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image of Fluconazole-loaded Hyaluronic Acid-modified Transfersomal Hydrogels Containing D-panthenol for Ocular Delivery in Fungal Keratitis Management

Abstract

Background

Fungal keratitis (mycotic keratitis) is an eye infection in which the cornea is infected by fungi and such fungal keratitis management can be effectively possible by ocular administration of antifungal drugs.

Objective

The main objectives of the present research were to develop and evaluate fluconazole-loaded transfersomal hydrogels for ocular delivery in the effective management of fungal keratitis.

Methods

A 23 factorial design-based approach was used for statistical optimization, where (A) the ratio of lipid to edge activators, (B) the amount of hyaluronic acid (% HA), and (C) the ratio of edge activators (sodium deoxycholate to Span 80) were taken as three factors. The average vesicle diameter (Z, nm) of transfersomes was taken as a response. Further, fluconazole-loaded transfersomes (FTO) were incorporated into 1% Carbopol 940-based hydrogel (OF1) and 2% HMPC K4M-based hydrogel (OF2) containing D-panthenol (5% w/w).

Results

The optimal variable setting for the optimized formulations of FTO was (A) = 9.15, (B) = 0.30%, and (C) = 3.00. FTO exhibited 66.39 nm Z, 0.247 polydispersity index, – 33.10 mV zeta potential, and 65.38 ± 1.77% DEE, and desirable elasticity. TEM image of FTO demonstrated a unilamellar vesicular structure. The ocular permeation of fluconazole from transfersomal hydrogels was sustained over 24 h. All the transfersomal hydrogels showed good bioadhesion and excellent antifungal activity with respect to the zone of inhibition against than . HET-CAM study results demonstrated that both the hydrogels were non-irritant and safe for ocular. Short-term physical stability study suggested the stability of the developed formulation.

Conclusion

The current research demonstrated a new way to enhance the ocular penetration of fluconazole transfersomal hydrogel formulations for ocular delivery in the effective management of fungal keratitis.

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2024-10-18
2024-11-23

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/content/journals/cdd/10.2174/0115672018342369241018050810
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Fluconazole-loaded Hyaluronic Acid-modified Transfersomal Hydrogels Containing D-panthenol for Ocular Delivery in Fungal Keratitis Management
Bentham Science Publishers ; https://doi.org/10.2174/0115672018342369241018050810
/content/journals/cdd/10.2174/0115672018342369241018050810
/content/journals/cdd/10.2174/0115672018342369241018050810
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  • Article Type:     Research Article
Keywords: Drug delivery ; hydrogels ; ophthalmology ; antifungal ; eyes

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