Genetic Polymorphism in Allergic Rhinitis

Allergic rhinitis (AR) is considered to be multifactorial inflammatory diseases involving complex interactions between genetic and environmental influences. Inflammatory reactions in AR are regulated by many cytokines. The impact of genetic factors on the pathogenesis of AR is currently an area of intense investigation. Various loci and candidate genes have been suggested to underlie allergy. Many or all are still controversial. No significant evidence for linkage to AR has been shown so far, although significant evidence for linkage to various allergic diseases. The aim of this review was to investigate whether the genetic polymorphisms were associated with AR in the literature.