Importance of Propellants and Excipients in Pharmaceutical Topical Aerosol

Skin is the most suitable and recommendable organ of the human body for topical administration and the main route for topical drug delivery system. Drug delivery system is the methodology used to ensure the entry of drugs into the body, reaching their target for pharmacological action. Patients tend to prefer the painless route for drug administration. So, pharmaceutical aerosols came to existence to meet patient compliance. Many variations in excipients with respect to compatibility to drugs, stability and economy are being used to improve the aerosol system of drug delivery. The present review deals with the excipients and constituents used in a pharmaceutical aerosol system as per target delivery. Summary: The review deals with the excipients and constituents used in a pharmaceutical aerosol system as per target delivery. Conclusion: Presently, aerosol drug delivery system has become beneficial as far as faster pharmacological action and economy are concerned. Other than the active pharmaceutical ingredient (API), the pharmacological action of the aerosol system is also dependent on the excipients used as they help the API to penetrate through the skin as fast as possible.