberg J. Helm R. Johnson K.A. Katz D.I. Kirov I. Koerte I.K. Kowall N. Lin A.P. Lui Y. Marcus D.S. Marek K.L. Mariani M. Marmar C. McClean M. McKee A.C. Mez J. Miller J. Palmisano J.N. Pasternak O. Peskind E.R. Protas H. Reiman E. Ritter A. Shenton M.E. Stern R.A. Su Y. Tripodis Y. Turner R.W. Weller J. Wethe J.V. Developing methods to detect and diagnose chronic traumatic encephalopathy during life: rationale, design, and methodology for the DIAGNOSE CTE Research Project. Alzheimers Res. Ther. 2021 13 1 136 10.1186/s13195‑021‑00872‑x 34384490
    [Google Scholar]
  107. Blaylock R. Maroon J. Immunoexcitotoxicity as a central mechanism in chronic traumatic encephalopathy-A unifying hypothesis. Surg. Neurol. Int. 2011 2 1 107 10.4103/2152‑7806.83391 21886880
    [Google Scholar]
  108. Byard R. Tiemensma M. Buckland M.E. Vink R. Chronic traumatic encephalopathy (CTE)—features and forensic considerations. Forensic Sci. Med. Pathol. 2023 19 4 620 624 10.1007/s12024‑023‑00624‑3 37058211
    [Google Scholar]
  109. Randolph C. Chronic traumatic encephalopathy is not a real disease. Arch. Clin. Neuropsychol. 2018 33 5 644 648 10.1093/arclin/acy063 30169776
    [Google Scholar]
  110. Byard R.W. Sports-related deaths. Payne-James J, Byard RW. Forensic and legal medicine: clinical and pathological aspects. Taylor and Francis Publishers 2023 10.1201/9781003138754‑42
    [Google Scholar]
  111. King T. Rosenberg M. Braham R. Ferguson R. Dawson B. Life after the game – Injury profile of past elite Australian Football players. J. Sci. Med. Sport 2013 16 4 302 306 10.1016/j.jsams.2012.09.003 23058879
    [Google Scholar]
  112. Vaaramo K. Puljula J. Tetri S. Head trauma with or without mild brain injury increases the risk of future traumatic death: A controlled prospective 15-year follow-up study. J Neurotrauma. 2015 32 20 1579 1583 10.1089/neu.2014.3757
    [Google Scholar]
  113. Manley G. Gardner A.J. Schneider K.J. Guskiewicz K.M. Bailes J. Cantu R.C. Castellani R.J. Turner M. Jordan B.D. Randolph C. Dvořák J. Hayden K.A. Tator C.H. McCrory P. Iverson G.L. A systematic review of potential long-term effects of sport-related concussion. Br. J. Sports Med. 2017 51 12 969 977 10.1136/bjsports‑2017‑097791 28455362
    [Google Scholar]
  114. Taylor C.A. Bell J.M. Breiding M.J. Xu L. Traumatic Brain Injury–Related Emergency Department Visits, Hospitalizations, and Deaths — United States, 2007 and 2013. MMWR Surveill. Summ. 2017 66 9 1 16 10.15585/mmwr.ss6609a1 28301451
    [Google Scholar]
  115. Byers A.L. Li Y. Barnes D.E. Boscardin W.J. Peltz C.B. Yaffe K. TBI and risk of death in military veterans over 14 years: Injury severity, timing, and cause of death. J. Psychiatr. Res. 2022 156 200 205 10.1016/j.jpsychires.2022.09.035 36257114
    [Google Scholar]
  116. Albrecht J.S. Al Kibria G. Gruber-Baldini A. Magaziner J. Risk of Mortality in Individuals with Hip Fracture and Traumatic Brain Injury. J. Am. Geriatr. Soc. 2019 67 1 124 127 10.1111/jgs.15661 30471090
    [Google Scholar]
  117. Harrison-Felix C.L. Whiteneck G.G. Jha A. DeVivo M.J. Hammond F.M. Hart D.M. Mortality over four decades after traumatic brain injury rehabilitation: a retrospective cohort study. Arch. Phys. Med. Rehabil. 2009 90 9 1506 1513 10.1016/j.apmr.2009.03.015 19735778
    [Google Scholar]
  118. Failla M.D. Conley Y.P. Wagner A.K. Brain-Derived Neurotrophic Factor (BDNF) in Traumatic Brain Injury–Related Mortality. Neurorehabil. Neural Repair 2016 30 1 83 93 10.1177/1545968315586465 25979196
    [Google Scholar]
  119. Munoz M.J. Kumar R.G. Oh B.M. Conley Y.P. Wang Z. Failla M.D. Wagner A.K. Cerebrospinal Fluid Cortisol Mediates Brain-Derived Neurotrophic Factor Relationships to Mortality after Severe TBI: A Prospective Cohort Study. Front. Mol. Neurosci. 2017 10 44 10.3389/fnmol.2017.00044 28337122
    [Google Scholar]
  120. Byers A.L. Li Y. Barnes D.E. Seal K.H. Boscardin W.J. Yaffe K. A national study of TBI and risk of suicide and unintended death by overdose and firearms. Brain Inj. 2020 34 3 328 334 10.1080/02699052.2019.1701708 31822136
    [Google Scholar]
