s Polyglandular Autoimmune Syndromes

Polyglandular Autoimmune Syndromes (PAS) form different clusters of autoimmune disorders characterized by the coexistence of at least two glandular autoimmune mediated diseases [1]. They are generally classified into three types: a very rare juvenile type 1(PAS I) and a relatively common adult type with (PAS II) or without adrenal failure (PAS III) [2, 3]. PAS I, also known as autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), is associated with candidiasis, hypoparathyroidism, and adrenal failure. PAS II is associated with adrenal failure, thyroid diseases and type 1 diabetes mellitus. In this review we will shed light on both types of PAS including their clinical picture and ways of management.