Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics

Jie Li; Cheng-Wei Tom Chang

doi:10.2174/187152106777697844

ISSN: 1871-5214
E-ISSN: 1875-6018

Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics
Authors: Jie Li¹ and Cheng-Wei Tom Chang²
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¹ Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA. ² Department of Chemistry and Biochemistry, Utah State University, 0300 Old Main Hill, Logan, Utah 84322-0300, USA.
Source: Anti-Infective Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Infective Agents), Volume 5, Issue 3, Jul 2006, p. 255 - 271
DOI: https://doi.org/10.2174/187152106777697844
- Available online: 01 Jul 2006

Abstract

Aminoglycosides represent an important resource against infectious diseases. However, the prevalence of aminoglycoside resistant bacteria has limited their clinical efficacy and prompted the renewed interest in the study of resistant mechanisms as well as the development of novel aminoglycoside antibiotics. This review will focus on the latest development in the design and synthesis of novel aminoglycoside derivatives.

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2006-07-01

2025-05-21

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Article Type: Research Article

Keyword(s): Conformational constrained neomycin; glycosylation; Kanamycin; methicillin resistant S. aureus (MRSA); O-5 Glycosylated Neomycin; RNA targets; Tobramycin Derivatives

Recent Developments in the Synthesis of Novel Aminoglycoside Antibiotics

Abstract

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