  121. Lu Y.C. Wu M.K. Zhang L. Zhang C.L. Lu Y.Y. Wu C.H. Association between suicide risk and traumatic brain injury in adults: a population based cohort study. Postgrad. Med. J. 2020 96 1142 747 752 10.1136/postgradmedj‑2019‑136860 32015186
    [Google Scholar]
  122. Fazel S. Wolf A. Pillas D. Lichtenstein P. Långström N. Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: a 41-year Swedish population study. JAMA Psychiatry 2014 71 3 326 333 10.1001/jamapsychiatry.2013.3935 24430827
    [Google Scholar]
  123. Günak M.M. Barnes D.E. Yaffe K. Li Y. Byers A.L. Risk of Suicide Attempt in Patients With Recent Diagnosis of Mild Cognitive Impairment or Dementia. JAMA Psychiatry 2021 78 6 659 666 10.1001/jamapsychiatry.2021.0150 33760039
    [Google Scholar]
  124. Greer D.M. Shemie S.D. Lewis A. Torrance S. Varelas P. Goldenberg F.D. Bernat J.L. Souter M. Topcuoglu M.A. Alexandrov A.W. Baldisseri M. Bleck T. Citerio G. Dawson R. Hoppe A. Jacobe S. Manara A. Nakagawa T.A. Pope T.M. Silvester W. Thomson D. Al Rahma H. Badenes R. Baker A.J. Cerny V. Chang C. Chang T.R. Gnedovskaya E. Han M.K. Honeybul S. Jimenez E. Kuroda Y. Liu G. Mallick U.K. Marquevich V. Mejia-Mantilla J. Piradov M. Quayyum S. Shrestha G.S. Su Y. Timmons S.D. Teitelbaum J. Videtta W. Zirpe K. Sung G. Determination of Brain Death/Death by Neurologic Criteria. JAMA 2020 324 11 1078 1097 10.1001/jama.2020.11586 32761206
    [Google Scholar]
  125. Aromatario M. Torsello A. D’Errico S. Bertozzi G. Sessa F. Cipolloni L. Baldari B. Traumatic Epidural and Subdural Hematoma: Epidemiology, Outcome, and Dating. Medicina (Kaunas) 2021 57 2 125 10.3390/medicina57020125 33535407
    [Google Scholar]
  126. Shojania K.G. Burton E.C. The vanishing nonforensic autopsy. N. Engl. J. Med. 2008 358 9 873 875 10.1056/NEJMp0707996 18305264
    [Google Scholar]
  127. Sieswerda-Hoogendoorn T. van Rijn R.R. Current techniques in postmortem imaging with specific attention to paediatric applications. Pediatr. Radiol. 2010 40 2 141 152 10.1007/s00247‑009‑1486‑0 20013258
    [Google Scholar]
  128. Arthurs O.J. Taylor A.M. Sebire N.J. The less invasive perinatal autopsy: current status and future directions. Fetal Matern. Med. Rev. 2013 24 2 45 59 10.1017/S0965539513000065
    [Google Scholar]
  129. Arthurs O.J. Hutchinson J.C. Sebire N.J. Current issues in postmortem imaging of perinatal and forensic childhood deaths. Forensic Sci. Med. Pathol. 2017 13 1 58 66 10.1007/s12024‑016‑9821‑x 28083782
    [Google Scholar]
  130. Ampanozi G. Halbheer D. Ebert L.C. Thali M.J. Held U. Postmortem imaging findings and cause of death determination compared with autopsy: a systematic review of diagnostic test accuracy and meta-analysis. Int. J. Legal Med. 2020 134 1 321 337 10.1007/s00414‑019‑02140‑y 31455980
    [Google Scholar]
  131. Henningsen M.J. Harving M.L. Jacobsen C. Villa C. Fractures of the neuro-cranium: sensitivity and specificity of post-mortem computed tomography compared with autopsy. Int. J. Legal Med. 2022 136 5 1379 1389 10.1007/s00414‑022‑02779‑0 35084533
    [Google Scholar]
  132. Henningsen M.J. Larsen S.T. Jacobsen C. Villa C. Sensitivity and specificity of post-mortem computed tomography in skull fracture detection—a systematic review and meta-analysis. Int. J. Legal Med. 2022 136 5 1363 1377 10.1007/s00414‑022‑02803‑3 35286468
    [Google Scholar]
  133. Calder A.D. Offiah A.C. Foetal radiography for suspected skeletal dysplasia: technique, normal appearances, diagnostic approach. Pediatr. Radiol. 2015 45 4 536 548 10.1007/s00247‑014‑3130‑x 25173408
    [Google Scholar]
  134. Hsieh K.L.C. Zimmerman R.A. Kao H.W. Chen C.Y. Revisiting neuroimaging of abusive head trauma in infants and young children. AJR Am. J. Roentgenol. 2015 204 5 944 952 10.2214/AJR.14.13228 25905928
    [Google Scholar]
  135. Martin A. Paddock M. Johns C.S. Smith J. Raghavan A. Connolly D.J.A. Offiah A.C. Avoiding skull radiographs in infants with suspected inflicted injury who also undergo head CT: “a no-brainer?”. Eur. Radiol. 2020 30 3 1480 1487 10.1007/s00330‑019‑06579‑w 31797078
    [Google Scholar]
  136. Sharp S.R. Patel S.M. Brown R.E. Landes C. Head imaging in suspected non accidental injury in the paediatric population. In the advent of volumetric CT imaging, has the skull X-ray become redundant? Clin. Radiol. 2018 73 5 449 453 10.1016/j.crad.2017.11.027 29502881
