Skip to content
2000
Volume 16, Issue 3
  • ISSN: 1871-5230
  • E-ISSN: 1875-614X

Abstract

Background: Various mediators and anti-inflammatory drugs were used since from a long time but it is still a challenge for the medicinal chemists to treat or reduce the symptoms of inflammatory diseases. Most of the clinically used anti-inflammatory drugs such as NSAIDs, Coxibs and GCs are allied with considerable toxicity. Objective: The search of novel anti-inflammatory agent is not an ending process. Although the drug treatment has been improved steadily but yet, it is still there is a need to develop more potent therapeutic agents. Method: Reported literature survey has been studied to summarize the nitrogen containing moieties which were utilized as potential therapeutic agents. Results: A variety of N-heterocyclic analogs are known to exhibit a wide range of interesting biological activities like antioxidant, anti-inflammatory, anticonvulsant, analgesic, antimicrobial, anticancer, antiprotozoal, antioxidant, antiparasitic, antiplatelet, cardioprotective, anthelmintic, antidiabetic, antitubercular, trypanocidal and anti-HIV. However, numerous approaches were used to overcome the toxicity level such as co-administration with suitable agent/substance which provides protection against toxicity as well to synthesise new potent and safe anti-inflammatory drug. Conclusion: The present review summarizes the synthetic methodology and therapeutic potential of some N-heterocyclic analogs as potent anti-inflammatory agents.

Loading

Article metrics loading...

/content/journals/aiaamc/10.2174/1871523017666180126150901
2017-12-01
2025-07-04
Loading full text...

Full text loading...

/content/journals/aiaamc/10.2174/1871523017666180126150901
Loading

  • Article Type:
    Review Article
Keyword(s): Imidazole; inflammation; NSAIDs; pyrazoles; pyrimidine; quinazoline
This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error
Please enter a valid_number test