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2000
Volume 20, Issue 1
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Background: For the first time, the investigation of six anti-inflammatory drugs and six antihistaminic drugs for inhibitory activities against alpha-amylase has been evaluated using a new inhibition detection method in order to find new treatments for some diseases caused by α-amylase. Objective: The first part of this work was devoted to the evaluation of the inhibition activity of these drugs on salivary α-amylase in vitro. Then to study the nature of interactions and structure-activity relationship, using the Autodockvina program for molecular docking. Materials and Methods: The evaluation of the inhibitory activity of our drugs is achieved using a new method that has proved its sensitivity, quickness, and effectiveness. Results: The results of this study show that betamethasone and loratadine are potent α-amylase inhibitors with IC50 values 0.7mg/ml and 1.03 mg/ml, respectively compared to acarbose with IC50=5.6 μg/ml. Conclusion: The results showed that the loratadine and the betamethasone have a strong potential to inhibit the alpha-amylase.

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/content/journals/aiaamc/10.2174/1871523019666200102111048
2021-03-01
2025-06-27
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