    [Google Scholar]
  137. Culotta P.A. Crowe J.E. Tran Q.A. Jones J.Y. Mehollin-Ray A.R. Tran H.B. Donaruma-Kwoh M. Dodge C.T. Camp E.A. Cruz A.T. Performance of computed tomography of the head to evaluate for skull fractures in infants with suspected non-accidental trauma. Pediatr. Radiol. 2017 47 1 74 81 10.1007/s00247‑016‑3707‑7 27744559
    [Google Scholar]
  138. Orman G. Wagner M.W. Seeburg D. Zamora C.A. Oshmyansky A. Tekes A. Poretti A. Jallo G.I. Huisman T.A.G.M. Bosemani T. Pediatric skull fracture diagnosis: should 3D CT reconstructions be added as routine imaging? J. Neurosurg. Pediatr. 2015 16 4 426 431 10.3171/2015.3.PEDS1553 26186360
    [Google Scholar]
  139. Norberti N. Tonelli P. Giaconi C. Nardi C. Focardi M. Nesi G. Miele V. Colagrande S. State of the art in post-mortem computed tomography: a review of current literature. Virchows Arch. 2019 475 2 139 150 10.1007/s00428‑019‑02562‑4 30937612
    [Google Scholar]
  140. Roberts I.S.D. Benamore R.E. Benbow E.W. Lee S.H. Harris J.N. Jackson A. Mallett S. Patankar T. Peebles C. Roobottom C. Traill Z.C. Post-mortem imaging as an alternative to autopsy in the diagnosis of adult deaths: a validation study. Lancet 2012 379 9811 136 142 10.1016/S0140‑6736(11)61483‑9 22112684
    [Google Scholar]
  141. Ruder T.D. Hatch G.M. Ebert L.C. Flach P.M. Ross S. Ampanozi G. Thali M.J. Whole body postmortem magnetic resonance angiography. J. Forensic Sci. 2012 57 3 778 782 10.1111/j.1556‑4029.2011.02037.x 22211886
    [Google Scholar]
  142. Schievano S. Sebire N.J. Robertson N.J. Taylor A.M. Thayyil S. Reconstruction of fetal and infant anatomy using rapid prototyping of post-mortem MR images. Insights Imaging 2010 1 4 281 286 10.1007/s13244‑010‑0028‑5 22347922
    [Google Scholar]
  143. Mondello C. Baldino G. Bottari A. Sapienza D. Perri F. Argo A. Asmundo A. Ventura Spagnolo E. The role of PMCT for the assessment of the cause of death in natural disaster (landslide and flood): a Sicilian experience. Int. J. Legal Med. 2022 136 1 237 244 10.1007/s00414‑021‑02683‑z 34476607
    [Google Scholar]
  144. Grabherr S. Egger C. Vilarino R. Campana L. Jotterand M. Dedouit F. Modern post-mortem imaging: an update on recent developments. Forensic Sci. Res. 2017 2 2 52 64 10.1080/20961790.2017.1330738 30483621
    [Google Scholar]
  145. Gershon A. Little D.A. Ball C.G. Williams A.S. Fatal secondary aortoduodenal fistula diagnosed with postmortem computed tomography angiography. Forensic Sci. Med. Pathol. 2020 16 3 515 518 10.1007/s12024‑020‑00256‑x 32394207
    [Google Scholar]
  146. Zech W.D. Schwendener N. Persson A. Warntjes M.J. Jackowski C. Postmortem MR quantification of the heart for characterization and differentiation of ischaemic myocardial lesions. Eur. Radiol. 2015 25 7 2067 2073 10.1007/s00330‑014‑3582‑2 25591749
    [Google Scholar]
  147. Makino Y. Arai N. Hoshioka Y. Yoshida M. Kojima M. Horikoshi T. Mukai H. Iwase H. Traumatic axonal injury revealed by postmortem magnetic resonance imaging: A case report. Leg. Med. (Tokyo) 2019 36 9 16 10.1016/j.legalmed.2018.09.019 30312836
    [Google Scholar]
  148. Makino Y. Kojima M. Yoshida M. Motomura A. Inokuchi G. Chiba F. Torimitsu S. Hoshioka Y. Yamaguchi R. Saito N. Urabe S. Tsuneya S. Horikoshi T. Yajima D. Iwase H. Postmortem CT and MRI findings of massive fat embolism. Int. J. Legal Med. 2020 134 2 669 678 10.1007/s00414‑019‑02128‑8 31375910
    [Google Scholar]
  149. Chen Y.J. [Research development and application of virtopsy]. Fa Yi Xue Za Zhi 2014 30 5 360 366 [Chinese.]. 25735075
    [Google Scholar]
  150. Blokker B.M. Weustink A.C. Wagensveld I.M. von der Thüsen J.H. Pezzato A. Dammers R. Bakker J. Renken N.S. den Bakker M.A. van Kemenade F.J. Krestin G.P. Hunink M.G.M. Oosterhuis J.W. Conventional Autopsy versus Minimally Invasive Autopsy with Postmortem MRI, CT, and CT-guided Biopsy: Comparison of Diagnostic Performance. Radiology 2018 289 3 658 667 10.1148/radiol.2018180924 30251930
    [Google Scholar]
  151. Jia Y.Q. Jin G.D. Tian M.H. Effect of corpse cryopreservation on forensic pathological identification. Fa Yi Xue Za Zhi. 2019 35 1 74 77 10.12116/j.issn.1004‑5619.2019.01.014
    [Google Scholar]
