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2000
Volume 5, Issue 3
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Interleukin-26 (IL-26) belongs to the family of cellular cytokines which share sequence homology with IL-10, however, without functional conservation. The il-26 gene is situated on the human chromosome 12q15 in close neighbourhood to the genes for the related T-cellular cytokines interferon-γ (IFN-γ) and IL-22. il-26 was discovered due to its overexpression in T cells after growth transformation with herpesvirus saimiri. IL-26 is produced by activated T cells, forms homodimers, and acts on epithelial target cells such as colon carcinoma cells or keratinocytes. Presumably due to its positive net charge, IL-26 adheres to glycosaminoglycans on cell surfaces. Stimulation with IL-26 results in the phosphorylation and activation of the transcription factors STAT1 and STAT3 and in the induction of CD54 surface expression and secretion of cytokines such as IL-8 and IL-10. These effects are mediated by an IL-26-specific receptor complex consisting of IL-20R1 and IL-10R2. Thus, IL-26 appears to be a rather proinflammatory and cell-surface associated cytokine linking local T-cell activation with epithelial functions.

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/content/journals/aiaamc/10.2174/187152306778017674
2006-08-01
2025-05-28
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/content/journals/aiaamc/10.2174/187152306778017674
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  • Article Type:
    Research Article
Keyword(s): AK155; colon carcinoma; herpesvirus saimiri; ICAM-1; IL-26; Interleukin-26; STAT; T cell
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