Skip to content
2000
Volume 8, Issue 1
  • ISSN: 1574-8936
  • E-ISSN: 2212-392X

Abstract

Protein-protein interactions play important roles in many biological progresses. Previous studies about proteinprotein interactions were mainly based on sequence analysis. As more 3D structural information can be obtained from protein-protein complexes, structural analysis becomes feasible and useful. In this study, we used structural alignment to predict protein-binding sites and analyzed interface properties using 3D alpha shape. We have developed a method for protein-protein interaction prediction. The result indicates good performance of our method in discriminating proteinbinding structures from non-protein-binding structures. In the experiment, our method shows best Matthews correlation coefficient of 0.204.

Loading

Article metrics loading...

/content/journals/cbio/10.2174/157489313804871597
2013-02-01
2025-05-03
Loading full text...

Full text loading...

/content/journals/cbio/10.2174/157489313804871597
Loading
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test