  152. Najem D. Rennie K. Ribecco-Lutkiewicz M. Traumatic brain injury: Classification, models, and markers. Biochem Cell Biol. 2018 96 4 391 406 10.1139/bcb‑2016‑0160
    [Google Scholar]
  153. Thomas I. Dickens A.M. Posti J.P. Czeiter E. Duberg D. Sinioja T. Kråkström M. Retel Helmrich I.R.A. Wang K.K.W. Maas A.I.R. Steyerberg E.W. Menon D.K. Tenovuo O. Hyötyläinen T. Büki A. Orešič M. Åkerlund C. Amrein K. Andelic N. Andreassen L. Anke A. Antoni A. Audibert G. Azouvi P. Azzolini M.L. Bartels R. Barzó P. Beauvais R. Beer R. Bellander B-M. Belli A. Benali H. Berardino M. Beretta L. Blaabjerg M. Bragge P. Brazinova A. Brinck V. Brooker J. Brorsson C. Bullinger M. Cabeleira M. Caccioppola A. Calappi E. Calvi M.R. Cameron P. Lozano G.C. Carbonara M. Cavallo S. Chevallard G. Chieregato A. Citerio G. Clusmann H. Coburn M. Coles J. Cooper J.D. Correia M. Čović A. Curry N. Czeiter E. Czosnyka M. Dahyot-Fizelier C. Dark P. Dawes H. De Keyser V. Degos V. Corte F.D. den Boogert H. Depreitere B. Đilvesi Đ. Dixit A. Donoghue E. Dreier J. Dulière G-L. Ercole A. Esser P. Ezer E. Fabricius M. Feigin V.L. Foks K. Frisvold S. Furmanov A. Gagliardo P. Galanaud D. Gantner D. Gao G. George P. Ghuysen A. Giga L. Glocker B. Golubovic J. Gomez P.A. Gratz J. Gravesteijn B. Grossi F. Gruen R.L. Gupta D. Haagsma J.A. Haitsma I. Helbok R. Helseth E. Horton L. Huijben J. Hutchinson P.J. Jacobs B. Jankowski S. Jarrett M. Jiang J. Johnson F. Jones K. Karan M. Kolias A.G. Kompanje E. Kondziella D. Kornaropoulos E. Koskinen L-O. Kovács N. Kowark A. Lagares A. Lanyon L. Laureys S. Lecky F. Ledoux D. Lefering R. Legrand V. Lejeune A. Levi L. Lightfoot R. Lingsma H. Maas A.I.R. Castaño-León A.M. Maegele M. Majdan M. Manara A. Manley G. Martino C. Maréchal H. Mattern J. McMahon C. Melegh B. Menovsky T. Mikolic A. Misset B. Muraleedharan V. Murray L. Negru A. Nelson D. Newcombe V. Nieboer D. Nyirádi J. Olubukola O. Ortolano F. Palotie A. Parizel P.M. Payen J-F. Perera N. Perlbarg V. Persona P. Peul W. Piippo-Karjalainen A. Pirinen M. Ples H. Polinder S. Pomposo I. Posti J.P. Puybasset L. Radoi A. Ragauskas A. Raj R. Rambadagalla M. Rhodes J. Richardson S. Richter S. Ripatti S. Rocka S. Roe C. Roise O. Rosand J. Rosenfeld J.V. Rosenlund C. Rosenthal G. Rossaint R. Rossi S. Rueckert D. Rusnák M. Sahuquillo J. Sakowitz O. Sanchez-Porras R. Sandor J. Schäfer N. Schmidt S. Schoechl H. Schoonman G. Schou R.F. Schwendenwein E. Sewalt C. Skandsen T. Smielewski P. Sorinola A. Stamatakis E. Stanworth S. Stevens R. Stewart W. Stocchetti N. Sundström N. Takala R. Tamás V. Tamosuitis T. Taylor M.S. Te Ao B. Theadom A. Thomas M. Tibboel D. Timmers M. Tolias C. Trapani T. Tudora C.M. Unterberg A. Vajkoczy P. Vallance S. Valeinis E. Vámos Z. van der Jagt M. Van der Steen G. van der Naalt J. van Dijck J.T.J.M. van Essen T.A. Van Hecke W. van Heugten C. Van Praag D. Vyvere T.V. van Wijk R.P.J. Vargiolu A. Vega E. Velt K. Verheyden J. Vespa P.M. Vik A. Vilcinis R. Volovici V. von Steinbüchel N. Voormolen D. Vulekovic P. Wiegers E. Williams G. Wilson L. Winzeck S. Wolf S. Yang Z. Ylén P. Younsi A. Zeiler F.A. Zelinkova V. Ziverte A. Zoerle T. Serum metabolome associated with severity of acute traumatic brain injury. Nat. Commun. 2022 13 1 2545 10.1038/s41467‑022‑30227‑5 35538079
    [Google Scholar]
  154. Undén J. Ingebrigtsen T. Romner B. Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update. BMC Med. 2013 11 1 50 10.1186/1741‑7015‑11‑50 23432764
    [Google Scholar]
  155. Oris C. Kahouadji S. Durif J. Bouvier D. Sapin V. S100B, Actor and Biomarker of Mild Traumatic Brain Injury. Int. J. Mol. Sci. 2023 24 7 6602 10.3390/ijms24076602 37047574
    [Google Scholar]
  156. Belsey S.L. Flanagan R.J. Postmortem biochemistry: Current applications. J. Forensic Leg. Med. 2016 41 49 57 10.1016/j.jflm.2016.04.011 27131037
    [Google Scholar]
  157. Breitling B. Brunkhorst R. Verhoff M. Foerch C. Post-mortem serum concentrations of GFAP correlate with agony time but do not indicate a primary cerebral cause of death. PLoS One 2018 13 10 e0205323 10.1371/journal.pone.0205323 30304049
    [Google Scholar]
