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Volume 20, Issue 3
  • ISSN: 1574-8863
  • E-ISSN: 2212-3911

Abstract

Introduction/Aim

The study examines how chronic resveratrol administration affects behavioral and neurochemical changes caused by Lorazepam (LZP), a classical anti-anxiety medicine associated with neurodegenerative and neurological problems.

Methods

Forty male rats were placed into four groups: a control group receiving 1% Tween 80, the LZP group receiving 2 mg/kg/day, the Resveratrol group receiving 50 mg/kg/day, and the LZP plus resveratrol group receiving the same doses of LZP and Resveratrol. Oral therapy was given daily for 6 weeks. The animals were euthanized after open field and Y maze behavioral tests. In specific brain regions, neurochemical analyses were performed on GABA, glutamic acid, monoamines (norepinephrine, dopamine, and serotonin) and their metabolites, DNA fragmentation (8-hydroxy-2–deoxyguanosine or 8-HdG), brain-derived neurotrophic factor (BDNF), and Ca-ATPase.

Results

Resveratrol therapy improved GABA, glutamic acid, monoamines, and their metabolites in the cerebral cortex, hippocampus, and striatum. Additionally, it reduced DNA fragmentation (8-HdG) and counteracted LZP-induced Ca-ATPase downregulation at a significant level ( 0.05). Resveratrol also reversed LZP-induced behavioral changes in the Y maze and open field tests.

Conclusion

Resveratrol has anxiolytic-like actions like benzodiazepines and neuroprotective capabilities against LZP-induced adverse effects.

© 2025 Bentham Science Publishers
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2024-10-09
2025-07-03

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/content/journals/cds/10.2174/0115748863312358240919103439
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Resveratrol Neuroprotective Action Against Cognitive Impairments Induced by Lorazepam in Male Rats
Curr Drug Saf 20, 341 (2025); https://doi.org/10.2174/0115748863312358240919103439
/content/journals/cds/10.2174/0115748863312358240919103439
/content/journals/cds/10.2174/0115748863312358240919103439
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  • Article Type:     Research Article
Keyword(s): cognitive deficits; Lorazepam; neurobehavior; neuroprotection; neurotransmitters; resveratrol

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