oa Editorial [Hot Topic: Bioinformatics on Proteins and Complexes (Guest Editor: M. Michael Gromiha)]

Proteins and their interactions play vital roles in living organisms. Elucidating the mechanism of protein folding as well as the recognition of proteins with other molecules (proteins, nucleic acids and carbohydrates and ligands) are intriguing and challenging problems in computational and molecular biology. The problem of protein folding, stability and interactions has been viewed through several perspectives using experimental and computational approaches. Further, Bioinformatics has been successfully applied to enhance our understanding on protein folding, stability and their interactions. The special issue on “Bioinformatics on proteins and complexes” is aimed at providing a recent update on the computational analysis of proteins based on their folding, stability and interactions. It addressed various issues such as sequence-structure similarity, structure prediction, folding rates and stability of proteins. Further, it covered proteinprotein/ protein-RNA interactions, structure based drug design and proteomics analysis. The special issue is broadly classified into three parts; the first part is focused on the aspects of protein folding and stability with six articles, second part is devoted to protein interactions, which has four papers and the last part is dealing with database searching and preprocessing in mass spectrometry based proteomics....