  158. Olczak M. Kwiatkowska M. Niderla-Bielińska J. Chutorański D. Tarka S. Wierzba-Bobrowicz T. Brain-originated peptides as possible biochemical markers of traumatic brain injury in cerebrospinal fluid post-mortem examination. Folia Neuropathol. 2018 56 2 97 103 10.5114/fn.2018.76613 30509029
    [Google Scholar]
  159. Ondruschka B. Sieber M. Kirsten H. Franke H. Dreßler J. Measurement of Cerebral Biomarkers Proving Traumatic Brain Injuries in Post-Mortem Body Fluids. J. Neurotrauma 2018 35 17 2044 2055 10.1089/neu.2017.5441 29732941
    [Google Scholar]
  160. Ondruschka B. Woydt L. Bernhard M. Franke H. Kirsten H. Löffler S. Pohlers D. Hammer N. Dreßler J. Post-mortem in situ stability of serum markers of cerebral damage and acute phase response. Int. J. Legal Med. 2019 133 3 871 881 10.1007/s00414‑018‑1925‑2 30167776
    [Google Scholar]
  161. Trautz F. Franke H. Bohnert S. Hammer N. Müller W. Stassart R. Tse R. Zwirner J. Dreßler J. Ondruschka B. Survival-time dependent increase in neuronal IL-6 and astroglial GFAP expression in fatally injured human brain tissue. Sci. Rep. 2019 9 1 11771 10.1038/s41598‑019‑48145‑w 31417126
    [Google Scholar]
  162. Sieber M. Dreßler J. Franke H. Pohlers D. Ondruschka B. Post-mortem biochemistry of NSE and S100B: A supplemental tool for detecting a lethal traumatic brain injury? J. Forensic Leg. Med. 2018 55 65 73 10.1016/j.jflm.2018.02.016 29471249
    [Google Scholar]
  163. Olczak M. Poniatowski Ł.A. Niderla-Bielińska J. Kwiatkowska M. Chutorański D. Tarka S. Wierzba-Bobrowicz T. Concentration of microtubule associated protein tau (MAPT) in urine and saliva as a potential biomarker of traumatic brain injury in relationship with blood–brain barrier disruption in postmortem examination. Forensic Sci. Int. 2019 301 28 36 10.1016/j.forsciint.2019.05.010 31128406
    [Google Scholar]
  164. Kousi C. Lampri E. Voulgaris S. Vougiouklakis T. Galani V. Mitselou A. Expression of orexin-A (hypocretin-A) in the hypothalamus after traumatic brain injury: A postmortem evaluation. Forensic Sci. Int. 2021 327 110961 10.1016/j.forsciint.2021.110961 34454377
    [Google Scholar]
  165. Olczak M. Poniatowski Ł. Kwiatkowska M. Samojłowicz D. Tarka S. Wierzba-Bobrowicz T. Immunolocalization of dynein, dynactin, and kinesin in the cerebral tissue as a possible supplemental diagnostic tool for traumatic brain injury in postmortem examination. Folia Neuropathol. 2019 57 1 51 62 10.5114/fn.2019.83831 31038188
    [Google Scholar]
  166. Zwirner J. Bohnert S. Franke H. Garland J. Hammer N. Möbius D. Tse R. Ondruschka B. Assessing Protein Biomarkers to Detect Lethal Acute Traumatic Brain Injuries in Cerebrospinal Fluid. Biomolecules 2021 11 11 1577 10.3390/biom11111577 34827575
    [Google Scholar]
  167. Zwirner J. Anders S. Bohnert S. Burkhardt R. Da Broi U. Hammer N. Pohlers D. Tse R. Ondruschka B. Screening for Fatal Traumatic Brain Injuries in Cerebrospinal Fluid Using Blood-Validated CK and CK–MB Immunoassays. Biomolecules 2021 11 7 1061 10.3390/biom11071061 34356685
    [Google Scholar]
  168. Gao T.L. Yuan X.T. Yang D. Dai H.L. Wang W.J. Peng X. Shao H.J. Jin Z.F. Fu Z.J. Expression of HMGB1 and RAGE in rat and human brains after traumatic brain injury. J. Trauma 2012 72 3 643 649 10.1097/TA.0b013e31823c54a6 22491548
    [Google Scholar]
  169. Kobek M. Jankowski Z. Szala J. Gąszczyk-Ożarowski Z. Pałasz A. Skowronek R. Time-related morphometric studies on CD34 protein expression in the cerebral blood vessels after fatal brain contusions. Folia Neuropathol. 2018 56 3 187 195 10.5114/fn.2018.78699 30509040
    [Google Scholar]
  170. Neri M. Frati A. Turillazzi E. Cantatore S. Cipolloni L. Di Paolo M. Frati P. La Russa R. Maiese A. Scopetti M. Santurro A. Sessa F. Zamparese R. Fineschi V. Immunohistochemical Evaluation of Aquaporin-4 and its Correlation with CD68, IBA-1, HIF-1α, GFAP, and CD15 Expressions in Fatal Traumatic Brain Injury. Int. J. Mol. Sci. 2018 19 11 3544 10.3390/ijms19113544 30423808
    [Google Scholar]
  171. Oerter S. Förster C. Bohnert M. Validation of sodium/glucose cotransporter proteins in human brain as a potential marker for temporal narrowing of the trauma formation. Int. J. Legal Med. 2019 133 4 1107 1114 10.1007/s00414‑018‑1893‑6 30073510
    [Google Scholar]
