Genome Wide Analysis of Protein Phosphatase 2C (PP2C) Genes in Glycine max and Sorghum bicolor

Background: Protein kinases and phosphatases are involved in the regulation of numerous biological processes by catalyzing proteins phosphorylation and de-phosphorylation status respectively. Protein Phosphatase 2C requires divalent ion for its activity and is categorized under family protein serine/threonine phosphatases i.e. they act on serine or threonine residues. Objective: The present study is focused on genome-wide analysis of Protein phosphatase 2C genes in Glycine max (dicot) and Sorghum bicolor (monocot) using various Bioinformatics tools. Method: Tools like NCBI and SMART were used to identify the presence of PP2C genes and their catalytic domains were identified. The duplication and splicing patterns of the PP2C genes were studied with the help of Webscipio tool. Result: On the basis of conserved domains, PP2C genes were further classified into various families using multiple sequence alignment method. The presence of paralogous genes was analyzed representing a strong evolutionary relationship among these families (bootstrap value >90%). Presence of some more catalytic domains was observed along with the PP2Cc in the plants.