Skip to content
2000
Volume 15, Issue 2
  • ISSN: 1573-3998
  • E-ISSN: 1875-6417

Abstract

Introduction: Challenges facing the treatment of type 2 diabetes necessitate the search for agents which act via alternative pathways to provide better therapeutic outcomes. Recently, an increasing body of evidence implicates the activation of oestrogen receptors (ERα and ERβ) in the development and treatment of underlying conditions in type 2 diabetes. This article summarizes available evidence for the involvement of oestrogen receptors in insulin secretion, insulin resistance as well as glucose uptake and highlights the potential of ERβ as a therapeutic target. Background: Recent studies indicate an association between the activation of each of the isoforms of ER and recent findings indicate that ERβ shows promise as a potential target for antidiabetic drugs. In vitro and in vivo studies in receptor knockout mice indicate beneficial actions of selective agonists of ERβ receptor and underscore its therapeutic potential. Conclusion: Studies are needed to further elucidate the exact mechanism underlying the role of ERβ activation as a therapeutic approach in the management of type 2 diabetes.

Loading

Article metrics loading...

/content/journals/cdr/10.2174/1573399814666180119141836
2019-04-01
2025-06-11
Loading full text...

Full text loading...

/content/journals/cdr/10.2174/1573399814666180119141836
Loading

  • Article Type:
    Review Article
Keyword(s): ERα; ERβ; GLUT4; GPER; insulin resistance; Oestrogen receptor; type 2 diabetes
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test