  172. Zwirner J. Kulakofsky R. Fitzek A. Schröder A.S. Bohnert S. Franke H. Renné T. Tse R. Ondruschka B. Forensic biomarkers of lethal traumatic brain injury. Int. J. Legal Med. 2022 136 3 871 886 10.1007/s00414‑022‑02785‑2 35226180
    [Google Scholar]
  173. Pinchi E. Frati A. Cipolloni L. Aromatario M. Gatto V. La Russa R. Pesce A. Santurro A. Fraschetti F. Frati P. Fineschi V. Clinical-pathological study on β-APP, IL-1β, GFAP, NFL, Spectrin II, 8OHdG, TUNEL, miR-21, miR-16, miR-92 expressions to verify DAI-diagnosis, grade and prognosis. Sci. Rep. 2018 8 1 2387 10.1038/s41598‑018‑20699‑1 29402984
    [Google Scholar]
  174. MacKenzie J.M. Axonal Injury in Stroke. Am. J. Forensic Med. Pathol. 2015 36 3 172 175 10.1097/PAF.0000000000000166 26266889
    [Google Scholar]
  175. Woydt L. Bernhard M. Kirsten H. Burkhardt R. Hammer N. Gries A. Dreßler J. Ondruschka B. Intra-individual alterations of serum markers routinely used in forensic pathology depending on increasing post-mortem interval. Sci. Rep. 2018 8 1 12811 10.1038/s41598‑018‑31252‑5 30143737
    [Google Scholar]
  176. Shang Y. Wang Y. Guo Y. Ren L. Zhang X. Wang S. Zhang C. Cai J. Analysis of the risk of traumatic brain injury and evaluation neurogranin and myelin basic protein as potential biomarkers of traumatic brain injury in postmortem examination. Forensic Sci. Med. Pathol. 2022 18 3 288 298 10.1007/s12024‑022‑00459‑4 35201602
    [Google Scholar]
  177. Bohnert S. Wirth C. Schmitz W. Trella S. Monoranu C.M. Ondruschka B. Bohnert M. Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury. Int. J. Legal Med. 2021 135 4 1525 1535 10.1007/s00414‑021‑02606‑y 33895854
    [Google Scholar]
  178. Boutté AM. Hook V. Thangavelu B. Penetrating traumatic brain injury triggers dysregulation of cathepsin B protein levels independent of cysteine protease activity in brain and cerebral spinal fluid. J Neurotrauma. 2020 37 13 1574 1586 10.1089/neu.2019.6537
    [Google Scholar]
  179. Hayashi T. Ago K. Nakamae T. Higo E. Ogata M. Two different immunostaining patterns of beta-amyloid precursor protein (APP) may distinguish traumatic from nontraumatic axonal injury. Int. J. Legal Med. 2015 129 5 1085 1090 10.1007/s00414‑015‑1245‑8 26249371
    [Google Scholar]
  180. Hicks C. Dhiman A. Barrymore C. Traumatic Brain Injury Biomarkers, Simulations and Kinetics. Bioengineering. 2022 9 11 612 10.3390/bioengineering9110612
    [Google Scholar]
  181. Ackermann M. Verleden S.E. Kuehnel M. Haverich A. Welte T. Laenger F. Vanstapel A. Werlein C. Stark H. Tzankov A. Li W.W. Li V.W. Mentzer S.J. Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N. Engl. J. Med. 2020 383 2 120 128 10.1056/NEJMoa2015432 32437596
    [Google Scholar]
  182. Marshall A.G. Neikirk K. Stephens D.C. Vang L. Vue Z. Beasley H.K. Crabtree A. Scudese E. Lopez E.G. Shao B. Krystofiak E. Rutledge S. Davis J. Murray S.A. Damo S.M. Katti P. Hinton A. Jr Serial Block Face‐Scanning Electron Microscopy as a Burgeoning Technology. Adv. Biol. 2023 7 8 2300139 10.1002/adbi.202300139 37246236
    [Google Scholar]
  183. Goossens E. Deblock L. Caboor L. Eynden D.V. Josipovic I. Isaacura P.R. Maksimova E. Van Impe M. Bonnin A. Segers P. Cornillie P. Boone M.N. Van Driessche I. De Spiegelaere W. De Roo J. Sips P. De Buysser K. From Corrosion Casting to Virtual Dissection: Contrast‐Enhanced Vascular Imaging using Hafnium Oxide Nanocrystals. Small Methods 2024 e2301499 2301499 10.1002/smtd.202301499 38200600
    [Google Scholar]
  184. Sultan I. Ramste M. Peletier P. Hemanthakumar K.A. Ramanujam D. Tirronen A. von Wright Y. Antila S. Saharinen P. Eklund L. Mervaala E. Ylä-Herttuala S. Engelhardt S. Kivelä R. Alitalo K. Contribution of VEGF-B-Induced Endocardial Endothelial Cell Lineage in Physiological Versus Pathological Cardiac Hypertrophy. Circ. Res. 2024 134 11 1465 1482 10.1161/CIRCRESAHA.123.324136 38655691
    [Google Scholar]
  185. Albano G.D. Stassi C. Argo A. Zerbo S. An Overview on the Use of miRNAs as Possible Forensic Biomarkers for the Diagnosis of Traumatic Brain Injury. Int. J. Mol. Sci. 2023 24 7 6503 10.3390/ijms24076503 37047473
    [Google Scholar]
  186. Glynn C.L. Potential applications of microRNA profiling to forensic investigations. RNA 2020 26 1 1 9 10.1261/rna.072173.119 31658993
