Full text loading...
- ISSN: 1871-5230
- E-ISSN: 1875-614X
-
Synthetic Inhibitors of Group IVA and Group VIA Phospholipase A2
- Source: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents), Volume 5, Issue 2, May 2006, p. 189 - 203
-
- 01 May 2006
- Previous Article
- Table of Contents
- Next Article
Abstract
PLA2 is an important signaling enzyme that generates multiple downstream effectors, such as arachidonic acid and PAF, which are key mediators of inflammation as well as other pathophysiological conditions. Inhibition of PLA2 is potentially an effective therapy for several inflammatory diseases. In this review, we discuss the various classes of synthetic inhibitors of Group IVA and Group VIA phospholipase A2.
© Bentham Science Publishers