Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*

Wieslaw M. Kazmierski; Jennifer P. Peckham; Maosheng Duan; Terry P. Kenakin; Stephen Jenkinson; Kristjan S. Gudmundsson; Stephen C. Piscitelli; Paul L. Feldman

doi:10.2174/1568012053506981

ISSN: 1568-0126
E-ISSN: 1875-600X

Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*
Authors: Wieslaw M. Kazmierski¹, Jennifer P. Peckham², Maosheng Duan³, Terry P. Kenakin⁴, Stephen Jenkinson⁵, Kristjan S. Gudmundsson⁶, Stephen C. Piscitelli⁷ and Paul L. Feldman⁸
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¹ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ² GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ³ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ⁴ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ⁵ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ⁶ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ⁷ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA. ⁸ GlaxoSmithKline, 5 Moore Drive, Research Triangle Park, NC 27709, USA.
Source: Current Medicinal Chemistry - Anti-Infective Agents, Volume 4, Issue 2, Apr 2005, p. 133 - 152
DOI: https://doi.org/10.2174/1568012053506981
- Available online: 01 Apr 2005

Abstract

This review addresses key medicinal chemistry issues relevant in the discovery and development of CCR5 and CXCR4 antagonists as anti-HIV drugs. Recent progress in the discovery and development of such antagonists, SAR and clinical status are reviewed.

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2005-04-01

2025-06-24

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Article Type: Review Article

Keyword(s): aids; allosteric modulator; ccr5 receptor; chemokine; chemotherapy; probe; transcriptase inhibitors

Recent Progress in the Discovery of New CCR5 and CXCR4 Chemokine Receptor Antagonists as Inhibitors of HIV-1 Entry. Part 2*

Abstract

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