    [Google Scholar]
  187. Rocchi A. Chiti E. Maiese A. Turillazzi E. Spinetti I. MicroRNAs: An Update of Applications in Forensic Science. Diagnostics (Basel) 2020 11 1 32 10.3390/diagnostics11010032 33375374
    [Google Scholar]
  188. Sessa F. Maglietta F. Bertozzi G. Salerno M. Di Mizio G. Messina G. Montana A. Ricci P. Pomara C. Human Brain Injury and miRNAs: An Experimental Study. Int. J. Mol. Sci. 2019 20 7 1546 10.3390/ijms20071546 30934805
    [Google Scholar]
  189. Pennisi G. Torrisi M. Cocimano G. Esposito M. Salerno M. Sessa F. Vitality markers in forensic investigations: a literature review. Forensic Sci. Med. Pathol. 2022 19 1 103 116 10.1007/s12024‑022‑00551‑9 36331706
    [Google Scholar]
  190. Polito F. Famà F. Oteri R. Raffa G. Vita G. Conti A. Daniele S. Macaione V. Passalacqua M. Cardali S. Di Giorgio R.M. Gioffrè M. Angileri F.F. Germanò A. Aguennouz M.H. Circulating miRNAs expression as potential biomarkers of mild traumatic brain injury. Mol. Biol. Rep. 2020 47 4 2941 2949 10.1007/s11033‑020‑05386‑7 32219772
    [Google Scholar]
  191. O’Connell G.C. Smothers C.G. Winkelman C. Bioinformatic analysis of brain-specific miRNAs for identification of candidate traumatic brain injury blood biomarkers. Brain Inj. 2020 34 7 965 974 10.1080/02699052.2020.1764102 32497449
    [Google Scholar]
  192. Yang Y. Wang Y. Li P. Bai F. Liu C. Huang X. Serum exosomes miR-206 and miR-549a-3p as potential biomarkers of traumatic brain injury. Sci. Rep. 2024 14 1 10082 10.1038/s41598‑024‑60827‑8 38698242
    [Google Scholar]
  193. Bonin S. D’Errico S. Medeot C. Moreschi C. Ciglieri S.S. Peruch M. Concato M. Azzalini E. Previderè C. Fattorini P. Evaluation of a Set of miRNAs in 26 Cases of Fatal Traumatic Brain Injuries. Int. J. Mol. Sci. 2023 24 13 10836 10.3390/ijms241310836 37446013
    [Google Scholar]
  194. Olsen C.M. Corrigan J.D. Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder? Biol. Psychiatry 2022 91 5 421 437 10.1016/j.biopsych.2021.07.013 34561027
    [Google Scholar]
  195. Weil Z.M. Corrigan J.D. Karelina K. Alcohol Use Disorder and Traumatic Brain Injury. Alcohol Res. 2018 39 2 171 180 31198656
    [Google Scholar]
  196. Bjork J.M. Grant S.J. Does traumatic brain injury increase risk for substance abuse? J. Neurotrauma 2009 26 7 1077 1082 10.1089/neu.2008.0849 19203230
    [Google Scholar]
  197. Eyer M.M. Renier C.M. Woehrle T.A. Vogel L.E. Conway P.G. McCarty C.A. Alcohol Use at the Time of Traumatic Brain Injury: Screening and Brief Intervention in a Community Hospital. J. Trauma Nurs. 2017 24 2 116 124 10.1097/JTN.0000000000000275 28272186
    [Google Scholar]
  198. Mathias J.L. Osborn A.J. Impact of day-of-injury alcohol consumption on outcomes after traumatic brain injury: A meta-analysis. Neuropsychol. Rehabil. 2018 28 6 997 1018 10.1080/09602011.2016.1224190 27585824
    [Google Scholar]
  199. Johnston J.J.E. McGovern S.J. Alcohol related falls: an interesting pattern of injuries. Emerg. Med. J. 2004 21 2 185 188 10.1136/emj.2003.006130 14988344
    [Google Scholar]
  200. Chikritzhs T. Livingston M. Alcohol and the Risk of Injury. Nutrients 2021 13 8 2777 10.3390/nu13082777 34444939
    [Google Scholar]
  201. Posti J.P. Sankinen M. Sipilä J.O.T. Ruuskanen J.O. Rinne J. Rautava P. Kytö V. Fatal traumatic brain injuries during 13 years of successive alcohol tax increases in Finland – a nationwide population-based registry study. Sci. Rep. 2019 9 1 5419 10.1038/s41598‑019‑41913‑8 30931989
    [Google Scholar]
  202. Ţolescu R.Ş. Zorilă M.V. Şerbănescu M.S. Kamal C. Zorilă G.L. Dumitru I. Florou C. Mogoantă L. Văduva I.A. Stanca L. Zăvoi R.E. Severe traumatic brain injury (TBI) – a seven-year comparative study in a Department of Forensic Medicine. Rom. J. Morphol. Embryol. 2020 61 1 95 103 10.47162/RJME.61.1.10 32747899
    [Google Scholar]
  203. Wang H. Yu X. Xu G. Xu G. Gao G. Xu X. Alcoholism and traumatic subarachnoid hemorrhage: an experimental study on vascular morphology and biomechanics. J. Trauma 2011 70 1 E6 E12 10.1097/TA.0b013e3181cda3b9 21217473
    [Google Scholar]
