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- Volume 5, Issue 3, 2005
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents - Volume 5, Issue 3, 2005

Volume 5, Issue 3, 2005
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Concept of Comprehensive Treatment for Osteoarthritis (OA)
More LessThe cause of osteoarthritis (OA) - the most prevalent joint disease - remains unknown and no cure has been identified. The OA patient seeks help because of symptoms (primarily pain) and impaired function. However, the underlying mechanisms resulting in pain or structural damage that contribute to impairment of joint function are not completely understood. Currently available drug treatments are palliative at best. Alth Read More
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Development of COX-2 Selective Inhibitors - Therapeutic Perspectives
Authors: S. R. Casturi, P. Hegde and R. RamanujamAspirin and conventional nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely prescribed for the treatment of musculoskeletal disorders with a major dose limiting gastrointestinal toxicity. However the discovery of inducible second isozyme of cyclooxygenase-2 (COX-2) opened up a new era in therapeutics. The selective COX-2 inhibitors have emerged as a class of compounds f Read More
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Oxidative Stress and the Use of Antioxidants for the Treatment of Rheumatoid Arthritis
Authors: Charles Kunsch, James A. Sikorski and Cynthia L. SundellOxidant stress as a result of increased production of reactive oxygen species (ROS) or a reduction in the body's endogenous antioxidant defense system is a hallmark of chronic inflammatory diseases including rheumatoid arthritis (RA). A primary source of ROS in RA is leukocytes (i.e. activated macrophages, neutrophils, mast cells and lymphocytes) that are recruited to, and that accumulate within, the synovium. ROS Read More
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Disease Modification in Rheumatoid Arthritis and Osteoarthritis-Current and Emerging Targets and Therapeutics
Authors: Maya Vally and Sivaram PillarisettiThe population effected by rheumatoid arthritis (RA) and osteoarthritis (OA) is increasing worldwide. There is also a dramatic progress in the understanding of the etiology and pathophysiology of these diseases and the use of biological disease modifying anti-rheumatic drugs (DMARD) for the treatment of RA. High costs of biological DMARDs and the lack of oral drugs are the biggest limitations to RA therapy. In addition, the Read More
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Recombinant Interleukin-12 for Immunotherapy: A Double-Sided Sword
Authors: A. Hombach, C. Heuser, A. Stallmach and H. AbkenThe innate and adaptive immune responses are closely linked and mutually reinforcing. The type of adaptive immune response is strongly influenced by the cytokines produced by innate immune cells. Interleukin-12 (IL-12) plays a key role in linking innate immunity to an adaptive T helper-1 (Th1) response against pathogens and tumor cells, thereby counteracting an imbalanced Th2 immune response. These propert Read More
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GH-Inhibitory Activity of Novel Somatostatin Agonists: Potential Applications in Acromegaly
By P. DasguptaAcromegaly is a relatively rare debilitating disease caused by hypersecretion of growth hormone (GH). Despite a multimodality approach involving surgery, radiation, dopamine agonists and somatostatin agonists the management of acromegaly in some patients has remained a challenge. Although, octreotide and lanreotide are the mainstay for medical therapy in acromegaly, their relatively short biological half-life, pharm Read More
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The Endocrine Function of Adipose Tissue
Authors: Tiziana Ronti, Graziana Lupattelli and Elmo MannarinoThe traditional view of the adipocyte as a passive receptacle for storage and combustion of triacylglycerol is undergoing rapid change. It is now recognized that a variety of adipocyte and adipose stromal cell derived bioactive peptides, collectively termed “adipokines”, act both locally and distally through autocrine, paracrine and endocrine effects. Alteration of adipose tissue mass in obesity increases the production of mos Read More
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