  204. Lai X. Yu X. Qian H. Wei L. Lv J. Xu X. Chronic alcoholism-mediated impairment in the medulla oblongata: a mechanism of alcohol-related mortality in traumatic brain injury? Cell Biochem. Biophys. 2013 67 3 1049 1057 10.1007/s12013‑013‑9603‑y 23546937
    [Google Scholar]
  205. Parker S.L. Saxena M. Gowardman J. Lipman J. Myburgh J. Roberts J.A. Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. J. Crit. Care 2018 47 15 20 10.1016/j.jcrc.2018.05.016 29883885
    [Google Scholar]
  206. Empey P.E. McNamara P.J. Young B. Rosbolt M.B. Hatton J. Cyclosporin A disposition following acute traumatic brain injury. J. Neurotrauma 2006 23 1 109 116 10.1089/neu.2006.23.109 16430377
    [Google Scholar]
  207. Empey P.E. Velez de Mendizabal N. Bell M.J. Bies R.R. Anderson K.B. Kochanek P.M. Adelson P.D. Poloyac S.M. Therapeutic hypothermia decreases phenytoin elimination in children with traumatic brain injury. Crit. Care Med. 2013 41 10 2379 2387 10.1097/CCM.0b013e318292316c 23896831
    [Google Scholar]
  208. Chisholm K.M. Harruff R.C. Elderly deaths due to ground-level falls. Am. J. Forensic Med. Pathol. 2010 31 4 350 354 10.1097/PAF.0b013e3181f69c87 20938326
    [Google Scholar]
  209. Lavoie A. Ratte S. Clas D. Demers J. Moore L. Martin M. Bergeron E. Preinjury warfarin use among elderly patients with closed head injuries in a trauma center. J. Trauma 2004 56 4 802 807 10.1097/01.TA.0000066183.02177.AF 15187746
    [Google Scholar]
  210. Pieracci F.M. Eachempati S.R. Shou J. Hydo L.J. Barie P.S. Use of long-term anticoagulation is associated with traumatic intracranial hemorrhage and subsequent mortality in elderly patients hospitalized after falls: analysis of the New York State Administrative Database. J. Trauma 2007 63 3 519 524 10.1097/TA.0b013e31812e519b 18073595
    [Google Scholar]
  211. Launiainen T. Sajantila A. Rasanen I. Vuori E. Ojanperä I. Adverse interaction of warfarin and paracetamol: evidence from a post-mortem study. Eur. J. Clin. Pharmacol. 2010 66 1 97 103 10.1007/s00228‑009‑0727‑3 19779704
    [Google Scholar]
  212. Hollowell J. Meier C.R. Haefeli W.E. Gasse C. Drug interactions and risk of acute bleeding leading to hospitalisation or death in patients with chronic atrial fibrillation treated with warfarin. Thromb. Haemost. 2005 94 9 537 543 10.1160/TH05‑03‑0166 16268469
    [Google Scholar]
  213. Wittkowsky A.K. Boccuzzi S.J. Wogen J. Wygant G. Patel P. Hauch O. Frequency of concurrent use of warfarin with potentially interacting drugs. Pharmacotherapy 2004 24 12 1668 1674 10.1592/phco.24.17.1668.52338 15585436
    [Google Scholar]
  214. Feldstein A.C. Smith D.H. Perrin N. Yang X. Simon S.R. Krall M. Sittig D.F. Ditmer D. Platt R. Soumerai S.B. Reducing warfarin medication interactions: an interrupted time series evaluation. Arch. Intern. Med. 2006 166 9 1009 1015 10.1001/archinte.166.9.1009 16682575
    [Google Scholar]
  215. Snaith A. Pugh L. Simpson C.R. McLay J.S. The potential for interaction between warfarin and coprescribed medication: a retrospective study in primary care. Am. J. Cardiovasc. Drugs 2008 8 3 207 212 10.2165/00129784‑200808030‑00007 18533741
    [Google Scholar]
  216. Di Nunno N. Esposito M. Argo A. Salerno M. Sessa F. Pharmacogenetics and Forensic Toxicology: A New Step towards a Multidisciplinary Approach. Toxics 2021 9 11 292 10.3390/toxics9110292 34822683
    [Google Scholar]
  217. Adams S.M. Conley Y.P. Wagner A.K. Jha R.M. Clark R.S.B. Poloyac S.M. Kochanek P.M. Empey P.E. The pharmacogenomics of severe traumatic brain injury. Pharmacogenomics 2017 18 15 1413 1425 10.2217/pgs‑2017‑0073 28975867
    [Google Scholar]
  218. Aly S.M. Hennart B. Gaulier J.M. Allorge D. Effect of CYP2D6, 2C19, and 3A4 Phenoconversion in Drug-Related Deaths. Toxics 2024 12 4 260 10.3390/toxics12040260 38668482
    [Google Scholar]
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Advances and Challenges in Traumatic Brain Injury from a Forensic Perspective
Bentham Science Publishers ; https://doi.org/10.2174/011570159X352125241031030110
/content/journals/cn/10.2174/011570159X352125241031030110
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  • Article Type:     Review Article
Keywords: Traumatic brain injury ; cause of death ; pathogenesis ; Forensic

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